Jonathan Sadlowe (@jsadlowe) header
Jonathan Sadlowe (@jsadlowe) profile picture

Building @imageassist + SonoNeuro + IRIS Biopsy & Investing @gossamercap Previously @googlecloud @spacioushq (acq WeWork) MS MolBio/MBA

Joined January 2008
Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)Photo by Jonathan Sadlowe (@jsadlowe)
The best NYC mayor endorses Cuomo and I couldn’t agree more
Four months ago I endorsed @AndrewCuomo because I thought his management experience and government know-how made him the best choice for New Yorkers. I still do. And today, with early voting underway, I wanted to reiterate my support for Andrew Cuomo. Being Mayor of New York City is the second toughest job in America, and the next mayor will face immense challenges. Andrew Cuomo has the experience and toughness to stand up for New Yorkers and get things done. I hope you will join me in supporting him.
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I'm humbled and excited to be selected for the @Stacks Treasury Committee! 🫡 I truly believe Stacks has the potential to transform the Bitcoin economy, and I can't wait brining my experience, skills, and network to support the growth of the ecosystem! Let's gooooo!!! 🚀
The next era of Stacks starts now. Today we welcome the Stacks Treasury Committee. A focused group to steward the Endowment, accelerate builders, and grow the Bitcoin economy on Stacks. /🧵
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Highly thought provoking article by @AmyDMarcus as she wore a suit created by @MIT_AgeLab to simulate being 80 years old. Great insights on longevity and having empathy for the elderly. Lots of opportunities for builders in this space. wsj.com/health/wellness/mit-…
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Dear 𝕏 Hivemind, I'm looking for an EA (executive assistant) who can also do marketing and account/customer support across multiple businesses. What are the best remote EA hiring platforms today? Thanks!
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This is a massive for @Stacks👇 "sBTC and STX will be deployed on Solana and Sui using NTT’s burn-and-mint mode, creating a unified supply that is managed and maintained across all supported chains with no wrapped tokens. This eliminates liquidity fragmentation, allowing for users to participate in Bitcoin-native DeFi on multiple chains while maintaining the security and decentralization advantages unique to the Stacks L2."
Stacks 🤝 Wormhole $sBTC and $STX are going natively multichain with Wormhole NTT. Wormhole will integrate @Stacks to take $1.5 billion in sBTC and STX multichain, starting with @solana and @SuiNetwork.
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Really enjoyed this conversation with @longstreetBTC And be sure to follow @signal21btc for Bitcoin ecosystem data 📊
Jonathan Sadlowe @jsadlowe drops serious alpha in this episode of The Leather Lounge. From Bitcoin treasury companies to e-commerce, healthcare, and on-chain AI tools - this is a masterclass in where Bitcoin and Stacks are headed next. 03:07 Jonathan Sadlow's Background and Journey into Bitcoin 07:02 Evolution of the Bitcoin Ecosystem and Stacks 08:29 Stacks is Winning in the Bitcoin L2 Landscape 10:23 Comprehensive Demo of Signal 21 17:52 More Use Cases for Signal 21 20:51 Current Trends: Bitcoin Yield and Treasury Companies 23:58 The Potential Unwind of the Bitcoin Treasury Companies 25:37 sBTC, DeFi, Healthcare, insurance, and RWA's on Bitcoin via Stacks 28:37 E-Commerce will be a Gamer-Changer 32:17 The Problem with Stable Coins and the Need for Market Structure 34:08 Thoughts on AI and Healthcare Innovations 38:22 It's a great time to be building in Bitcoin
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I just voted YES for @stacks SIP-031 ✅ The future of Stacks is looking bigger and brighter 🚀 You can vote at stx.eco
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SIP-31 will be rocket fuel for @Stacks - I'm a YES 🚀
What happens when you combine growth capital, sharper tooling, and strategic coordination? @jsadlowe of @signal21btc breaks down why SIP-31 is a turning point for @Stacks and how the ecosystem can compete at the highest level. Stacks Unleashed Ep 05 👇 00:00 SIP-31 and Jonathan’s Background 01:01 Why Jonathan Supports SIP-31 02:38 Three Growth Priorities: Narrative, Tools & Community 06:14 The Case for Strategic Coordination 07:34 The Magnet Effect of SIP-31
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Looking forward to this conversation!
Bitcoin-native DeFi is here - but how do we measure real growth? In this week’s Leather Lounge, Jonathan Sadlowe of @Signal21 breaks down how data tools are revealing what’s happening across Stacks and Bitcoin L2s - from wallet growth to TVL, sBTC adoption, and more.
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I’m for this ai
This quoted post is unavailable.
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Bullish
I care deeply about Bitcoin innovation. Amid all the noise, @Stacks and @Muneeb have consistently proven themselves as top Bitcoin innovators. Stacks’ new SIP-031 treasury management framework sets Stacks up for growth. Over half a billion dollars in Bitcoin is already deposited into Stacks. That's real capital flowing to where infrastructure actually works. Stacks L2 provides fast transaction speed, and manages to maintain 100% Bitcoin hashpower security. Layer 2 technology combined with a new treasury will allow stacks to compete with the largest chains. At @drapervc we are looking forward for the positive impact this will bring to Bitcoin DeFi - with @ZestProtocol leading the charge. I’ve said it before and I’ll say it again… the gravitational pull toward Bitcoin is real. The Stacks community is voting mid-June. Early support looks strong and I will be voting Yes.
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Here’s to everyone trying something new 🫡
Frank Slootman: “There’s lots of people in this world who are not really in the arena” Frank comments on why he opens his book with Theodore Roosevelt’s famous “The Man in the Arena” quote: “There’s lots of people in this world who are not really in the arena. They are either observers, consultants, agents, or VCs that provide capital. But there are some people who are in the arena, and they are very very special people.” Frank is frequently asked to speak at elite business schools, and when they invariably ask for his advice, he responds: “You all have elite educations… you’ll have many job offers paying you big bucks. Your parents and your siblings will be incredibly proud of you. But they’re all consulting jobs for Bain, McKinsey, and companies like that… You’re going to have an easy path to pretty quick earnings, but you’ll never know whether you have what it takes [to build something new].” In Roosevelt’s words, you’ll be “those cold and timid souls who neither know victory nor defeat.” Full quote from Roosevelt’s speech: “It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood; who strives valiantly; who errs, who comes short again and again, because there is no effort without error and shortcoming; but who does actually strive to do the deeds; who knows the great enthusiasms, the great devotions; who spends himself in a worthy cause; who at the best knows in the end the triumph of high achievement, and who at the worst, if he fails, at least fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat.” Video source: @FoundationCap (2024)
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Tough day. As an investor in @ALEXLabBTC and an affected user, I’m disappointed—but not disillusioned. Security is still the hardest problem in crypto (especially when you have meaningful TVL). Innovating on Bitcoin is even harder. I know the ALEX team. They’re owning the issue, moving fast, and making users whole. I’m still bullish on Stacks, sBTC, and the future of Bitcoin DeFi. It’s a long road—but it’s the right one.
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As a data nerd, I’m constantly impressed by the Arkham team. Corporations are entering Bitcoin — and with that comes a shift from traditional financial privacy to on-chain transparency. They’ll need to adapt to a new reality: Bitcoin addresses are public, and asset ownership is verifiable.
BREAKING: WE’VE IDENTIFIED EVEN MORE OF SAYLOR’S BTC - 97% OF ALL HOLDINGS We have identified an additional 53,833 BTC ($5.75B), bringing our coverage of Saylor’s Bitcoin holdings to $59.92B, almost ALL of his BTC. We are the first to publicly identify these holdings.
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Tennesseans for Bitcoin! Grateful for all that @SenatorHagerty has done for our industry 🫡
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This is a massive moment for @Stacks 👏 It just flipped BTC TVL on Lightning and Liquid "Let that sink in" 🚿 $STX
BIG BREAKING: @STACKS JUST FLIPPED LIGHTNING AND LIQUID TO BECOME THE LITERAL TOP BITCOIN LAYER!!! 🚀 🚀 🚀
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The Bitcoin ecosystem assets I like: L1: $BTC L2: $STX $CORE App/DeFi: $ALEX $DIKO $VELAR $stSTX What am I missing?
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I thought today's May 2025 update from @Stacks was very bullish 👏 My notes: 🚀The team announced a technical breakthrough in Bitcoin L2 design: self-custodial, programmable BTC with speed + UX with sBTC 📈 $1B+ TVL target, dual staking, protocol revenue = real sustainable network 🔒 Institutional onramps + SEC clarity = clear runway ⚡️ sBTC is about to scale beyond Lightning Stacks is leveling up. Lots of opportunity for Bitcoin DeFi and new Bitcoin apps through Stacks $STX $BTC
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Introducing: The New Stacks Roadmap - Stacks Value & Economy - Stacks DeFi Growth Plans - Ecosystem Growth Plan - Block production and speed - Toward Trustless sBTC - PoX 5 - Driving STX value - More Check out the full STX Roadmap: stacksroadmap.com/
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The multilayer Bitcoin economy flourishes
If you can buy pizza with Apple Pay, you can buy Bitcoin & @stacks too. Xverse (Extension) now supports: 💳 Credit/Debit Cards 📱 Apple Pay & Google Pay 💸 PayPal, Revolut, Pix & more Tap Buy, stack sats, repeat.
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"A person with a 200 IQ will come up with 100 reasons why not to buy Bitcoin." - @saylor One of the funniest things I've heard bc it's so true 😂
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