Rene Sugar retweeted
Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline
onlinelibrary.wiley.com/doi/…
Rene Sugar retweeted
STAT3 with a patient-derived substitution causes immune dysfunction by sequestering wild-type STAT3
science.org/doi/10.1126/scis… @scisignal @GarvanInstitute @stutangye 🇳🇿
Rene Sugar retweeted
Inflammatory exposure (IFN-γ) and cellular plasticity imprint a lasting transcriptional and epigenetic memory on intestinal stem cells and their progeny, priming them for enhanced repair after subsequent injuries
nature.com/articles/s41467-0… @NatureComms @idibell_cat @GuiuLab
Rene Sugar retweeted
Pantethine may boost psoriasis treatment: in a 24-patient trial, symptoms improved over 12 weeks when the supplement accompanied a topical ointment, particularly in patients with high cholesterol. @RockUPress @JExpMed medicalxpress.com/news/2026-…
Rene Sugar retweeted
After being clobbered by 10ml milk kefir in March, I decided to try again with water 💧 kefir this time after reading that it’s significantly weaker than the milk based kinds.
Again, it did sedate me but it lasted just a few hours and wasn’t as strong.
I got absolutely *clobbered* by just 15ml of kefir today. This was all I had ⬇️ within an hour I felt intense fatigue sinking in, by 3 hours I couldn’t open my eyes, or feed myself it was so intense. Had to have a Huel for food. Turns out, kefir is high in GABA 😴
ALT A cough syrup measuring cup with 15ml@of kefir in
Rene Sugar retweeted
Why does cold extend lifespan? 🥶 In worms, cold boosts BH2 made in muscle. It travels to gut and neurons, becomes BH4 and drives tyrosine synthesis, extending life and curbing protein aggregation. In human cells, BH2 cut Huntington's and ALS aggregates.
nature.com/articles/s41586-0…
Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis
go.nature.com/4BuXDLz
Rene Sugar retweeted
Semaglutide doesn't just curb appetite - it changes gut bacteria in ways eating less can't explain 🧫🐀. Dive into the surprising microbiome shifts seen in both male and female rats: news-medical.net/news/202610… #Semaglutide #Microbiome
Rene Sugar retweeted
I’ve seen success in amelioration of fatigue with higher dose valacyclovir twice a day a subset of patients w MS or long covid/Neurocovid. Pts w hx of EBV/mono esp. pmc.ncbi.nlm.nih.gov/article… pmc.ncbi.nlm.nih.gov/article…
Rene Sugar retweeted
Cells make toxic metabolites every minute they’re alive. How do they survive them?
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/scia…
Identification of hACE2-interacting sites in #SARSCoV2 Spike Receptor Binding Domain for Antiviral Drugs Screening #MECFS #LongCovid
sciencedirect.com/science/ar…
"Moreover, Cefixime inhibited live SARS-CoV-2 infection."
Molecular docking and dynamic simulations of Cefixime, Etoposide and Nebrodenside A against the pathogenic proteins of SARS-CoV-2
sciencedirect.com/science/ar…
Celiac disease manifested by polyneuropathy and swollen ankles #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/article…
Rene Sugar retweeted
A new oral peptide called Icotrokinra completely cleared psoriasis in 27% of patients after 16 weeks.
And 50% saw at least 90% improvement.
All from a once-daily pill!
Circulating cholesterol fuels #SARSCoV2 replication via ORF3a #MECFS #LongCovid
link.springer.com/article/10…
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
nature.com/articles/s41392-0…
Rene Sugar retweeted
SARS-CoV-2 can directly link its replication to host cholesterol levels via ORF3a
link.springer.com/article/10…
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Viruses may be minuscule, but one could have influenced major differences between human and chimpanzee brains.
sciencenews.org/article/huma…
Rene Sugar retweeted
A possible culprit hiding around the urethra could help explain the most common prostate problem in men over 50. 🔗 sciencealert.com/scientists-…
ALT Scientists May Have Discovered Why Men's Prostates Enlarge With Age
Rene Sugar retweeted
Could a bladder medicine choice matter for brain health?
In older women with overactive bladder, anticholinergic meds were linked to a 49% higher risk of claims-defined dementia vs β3-agonists. No difference in long-term care needs or frailty.
What brain-health meds have you heard about lately?
Rene Sugar retweeted
Doctors learned inflammation could change mood by accident in the 1980s.
Interferon alpha was used for chronic hepatitis, and some people on the highest doses quickly developed depression, agitation, emotional swings and even paranoia. Lowering the dose made the psychiatric side effects go away.
That history still explains sickness behavior today. When you fight a virus you get tired, irritable and want to be left alone, which is a useful short term response.
The problem is when those same signals stay on for months. TNF and IL6 variants are part of why some people seem more sensitive to that shift. 👇
geneticlifehacks.com/is-infl…