Associate professor at MIT studying host-pathogen interactions
Cambridge, MA
Joined January 2017
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Excited to share our latest work from first author @PatrickWoida. Using a novel surface display platform for expression of split TurboID, we discovered that CYLD is recruited to the Listeria surface via the effector InlC and that it supports cell-to-cell spread
Proximity labeling of the Listeria monocytogenes surface reveals pathogen control of a host deubiquitinase biorxiv.org/content/10.64898… #biorxiv_micrbio
Check out our latest paper from first author Allison Scott using a powerful enrichment strategy to enable transcriptional profiling of the early stages of a rickettsial infection
Hybrid capture RNA-seq defines temporal gene expression in Rickettsia biorxiv.org/content/10.64898… #biorxiv_micrbio
Thrilled to share our latest story from postdoc @sit_brandon! Using a functional genetic screen, he discovered an unexpected way that Rickettsia relies on the host to stabilize the Sca2 surface protein that drives pathogen motility and virulence.
Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor biorxiv.org/content/10.1101/… #biorxiv_micrbio
Becky Lamason retweeted
Cytosolic companionship: Rickettsia connects with the endoplasmic reticulum. Stacey Gilk (@sdgilk) @UNMCCOM discusses new study from Acevedo-Sánchez et al. @lamasonlab (hubs.la/Q036bFcH0) rin Spotlight: hubs.la/Q036bQTN0
#Microbiology #ER_literature
Thanks @LillianWEden for the excellent write-up about our work!
Studying the pathogen R. parkeri, researchers in the Lamason Lab discovered the first evidence of extensive and stable interkingdom contacts between a pathogen and a eukaryotic organelle @JCellBiol news.mit.edu/2025/kingdoms-c…
We are excited to kick off the new year with a new publication from the lab!
Acevedo-Sánchez et al. @lamasonlab @MITBiology characterize a novel interkingdom contact site between the ER and a cytosolic bacterial pathogen. They report that these bacteria–ER contacts (BERCs) require the tethering proteins VAPA and VAPB. hubs.la/Q031sGkq0
#Microbiology
Becky Lamason retweeted
Editor's Pick: Advancing new models is often tied to technical advances. Lamason et al. add to the toolkit for studying Rickettsia parkeri with new expression and gene silencing approaches. @ASMicrobiology @JBacteriology
journals.asm.org/doi/10.1128…
Becky Lamason retweeted
The enemy within: new research from the
@lamasonlab reveals insights into the arsenal Rickettsia parkeri uses against its host. biology.mit.edu/news-brief-l…
More publication alerts from the lab! The final version (+ some new data) of our paper using BONCAT to identify novel Rickettsia parkeri secreted effectors is out @NatureComms. nature.com/articles/s41467-0…
Amazing job by @HannahKurkaMarg! She gave a stellar talk at the ASR 2024 annual meeting today.
Becky Lamason retweeted
Ever wonder how to engineer Mtb to deliver heterologous cargo to the phagosome? Look no further!!! After trying many strategies over 6 years, we figured out a strategy. (1/10)
New preprint is out detailing the discovery of a novel interaction between Sca4 and clathrin. Great work from authors Cassandra and Brandon @sit_brandon and our collaborators Nam and Kevin from the Macaluso lab!
A conserved interaction between the effector Sca4 and host endocytic machinery suggests additional roles for Sca4 during rickettsial ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
The final version of our paper pioneering the use of inducible expression and CRISPRi tools for rickettsia is online @JBacteriology! Thanks to the reviewers and editor for their helpful feedback and effort.
journals.asm.org/doi/10.1128…
Thrilled to share our preprint on inducible expression and CRISPRi tools for Rickettsia from authors @jontmcginn, Annie Wen, @dbrinkley97, and Desmond Edwards! biorxiv.org/content/10.1101/…
Congrats to postdoc @PatrickWoida on a wonderful talk at BBM2024 exploring the host proteins interacting with Listeria!
Congrats to Yami Acevedo-Sánchez on her phenomenal defense! She presented a great story and even showed some surprise new data for the audience. Way to go!!
Thrilled to share our preprint on inducible expression and CRISPRi tools for Rickettsia from authors @jontmcginn, Annie Wen, @dbrinkley97, and Desmond Edwards! biorxiv.org/content/10.1101/…
