Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
La Jolla, CA
Joined September 2012
- Tweets6.9K
- Following559
- Followers283K
- Likes3.2K
Scripps Research has named Ron Burkle, founder and managing partner of The Yucaipa Companies, chair of its Board of Directors. A board member since 2017, Burkle brings business and investment experience and a longstanding commitment to philanthropy and nonprofit leadership.
More: ow.ly/PXU650ZZRRt
Scripps Research retweeted
Discovery often comes from putting familiar pieces in unexpected ways: but bio space is too vast to do that effectively?
🤖 1000s of AI agents helped connect our whole-brain Perturb-seq atlas w literature. w @OpenAI @joyjiao12: more coming! See preprint biorxiv.org/content/10.64898…
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
Scripps Research retweeted
8 million brain cells. 32 minutes. A new frontier in medicine.
In less than a year, PerturbAI built a proprietary AI-native drug discovery engine, created 6 genomic maps, revealing how genes influence health and disease in living systems.
Now, together with @OpenAI and @ScrippsResearch, we've uncovered 11,000 biological insights and ~100 promising leads using frontier AI in just 32 minutes.
We're expanding our partnership into drug-target discovery, bringing us closer to understanding disease and developing new medicines.
Better biology. Better targets. Better medicines.
Learn more: perturb.ai/news/perturbai-la…
Read the full blog here: openai.com/index/scaling-ai-…
Scripps Research retweeted
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
Scripps Research retweeted
My @scrippsresearch colleague @xinjin and her team are doing amazing brain biology discovery work with 2,000 agents, PerturbAI, in collaboration with @OpenAI
prnewswire.com/news-releases…
Tomorrow, Scripps Research professors John Yates III and Jeffery Kelly, both 2026 Canada Gairdner International Award laureates, take the stage at #GairdnerScienceWeek. The free event, hosted by @GairdnerAwards, will be livestreamed. Register: bit.ly/laureatelectures2026
Congratulations to Scripps Research science writer Melissa Suran, whose story “Life beyond Crohn’s disease” received an honorable mention in the short-form category of the 2026 National Association of Science Writers Excellence in Institutional Writing Awards!
The national awards recognize high-caliber, publicly accessible science writing produced on behalf of an institution. Published in Scripps Research Magazine, Suran’s story follows Gary Jacobson’s decades-long experience with Crohn’s disease and the pioneering treatment he received from Scripps Research physician-scientist Amy L. Lightner MD, MBA.
📲 See the full list of 2026 honorees:
ow.ly/xMZ250ZXopx
📄 Read the recognized story:
ow.ly/JTqk50ZXopz
It's #NationalChemistryWeek! 🧪✨ We’re highlighting how the Scripps Research Department of Chemistry seeks to understand matter, create new forms of matter and translate new discoveries into useful products.
Learn more about chemistry at Scripps Research: ow.ly/Nr6u50ZZ6gb
Scripps Research today received 14M+ compute hours from the Jen-Hsun and Lori Huang Foundation. Led by @WardLab1, the grant also supports @bryanbriney and @ForliLab on a virtual human immune system and the “dark” proteome, with data from @_chrisgparker_ and Benjamin Cravatt.
More: ow.ly/gOzA50ZZ2iJ
Follow along on our Discovery Day scavenger hunt! 🗺️🔬
We stopped at each booth and had so much fun making fascinating discoveries along the way. We can’t wait to do it all again next year! 💙
#ScrippsResearch #DiscoveryDay #scienceexperiments #sciencefair #STEM
More smiles from this year's Discovery Day! 🤩 Our graduate students and postdocs had so much fun meeting everyone, answering questions and sharing science through hands-on activities.
Next week, the 2026 Scripps Research Biotech Innovation Summit will bring together leaders from science, technology and venture capital to explore how AI is reshaping biomedical discovery.
We are thrilled to welcome @ThomasOrTK, CEO of @googlecloud, and Jorge S. Reis-Filho, MD, PhD, FRCPath, Chief Strategy Officer and Operating Partner at @ForesiteLabs and Venture Partner at @ForesiteCapital, for our featured keynote conversation.
We are also pleased to welcome these powerhouse guest speakers to the Summit stage:
- @joyjiao12, PhD, Life Sciences Research Lead at @OpenAI
- Stacy Feld, JD, Global Head, External Scientific Innovation at @JNJNews
- Alicia Chung, PhD, Venture Advisor at @MagnetVentures
- Sarah Nam, MBA, Vice President, Global Head of AI Partnerships at @abbvie
- @gracexyzheng, PhD, Co-founder and CEO at @perturbai_tx
- @soniasethh, PhD, Partner at @CivilizationVC
Guiding these conversations will be moderators Leighanne Oh, MS, Vice President at Ascenta Capital; Nancy Hong, PhD, Managing Partner at HiTide Venture Capital; and @bryanbriney, PhD, Professor at Scripps Research.
🗓️ October 22, 2026 | Scripps Research, La Jolla
📲 View the program and request to attend: techsummit.scripps.edu/
“Fearless” is the word Laura Nicholson picks to describe the next generation of clinical and translational scientists. As a physician and director of education at the Scripps Research Translational Institute, she sees her job as helping her trainees tap into their passion and realize their potential.
Read more in our latest Community Corner: ow.ly/4ycu50ZXjvp
Scripps Research invited the local community to its La Jolla campus on October 3, 2026 for the institute’s third annual Discovery Day outreach event. This was the first year the event was held on campus, giving visitors of all ages a chance to engage with our scientists in the very place where they pursue their research.
More than 70 Scripps Research graduate students, postdoctoral scholars and other volunteers shared the excitement of scientific discovery at more than a dozen hands-on activity tables. Visitors experienced demonstrations on topics ranging from chemistry, neuroscience, genetics, viruses and vaccines, cell biology and more.
In today's Front Row lecture, Diercks will go deeper into how T7-ORACLE turns bacterial growth into a continuous search for potential new protein medicines.
🗓️ Join us Wednesday, October 19, at 4:00 p.m. PT | 7:00 p.m. ET.
🎟️ Free and open to the public in-person or online
🔗 Register now: ow.ly/GnX350ZXPvf
At Scripps Research, Assistant Professor Christian Diercks (@DiercksLab) is turning bacterial growth into a continuous protein-evolution experiment.
His lab’s T7-ORACLE platform adds an independent DNA-copying system to E. coli. As the bacteria divide, T7-ORACLE continually mutates a separate circle of DNA carrying a selected gene, generating protein variants without increasing the mutation rate of the bacterial genome. This replaces repeated rounds of manual DNA manipulation with continuous variation and selection inside growing cells.
Diercks’ lab is using T7-ORACLE to pursue therapeutic enzymes, highly specific binding proteins and new technologies for genetic-code expansion. Research directions include reprogramming the protein-cutting enzyme from botulinum toxin—the substance used in Botox—to recognize disease-related targets in pain, as well as developing non-addictive alternatives to opioid-based pain treatments.
According to @WHO, cancer causes nearly 1 in 5 deaths worldwide. Scripps Research scientists study cancer from individual proteins to whole cells and tissues, uncovering vulnerabilities and advancing promising ideas toward new therapies. Learn more: ow.ly/z4kk50ZXiV0 #BreastCancerAwarenessMonth
Scripps Research retweeted
Join Jeffery Kelly to explore how his research on protein aggregation led to the discovery of tafamidis, the first effective drug for slowing the progression of a human amyloid disease.
📆Oct 22 | 9AM ET
📍Toronto & Online
🎟️Free
🔗bit.ly/InternationalSymposiu…
#GairdnerScienceWeek
Scripps Research alum Linda Kidd, DVM, PhD, has received the 2026 @uwvetmed Alumni Achievement Award, recognizing her contributions to veterinary medicine, biomedical science and the broader community.
More: ow.ly/2RBR50ZWZEV
