Rohan retweeted
Dr. Tim Henrich presented new findings surrounding long term persistence of SARS-CoV-2 proteins & RNA in Long COVID gut tissue at PolyBio’s recent Spring symposium. “We actually see [gut viral persistence] in both areas, the epithelium—which turns over every several days to week—to the lamina propria where you have long-lived myeloid immune cells… suggesting there may even be replication in some individuals,” said Henrich.
Using a highly sensitive method of detecting viral RNA, “around 20-25% of the time, we see detection… all the way up until 3-4 years after initial infection” in Long COVID patients.
Rohan retweeted
People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.
Why Covid could be to blame for the rise in deadly meningitis, according to scientists - and the early symptoms of the disease that patients must act on trib.al/XW4xOX8
Rohan retweeted
Lots of clinical trials for Long COVID coming out. Here's a quick guide on how to assess it.
A study is getting quite a bit of coverage, suggesting that the antidepressant fluvaxamine is effective for Long COVID. We'll use it as an example.
acpjournals.org/doi/10.7326/…
Rohan retweeted
National Taiwan University researchers analyzed data from over 97 million individuals and found that COVID-19 is linked to a 49% higher risk of developing autoimmune diseases.
The risk rose after severe infection but dropped by 44% in vaccinated people.
link.springer.com/article/10…
Rohan retweeted
A new RECOVER study of 6.4M health records shows Long COVID risk has not decreased from 2020–2024. Incidence stayed stable across variants, reinforcing Long COVID as an ongoing public health priority.
Read the study: doi.org/10.1093/cid/ciaf046
ALT New Study: Long COVID Risk Has Not Decreased Over Time Image of a virus (Arrow pointing right) Small Citation
Rohan retweeted
Urine tells the story of #LongCOVID:
➡️ New study identifies a molecular fingerprint for #LongCOVID (PASC) — using just a urine test.
➡️ Researchers found 195 urinary peptides that can accurately distinguish Long COVID patients from healthy and ME/CFS controls (AUC > 0.95). 1/
Rohan retweeted
Diagnosis and characterization of people with #MECFS (vs controls) using circulating cell-free RNA, indicative of immune system dysfunction and pro-inflammatory cytokine signaling pnas.org/doi/10.1073/pnas.25…
Rohan retweeted
🔬New @BhupeshPrusty paper breakdown - very cool paper:
The study finds that people with ME/CFS & Long COVID have antibodies in their blood that may directly interfere with mitochondria (how human cells create energy and regulate inflammation)
In simple language all findings 🧵
Rohan retweeted
"the growing body of research suggesting that for several months after a Covid infection, people become more vulnerable to other infections and there can be lingering effects on the heart, cardiovascular system and the brain"
¯\_(ツ)_/¯
theguardian.com/world/2025/a…
Rohan retweeted
Important paper by the European Academy of Neurology. "Healthcare systems should be aware of, and be prepared for a potential increase in the incidence of neurodegenerative diseases in the upcoming years."
What has been the state of surveillance and awareness so far? #NeuroCovid
Rohan retweeted
Just out in Nature yesterday, SARS-COv-2 infection can awaken sleeping cancer cells! My concern mounts with increasing evidence that COVID is a cancer inducing virus. Viral clearance is more important than ever, especially in those with LONG-COVID.
nature.com/articles/d41586-0…
Rohan retweeted
⚡️Thrilled that #VirtualLab is published in @Nature! nature.com/articles/s41586-0…
We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
The Virtual Lab is open source and can be applied to many problems! github.com/zou-group/virtual…
👏Great job @KyleWSwanson John Pak, Wes Wu, Nash Bulaong @czbiohub @StanfordAILab @StanfordHAI
Rohan retweeted
Researchers in Germany and France analyzed over 90,000 biomedical links and found strong evidence that COVID-19 and neurodegenerative diseases like Alzheimer’s share inflammatory and genetic pathways, suggesting common biological roots.
biorxiv.org/content/10.1101/…
Rohan retweeted
Young doctors in England are getting sicker - and fast.
For decades the levels of sickness absence of NHS Staff were stable, until Covid infections arrived.
Now, in all three of these groups, sickness absence rates have *more than doubled*.
And they're STILL CLIMBING.
Rohan retweeted
Yale immunologist Dr. Akiko Iwasaki to probe monoclonal antibodies for Long COVID and post-vaccine syndrome, aiming to test if spike protein persistence drives symptoms and if targeted antibodies can offer relief.
investors.invivyd.com/news-r…
Rohan retweeted
Researchers in Japan discovered S-892216, a second-generation COVID-19 drug that blocks the virus’s main protease with 30 times the potency of ensitrelvir, works against major variants, and avoids cross-resistance seen with existing antivirals.
pubs.acs.org/doi/10.1021/acs…
Rohan retweeted
"SARS-CoV-2-encoded genomes (entire or fragments) and proteins have been detected in different brain regions of infected persons..
Even in the absence of active viral replication, microglial activation, dysregulation of neural cells, infiltration of T-cells and monocytes into the brain parenchyma, induction of inflammatory response by cytokine production and blood–brain barrier (BBB) disruption have been reported..
These findings suggest that the mere presence of virus-encoded genomes or proteins in the brain might activate neuroinflammatory responses..
[This study indicated that] neuropsychiatric impairments during SARS-CoV-2 infection might be driven by IL-6 mediated effects that increase MAO (monoamine oxidase) expression and activity."
SARS-CoV-2 genomes or proteins are thought-stopping agents.
'Immunometabolism perturbations in post-COVID-19 condition: interleukin-6 and monoamine oxidase interactions drive neuropsychiatric syndromes'
sciencedirect.com/science/ar…
Rohan retweeted
New brain MRI study (2025): Post-COVID patients show measurable structural changes - even without hospitalization.
Participants were not selected for having Long COVID!
What was found, why it matters, and how this fits into what we know about hypothalamus-related circuits. 🧵
Rohan retweeted
Polybio is launching VIPER: a biomarker validation program for viral persistence
150 people will undergo gut biopsy, and fluid specimens will be collected twice weekly for four weeks
ALT Slide on VIPER from Stephen Deeks' talk at the Polybio Spring 2025 symposium - central analysis across multiple labs of one cohort
