Julie Laffy (@jlaffy) header
Julie Laffy (@jlaffy) profile picture

Julie Laffy

@jlaffy

Eric and Wendy Schmidt Fellow @BroadInstitute || Systems Bio PhD '23 @WeizmannInstitute

github.com/jlaffy
Joined September 2015
  • Tweets61
  • Following414
  • Followers142
1Media
Photo by Julie Laffy (@jlaffy)
📢 Excited to announce the #ICML2025 workshop on *Scaling Up Intervention Models (SIM)*! Let’s bring together state-of-the-art ideas on modeling novel interventions and distribution shifts. :) 🙌🏻 Submissions are welcome! Link: sites.google.com/view/sim-ic…
Image from Jiaqi Zhang (@JiaqiZhangVic)
24
2
113
17,620
Excited to share our latest preprint, introducing the hierarchical cross-entropy (HCE) loss — a simple change that consistently improves performance in atlas-scale cell type annotation models. doi.org/10.1101/2025.04.23.6…
Image from Sebastiano Cultrera di Montesano (@sebacultrera)
1
8
3
13
4,282
Julie Laffy retweeted
Paul Brennan (@Lyonpaul) profile picture
Paul Brennan@Lyonpaul15 Dec 2023
Brilliant piece in @NewYorker by @DrSidMukherjee on the causes of cancer and role of cancer promotion, including interviews with @CharlesSwanton and Allan Balmain, and much much more. There's something for everyone, including fans of Sherlock Holmes. newyorker.com/magazine/2023/…
All the Carcinogens We Cannot See

All the Carcinogens We Cannot See

We routinely test for chemicals that cause mutations. What about the dark matter of carcinogens—substances that don’t create cancer cells but rouse them from their slumber?

newyorker.com
1
21
4
75
10,515
Julie Laffy retweeted
Yann LeCun (@ylecun) profile picture
Yann LeCun
@ylecun25 Jan 2023
A reasonable policy by Nature about the use of LLMs for paper writing. - LLMs are tools with accountability and cannot be listed as coauthor. - LLMs usage should be acknowledged because the transparency of methods is necessary in science. nature.com/articles/d41586-0…
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use

Nature - As researchers dive into the brave new world of advanced AI chatbots, publishers need to acknowledge their legitimate uses and lay down clear guidelines to avoid abuse.

nature.com
26
89
12
446
110,199
No country has a more easily recognizable population density as Egypt. The Nile is everything to the nation. Source: buff.ly/3WqWOxJ HT: @researchremora
Image from Simon Kuestenmacher (@simongerman600)
44
463
48
3,792
474,326
Julie Laffy retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol25 Jan 2023
Cool cover @Nature Based on discovery that stop codons don't stop but code (in some protozoan organisms) nature.com/articles/s41586-0…
Image from Eric Topol (@EricTopol)
12
633
110
2,487
397,453
Julie Laffy retweeted
Kevin Cannon (@multikev) profile picture
Kevin Cannon@multikev21 Jan 2023
The future of email with ChatGPT.
Image from Kevin Cannon (@multikev)
127
2,946
502
18,409
2,564,734
Julie Laffy retweeted
Anna Obenauf (@obenaufa) profile picture
Anna Obenauf@obenaufa21 Jun 2022
Very nice resource by the @TiroshLab that provides access to >70 cancer scRNAseq datasets - collected in one place, annotated and analyzed. weizmann.ac.il/sites/3CA/ #EESMetastasis @embl @EMBO
Image from Anna Obenauf (@obenaufa)
4
64
3
214
Now online in @CD_AACR: Developmental Deconvolution for Classification of #Cancer Origin @garg_lab @kochinstitute @broadinstitute @MGHPathology #cancerofunknownprimary aacrjournals.org/cancerdisco…
Image from Elizabeth McKenna (@ElizSMcKenna)
12
2
51
Julie Laffy retweeted
Sam Altman (@sama) profile picture
Sam Altman
@sama6 Apr 2022
Have an idea for DALL·E? Reply with a caption. I'll generate 20 or so!
1,891
1,286
1,127
6,774
Julie Laffy retweeted
Tirosh Lab (@TiroshLab) profile picture
Tirosh Lab@TiroshLab21 Nov 2021
Excited to share our preprint by @AvishaySpitzer, @GritschSimon, @MarioSuva, Dan Cahill and @KeithLigon5, demonstrating that mutant-IDH inhibitors (mIDHi) act as differentiation therapy in Oligodendroglioma (OG). medrxiv.org/content/10.1101/…
Mutant IDH Inhibitors Induce Lineage Differentiation in IDH-mutant Oligodendroglioma

Mutant IDH Inhibitors Induce Lineage Differentiation in IDH-mutant Oligodendroglioma

Recent data showed promising signs of objective tumor responses in subsets of patients with low grade glioma treated with inhibitors of mutant IDH (IDHi) ([1][1]). However, the molecular and cellular...

medrxiv.org
2
5
1
34
Julie Laffy retweeted
Shai Bel (@Mucus_Man) profile picture
Shai Bel@Mucus_Man20 Nov 2021
Being a #newPI
Image from Shai Bel (@Mucus_Man)
18
162
33
2,347
Julie Laffy retweeted
Mario Suva (@MarioSuva) profile picture
Mario Suva@MarioSuva19 Nov 2021
The 5th edition of the WHO classification of CNS tumors is online today! Great timing with @NeuroOnc 2021 meeting! tumourclassification.iarc.wh…
Image from Mario Suva (@MarioSuva)
1
91
5
288
Julie Laffy retweeted
Tirosh Lab (@TiroshLab) profile picture
Tirosh Lab@TiroshLab13 May 2021
We're excited to share our newly published pan-cancer analysis of EMT by Mike Tyler. By integrating single-cell and bulk RNA-seq data, we could characterise EMT and its clinical significance across cancer types, controlling for the presence of stroma. 1/6 nature.com/articles/s41467-0…
Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression...

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression...

Nature Communications - Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA...

nature.com
4
40
5
129
Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity - by my @meyersonlab lab mate Trevor nature.com/articles/s43018-0…
6
1
42
Congratulations @alissacg and Gabi Kinker!! Awesome paper :)
Alissa Greenwald (@alissacg) profile pictureAlissa Greenwald@alissacg1 Nov 2020
A thread below on our new pan-cancer scRNA-Seq paper on recurrent programs of heterogeneity across cell lines @NatureGenet co-led with the wonderful Gabi Kinker! With lots of gratitude to Itay and to our co-authors and collaborators including @RotemTal6 and @ZhannieOR.
2
Excited to share our review of brain development, focusing on what is known about the emergence of cortical areas. Great work by @crcadwell @mohammedmostajo , Aparna Bhaduri and Matt Keefe cell.com/neuron/fulltext/S08…
Image from Nowakowski_Lab (@LabNowakowski)
8
60
3
180
Julie Laffy retweeted
DrORourke (@DrORourke2) profile picture
DrORourke@DrORourke26 Sep 2020
Big paper with particular importance to #Glioblastoma Congrats to @roelverhaak @mischellab and @HowardYChang
Cancer Discovery (@CD_AACR) profile pictureCancer Discovery@CD_AACR4 Sep 2020
#ResearchWatch: Oncogene amplification on extrachromosomal DNA is common in cancer and is associated with prognosis. @mischellab @roelverhaak @HowardYChang @UCSanDiego @jacksonlab #Genetics bit.ly/32Uv6zK
Image from Cancer Discovery (@CD_AACR)
1
4
11
An excellent and highly recommended improvement on algorithms for estimating RNA velocity of single cells! As usual from @fabian_theis lab with user-friendly software package, clear docs and tutorials.
Nature Biotechnology (@NatureBiotech) profile pictureNature Biotechnology
@NatureBiotech3 Aug 2020
Generalizing RNA velocity to transient cell states through dynamical modeling go.nature.com/30m2ak0
Image from Nature Biotechnology (@NatureBiotech)
90
1
258
What drives the initiation and growth of a lethal early childhood brain cancer with no genomic mutations at all? Paradigm shifting work: Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma cell.com/cell/fulltext/S0092…

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Hypoxia reprograms the cellular metabolome and epigenome to promote growth of the most lethal ependymomas.

cell.com
1
29
1
109
Load more