Jorge Roel (@jroeltou) profile picture

Jorge Roel

@jroeltou
Joined February 2019
  • Tweets403
  • Following88
  • Followers127
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Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)Photo by Jorge Roel (@jroeltou)
Jorge Roel retweeted
Aaron Ring (@aaronmring) profile picture
Aaron Ring
@aaronmringFeb 11
Muting everyone on my timeline hyping technical reports. They are ADVERTISEMENTS and not even good ones. Non-falsifiable. Worthless. "Hey look what I say I can do! But don't try to validate anything we are claiming. PS pay us $10m+ to use our tech. Plebs not welcome."
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Jorge Roel retweeted
Jorge Roel (@jroeltou) profile picture
Jorge Roel@jroeltou21 Feb 2025
Replying to @dxbarradas
The results might hold true. Problem is that all these wrong-called "white papers" (and unfortunately many peer-reviewed ones too) lack thoughtful analyses and are therefore scientifically irrelevant... Science is increasingly losing its essence... So disappointing
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Am I the only one who finds these results extremely puzzling? When introducing novel proteins the performance somewhat drops (as expected) but when also introducing novel ligands the performance skyrockets 😂
Protenix (@ai4s_protenix) profile pictureProtenix
@ai4s_protenix20 Feb 2025
We just releasd our new docking tool: ProteniX-Dock ! Welcome everyone to try out~ GNU GPL3 so allows commercial use, and has a nice Python interface and CLI😁 Let's dive into it! 🧵
Image from Protenix (@ai4s_protenix)
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🎯 Job Alert: #AI Scientist! 💡Are you a talented AI Scientist? Come work with us in #Barcelona to build the future models at the interface of AI and #enzyme discovery & engineering! We offer a salary of €45k-60k, but we are open to discuss with more experienced candidates! 👇🏽
Zymvol Biomodeling (@zymvol) profile pictureZymvol Biomodeling@zymvol27 Sep 2024
We're #HIRING an AI Scientist. Check out the full details at zymvol.com/careers/ #AI #ML #Biotech
Image from Zymvol Biomodeling (@zymvol)
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DeepMind patents symmetric protein design. freepatentsonline.com/y2024/…
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Happy to see it published onlinelibrary.wiley.com/doi/…
The structural landscape of the immunoglobulin fold by large‐scale de novo design

The structural landscape of the immunoglobulin fold by large‐scale de novo design

De novo designing immunoglobulin-like frameworks that allow for functional loop diversification shows great potential for crafting antibody-like scaffolds with fully customizable structures and...

onlinelibrary.wiley.com
Jorge Roel (@jroeltou) profile pictureJorge Roel@jroeltou5 Oct 2023
🚨 We've generated a comprehensive dataset of ~50K high-quality de novo Ig domains, from an in silico screening of ~4M scaffolds, structurally divergent from naturally occurring ones. We uncovered conformational features shaping the structure and function of the Ig fold 🚨
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💣 lavanguardia.com/economia/20…
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Ir a mercadona y volver a casa con salfumán, queso havarti y 4 bitcoins...
Image from Jorge Roel (@jroeltou)
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“The structural landscape of the immunoglobulin fold by large-scale de novo design” 🧶🧬 Explores Ig design using combinations of RFDiffusion, ProteinMPNN, AF2, inpainting, they observe some structural biases for some methods biorxiv.org/content/10.1101/… github.com/JorgeRoel/betasan…
Image from Diego del Alamo (@DdelAlamo)
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🚨 We've generated a comprehensive dataset of ~50K high-quality de novo Ig domains, from an in silico screening of ~4M scaffolds, structurally divergent from naturally occurring ones. We uncovered conformational features shaping the structure and function of the Ig fold 🚨
bioRxiv Bioinfo (@biorxiv_bioinfo) profile picturebioRxiv Bioinfo@biorxiv_bioinfo4 Oct 2023
The structural landscape of the immunoglobulin fold by large-scale de novo design biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
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🚨 We've designed, bifunctionalized, characterized and diversified single-chain immunoglobulin dimers. We believe these scaffolds open exciting avenues for a new generation of bispecifics @IBMB_CSIC @EMBO @EMBOFellows nature.com/articles/s41467-0…
Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops

Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops

Nature Communications - Here the authors describe principles for de novo designing single-chain immunoglobulin dimers with interfaces diverging from those seen in antibodies, showing enhanced...

nature.com
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Replying to @beyzakaynarca_ @zymvol @br_jimenez @jroeltou
Is that a protein? Is that a star? No, it is the Turkish flag! 🇹🇷 🤍 You left us with an unforgettable memory with the Turkish flag-shaped protein-protein docking challenges you prepared. Coming together with you is such a great opportunity! ✨🌸@zymvol @br_jimenez @jroeltou
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Super nice tutorial from @zymvol @br_jimenez @jroeltou on how to use LightDock to predict protein-protein interactions! | Teşekkürler! 💜 Moltes gràcies
Image from Beyza Kaynarca (@beyzakaynarca_)
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An enjoyable read frontiersin.org/articles/10.…
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"Rational Prediction of PROTAC-compatible Protein-Protein Interfaces by Molecular Docking" has been updated A nice demonstration of a situation when ordinarily-SOTA docking methods are unsuitable biorxiv.org/content/10.1101/…
Image from Diego del Alamo (@DdelAlamo)
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If publishing in traditional peer reviewed journals is devil, why keep doing it? Either accept the game rules or play for a *REAL* change #StopHypocrisy
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SALVAJE IS OUT PARA K VAYAN A PASARELEAR LAS SIRENAS o youtu.be/tPHpFWRGWO0
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Only a week left to apply for our #EMBOIntegModelling23 course, which is organized in beautiful Izmir 🏖️ If you want to learn top-notch modelling and simulation techniques from world-renowned experts, just go ahead and apply for our course through meetings.embo.org/event/23-b… (pls RT)
Image from Ezgi Karaca (@Ezgi_Karaca_)
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Go Utrecht Go 🍻🍻🍻
🌊 🌱Jim van Belzen 🪱🦋🦉 (@JimvanBelzen) profile picture🌊 🌱Jim van Belzen 🪱🦋🦉@JimvanBelzen22 May 2023
Now at @pintofscienceNL Utrecht which is starting soon
Image from 🌊 🌱Jim van Belzen 🪱🦋🦉 (@JimvanBelzen)
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