Mathai Mammen (@mmammen) profile picture

CEO and Chairman Designate, FogPharma. prior Exec Comm JNJ, R&D, SVP R&D, Merck, founder SVP R&D Theravance Biopharma (TBPH), Innoviva (INVA)

New Hope, PA
Joined September 2008
Photo by Mathai Mammen (@mmammen)
On the 27th straight day of filming “Forrest Gump,” Tom Hanks was tired & worried. During a scene on the famous park bench, Hanks stopped & said to director Bob Zemeckis, “Hey, Bob…is anybody going to care about this movie? I don’t think anybody’s going to care.” Bob replied, “It’s a minefield, Tom. You never know what’s good…It’s a minefield! It’s a goddam minefield! We may be sowing the seeds of our own destruction.” Tom Hanks told this story after he was asked, “When I ask for a memory from your career, what’s the first thing that comes to mind?” He said that what Zemeckis said was true of every movie he’s worked on: “There’s never any guarantee...You do not know if it is going to work out.” Takeaway 1: Hanks is the 5th-most highest-grossing actor of all time. And yet, the stickiest memory of his career is the feeling of uncertainty. Rarer than talent or work ethic, the poet John Keats wrote, is the ability to step into and push through doubts and uncertainties. In 1817, Keats wrote a letter to his brothers to share this exciting realization. “At once it struck me,” Keats wrote, “what quality went to form a Man of Achievement … Negative Capability.” Keats explains that “Negative Capability” is “when a man is capable of being in uncertainties, mysteries, doubts, without any irritable reaching after fact and reason.” Takeaway 2: Those who possess Negative Capability, who can sit with uncertainty, who can spend months or years in the minefield that is working on something while knowing that there is a real possibility no one will care about it—they often possess another quality. They do what they do, not as a means to some end (money, fame, awards, etc.), but for the sake of doing it. When asked about one of his movies that commercially failed, Hanks said, "I loved making that movie. I loved writing it, I loved being with it. I love all the people in it." As Ryan Holiday once told me, "The work has to be the win." You control the effort, he says, not the results. "So ultimately, you have to love doing it. You have to get to a place where doing the work is the win and everything else is extra.” - - - “Life is like a box of chocolates: you never know what you're going to get.” — Forrest Gump Follow @bpoppenheimer for more content like this!
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Congratulations on another submission of an important potential medicine linkedin.com/posts/activity-…
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NEW: I’m not sure people appreciate quite how bad the Covid situation is in Hong Kong, nor what might be around the corner. First, an astonishing chart. After keeping Covid at bay for two years, Omicron has hit HK and New Zealand, but the outcomes could not be more different.
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Mathai Mammen retweeted
The real death toll from the pandemic is 3 to 5 times higher than what has been reported, and the excess mortality is especially pronounced among low and middle income countries @Nature nature.com/articles/d41586-0…
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Mathai Mammen retweeted
In just a week, 6 new studies have now reported how T cells, induced from multiple vaccines or prior Covid, hold up quite well vs Omicron (i.e. they exhibit cross-reactivity), which should help protect vs severe disease
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I also explained this morning why JNJ is also a really good vaccine based on new data this AM. I felt like Kris Kringle in Miracle on 34th Street, sitting Macy’s but also touting the benefits of Gimbel’s…if you know what I mean. Whatever helps humanity! – at Houston, TX
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Mathai Mammen retweeted
Why does this bode well for Omicron? Beta has the most immune escape of the variants of concern. The booster crushed it. Not seen here, but established, is the augmented breadth of antibody response (binding more epitopes) Please get a 3rd 💉 if it's time
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Mathai Mammen retweeted
Big (order of magnitude) 3rd shot impact of J&J or Pfizer vaccine after 2 doses of Pfizer for both neutralizing antibody and T-cell response vs Delta medrxiv.org/content/10.1101/… confirms powerful booster effect and extends to J&J, cellular immune response
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Mathai Mammen retweeted
We needed some good news for this vaccine. This is it. No sign a booster vs Delta is necessary (study is limited by small number of participants) @FT by @nikasgari
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Just out @NEJM New data for J&J vaccine: —High titers of neutralizing antibody to Delta variant, improvement in these levels seen over time —The antibody and T cell response was durable for at lest 8 months nejm.org/doi/full/10.1056/NE…
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Today, we received FDA approval of a targeted unique bispecific therapy for patients with genetically defined metastatic #NSCLC. Thank you to the patients & the medical staff that partnered with us & our dedicated colleagues across Janssen! #lcsm prnewswire.com/news-releases…
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