Mario Cabrera

Those strokes are quite serious--> one due to air embolism related to sheath. 5 clearly related to the procedure. The trial was paused and mitigation was made--no more high-risk pts (CHADSVASC > 5 excluded). After mitigation, they then had no more strokes, but in just 74 pts. Most of us ablation docs have gone years without seeing a stroke. That there were 6 speaks to a real problem with this technology. What's more there were 6 deaths in the trial 5 PFA 1 AAD. One death in the PFA group occurred at 45 days when exercise -> VF-> death. Autopsy showed no obv MI and it was called CV but unrelated to PFA. Was it? ahajournals.org/doi/10.1161/…

> 600,000 left atrial appendage devices have been placed NOT NONINFERIOR 👇🏻 Trial is large, nonindustry funded and done in experienced centers in Germany Endpoint had both efficacy and safety components and still did not make non-inferiority I tried to tell you all

Ok you all, here is my take of the CLOSURE AF trial. On @theheartorg medscape.com/viewarticle/per… Teaser: this may herald cardiology's biggest medical reversal. Nonindustry funded, non-biased trial. LAAC clearly inferior to best medical therapy (usually DOAC, but 10% no AC.) #AHA25