@masrilab

Associate Professor @UCIrvine. Interested in circadian clocks, cancer, stem cell biology, metabolism and immunology.

 Irvine, CA
masrilaboratory.com/
Joined May 2019
  • Tweets1.3K
  • Following800
  • Followers1.1K
41Media
We are recruiting! Tenure track faculty position open in the Department of Biological Chemistry @UCIMedSchool ! This is a broad search for an Assistant Professor in biomedical sciences in a vibrant department in sunny Southern California! Many perks, please apply!
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recruit.ap.uci.edu/JPF10441

Assistant Professor of Biomedical Sciences (tenure track)

University of California, Irvine is hiring. Apply now!

recruit.ap.uci.edu
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Our department website: medschool.uci.edu/research/b…
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Selma Masri retweeted
Joe Bass@JoeBass91471540Oct 1
New work from Zack Hines on a novel oxaloacetate pathway for clocks in thermogenesis and beyond!! science.org/doi/10.1126/scie…

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these...

science.org
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Pleased to finally see this out. Congratulations to all the authors and thanks to the reviewers and editors for their support during the publication journey. Especially thanks to the @The_MRC and @wellcometrust for funding and @TheCIMR and @MRC_LMB for infrastructure and support.
Science Magazine
@ScienceMagazineSep 23
A new proximity labeling and biophysical analysis shows that the protein Girdin-L is an unexpected ligand of the PDZ domain of the Dishevelled protein and plays an important role in promoting the breakdown of primary cilia on cells. @SciSignal scim.ag/4rs0gZP
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We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Nature Cancer - Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide...

nature.com
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I'm happy to share a new tool for circadian biology analysis: CODAC — Circadian Oscillation Detection, Analysis and Comparison.
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Take a look at our new study on circadian control of hepatokine secretion nature.com/articles/s41467-0…

Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock

Nature Communications - This study profiles liver protein secretion and identifies circadian-regulated hepatokines. It shows that during the inactive, fasting phase of the daily cycle, the liver...

nature.com
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Selma Masri retweeted
Avash Das, MBBS, PhD@avash22Jul 3
"All of Us" is here! nejm.org/doi/full/10.1056/NE…

The “All of Us” Research Program | NEJM

Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity, or do not provide c...

nejm.org
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Selma Masri retweeted
Peter Ly@PeterLyLabJul 2
Join us this fall for the 2026 FASEB Aneuploidy Conference! Learn about exciting science in chromosome biology, genome stability, development, and cancer + plenty of trainee talks and career development sessions. @FASEBorg #ANESRC Abstracts due August 3! events.faseb.org/event/Aneup…
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Selma Masri retweeted
Marcus Goncalves
@MarcusDGonJul 2
This study changed the way I think about cachexia. For a long time we have been looking for tumor-secreted factors that induce sickness and wasting. @ThalesPapaG now shows us that the "sickness signal" can be transmitted directly to the brain via sensory neurons. Congrats to the whole team. #CANCAN @CancerGrand @theNCI @CRUKresearch science.org/doi/10.1126/scie…

A dietary switch promotes sensory neuron–dependent cancer-associated cachexia

Sickness behaviors are common in cancer-associated cachexia and affect up to half of lung cancer patients. We demonstrate that among the most common cancer mutations, loss of liver kinase B1 (Lkb1)...

science.org
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Selma Masri retweeted
Yongsheng Shi@YongshengShiJun 26
🎉In this fun collaboration with @yeo_lab, we screened over 800 RNA-binding proteins for their activities in regulating poly(A) selection and found some expected hits! Co-led by @pratibhajagann_ from Gene's lab and @YoseopYoon in my lab. Molecular Cell cell.com/molecular-cell/full…

Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site...

Jagannatha et al. use a large-scale tethering screen to systematically identify RNA-binding proteins (RBPs) that regulate alternative polyadenylation, build a sequence-based model that predicts...

cell.com
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Selma Masri retweeted
Roberto Zoncu@RobertoZoncuJun 3
Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
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Katherine Aird@airdlabMay 27
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja! nature.com/articles/s41586-0…

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

Nature - The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential...

nature.com
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Marcus Goncalves
@MarcusDGonMay 27
New publication from our group: what happens inside human endometrial tumors during a ketogenic diet? We analyzed paired tumor biopsies before and after a very low-carbohydrate intervention in women with endometrial cancer 🧵
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Karuna Ganesh@KarunaMDPhDMay 26
We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. cell.com/developmental-cell/…🧵👇 🔗

An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies...

Mahmoud et al. establish a stable organoid biobank from primary appendiceal cancer and paired peritoneal metastases. They reveal that metastases are dedifferentiated and resistant to standard...

cell.com
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Selma Masri retweeted
Peter Ly@PeterLyLabApr 14
Pleased to share our review on chromosomal instability (CIN) and aneuploidy in cancer, led by @AmandaMennie. Now out @AnnualReviews! annualreviews.org/content/jo…

Impact of Chromosomal Instability and Aneuploidy in Cancer Development

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the...

annualreviews.org
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Selma Masri retweeted
Dr DorotaSK@DrDorotaSK24 Sep 2025
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! science.org/doi/10.1126/scit…

Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice

Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.

science.org
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Congrats! @Sunhee_Jung_ @HosungBae Wonsuk and co-authors. We reported in this @NatMetabolism intriguing effects of dietary inulin on changing small intestinal gut microbial fructose metabolism, leading to protective effects on liver. Thanks, reviewers. nature.com/articles/s42255-0…

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis

Nature Metabolism - The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

nature.com
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Very excited! Please check out our paper @NatureComms. Congrats to @Dali_XIII, @FlaviaSardela, @Geetha_Boligala, @EllieJull, & lab members for amazing teamwork. Thanks to @UNC_PHCO, @UNC_Lineberger, @TTUHSC_GSBS, and collaborators who made this possible! rdcu.be/ewwsZ
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