
ALT This image is a composite of six bar graphs labeled A to F, showing medical data over time. Each graph compares pre-study values with post-treatment values at 6 months and 2 years. Graph A shows systolic blood pressure. B displays plasma aldosterone-to-renin ratio. C presents plasma renin activity. D shows serum aldosterone levels. E depicts serum potassium levels, and F displays serum creatinine levels. Each graph includes mean values with error bars and sample sizes. A dotted line indicates an upper limit of normal (ULN) on certain graphs.

ALT The image contains six graphs. Graph A: The cumulative incidence of four-component primary end point of major adverse cardiovascular events (MACE) on treatment. Graph B: The cumulative incidence of three-component MACE on treatment. Graph C: The cumulative incidence of three-component MACE on treatment for composite of nonfatal MI, urgent coronary revascularization, or coronary heart disease (CHD) death. Graph D: The first and total_MACE events. Graph E: The cumulative incidence of the four-component MACE primary end point in landmark analysis with stratification of the pelacarsen group by lipoprotein(a) reduction after 3 months of treatment greater than or equal to and less than the median (170 nmol/l). Graph F: The cumulative incidence of the four-component MACE primary end point in landmark analysis with stratification of the pelacarsen group by achieved lipoprotein(a) after 3 months of treatment less than or equal to and greater than the median (69.5 nmol/l).






















