Jordan Squair (@j_squair) profile picture

Jordan Squair

@j_squair

SNSF Ambizione Fellow. EPFL. UBC MD/PhD.

 Lausanne, Switzerland
Joined January 2011
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  • Following285
  • Followers196
Comparative whole-brain and single-cell analyses are identifying neurons orchestrating neurological functions. Learn more in a new #SciencePerspective: scim.ag/3WMwLDR
Image from Science Magazine (@ScienceMagazine)
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The neuroscience of brain cancers: Neuron cell.com/neuron/fulltext/S08…
The neuroscience of brain cancers

The neuroscience of brain cancers

Neuron-cancer interactions are central to brain cancer pathophysiology. The perspective by Monje summarizes the current understanding of the neuroscience of brain cancers, poses key open questions,...

cell.com
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Jordan Squair retweeted
nature (@Nature) profile picture
nature
@Nature19 Jun 2024
Nature research paper: Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica go.nature.com/3VOLvSQ
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Discover our latest study, published in @ScienceMagazine , which reveals a groundbreaking approach to regenerating axons through complete spinal cord injury, reversing paralysis. Read the full article here: science.org/doi/full/10.1126…
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Thrilled to share our Tabulae Paralytica: snRNA-seq, multiome, 2D- and 3D spatial transcriptomic atlases of spinal cord injury 📷 biorxiv.org/content/10.1101/…… @j_squair @gcourtine @skinniderlab
Image from NeuroRestore.swiss (@_NeuroRestore)
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THE NEURONS THAT RESTORE WALKING AFTER PARALYSIS. Read our new publication in @Nature today! The mechanisms explaining the recovery of walking by 9 individuals with spinal cord injury in response to electrical spinal cord stimulation. nature.com/articles/s41586-0…
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Jordan Squair retweeted
NEJM (@NEJM) profile picture
NEJM
@NEJM7 Apr 2022
Patient with multiple-system atrophy regained the ability to stand and walk without syncope using an implanted stimulator coupled with accelerometers that detected changes in body position. nej.md/3u7NLa3
Image from NEJM (@NEJM)
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MSA leads to syncopes when standing. Our electronic implant prevents these drops in blood pressure, restoring walking. Read our latest article released today in @NEJM ! @CHUVLausanne @EPFL_en nejm.org/doi/full/10.1056/NE…
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy | NEJM

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy | NEJM

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods....

nejm.org
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Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in spinal cord injury patients with complete paralysis nature.com/articles/s41591-0…
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Our new @NatureMedicine publication is released! A purposed-buit stimulation technology designed by @onwdempowered that rapidly restores trunk and leg motor functions after complete paralysis. nature.com/articles/s41591-0…
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🚨 Differential expression is an important part of understanding cell type specific responses to disease. Check out our recent work in @NatureComms that exposes a proliferation of false discoveries and shows how to avoid them: nature.com/articles/s41467-0…
Confronting false discoveries in single-cell differential expression

Confronting false discoveries in single-cell differential expression

Nature Communications - Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show...

nature.com
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Want to identify the cell types in your single-cell data that are most responsive to your perturbation? Check out our step-by-step walkthrough of Augur (nature.com/articles/s41587-0…) just published @NatureProtocols (nature.com/articles/s41596-0…).
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Jordan Squair retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint12 Mar 2021
Confronting false discoveries in single-cell differential expression biorxiv.org/cgi/content/shor… #bioRxiv
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News & Views: The inability to maintain blood pressure is a debilitating consequence of spinal cord injury. This problem has now been circumvented by artificially recreating a reflex essential for blood-pressure stability, according to a Nature paper. go.nature.com/2YhhMDs
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Check out our #biorxiv_neursci #biorxiv preprint comparing the proteomic response to spinal cord injury in patients and pigs @ICORD_SCI
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint28 Jan 2021
Proteomic portraits reveal evolutionarily conserved and divergent responses to spinal cord injury biorxiv.org/cgi/content/shor… #bioRxiv
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A Nature paper shows a spinal stimulation treatment that restores blood pressure maintenance after spinal cord injury in animal models. Preliminary investigations in human patients indicate that the human spinal cord also responds to this treatment. go.nature.com/2NHNNTe

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

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Congrats to @EPFL_en @gcourtine, @DrAaronPhillips & their incredible teams for developing a treatment that allows patients with a #spinalcord injury to regain control of their blood pressure, using targeted electrical spinal-cord stimulation. @NatureNeuro campusbiotech.ch/en/node/933
Image from Campus Biotech (@CampusBiotech)
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Replying to @NaturePortfolio
@nature paper from Team Lead @DrAaronPhillips and @j_squair @gcourtine They developed a next-gen hemo-therapy for #spinalcordinjury. We look forward to the subsequent clinical trials with @onwdempowered and @DARPA nature.com/articles/s41586-0…
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Today, we announced data in @nature showing targeted spinal cord stimulation stabilizes blood pressure in people with spinal cord injury. We look forward to continuing research to demonstrate how our technology can improve care for people living with SCI. bwnews.pr/3iPNa5o
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CSO Grégoire Courtine was awarded the Institution of Engineering’s A F Harvey Engineering Research Prize. We’re grateful for the recognition & contribution that allows us to continue researching treatments for people living with spinal cord injuries. bit.ly/3axhSOP
Image from ONWARD Medical (@onwdempowered)
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