@yxsetoh

Medical Lead, Vaccines at Takeda. Asst Prof (adj.) at NUS ID-TRP. Tweets=mine.

 Singapore
pubmed.ncbi.nlm.nih.gov/?term=Setoh+YX&sort=date
Joined April 2008
  • Tweets1.7K
  • Following484
  • Followers747
125Media
Protection is invisible when it succeeds — and unforgettable when it doesn't. Just like vaccines.
Dad Jokes
@DadsaysjokesJan 20
Eyelashes are supposed to prevent things from getting into your eyes, but whenever I have something in my eye it's always an eyelash. Eyeronic
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Dengue doesn’t just make you sick — it can reprogramme your immune system, leaving a lasting imprint not seen with vaccines. A new study by #DukeNUS & collaborators reveals how: duke-nus.edu.sg/newshub/medi… 📸: istock #DengueResearch #VaccineDevelopment @EngEongOoi
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🚨 We found some cool viruses in Singapore!! 🚨 Over 18 months, we screened 17,070 🦟mosquitoes across 17 locations in Singapore, uncovering 🦠viruses that could shape future biocontrol strategies against dengue and other arboviruses! 🔗: doi.org/10.1099/jgv.0.002105 🧵👇 (1/)
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Exciting work coming from the ⁦@JodyPeters20⁩ lab! C6/36 cells can be grown as a suspension culture to efficiently produce ISF chimera vaccines. Congrats everyone!! mdpi.com/1999-4915/17/2/250

Serum-Free Suspension Culture of the Aedes albopictus C6/36 Cell Line for Chimeric Orthoflavivirus...

Chimeric orthoflaviviruses derived from the insect-specific Binjari virus (BinJV) offer a promising basis for safe orthoflavivirus vaccines. However, these vaccines have so far only been produced...

mdpi.com
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JCI Insight - Frequency of dengue virus–specific T cells is related to infection outcome in endemic settings insight.jci.org/articles/vie…
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Thank you TWIV @profvrr for discussing our paper which was recently published in @NatureMicrobiol - We showed that T cells were able to control viral infection independent of NAbs in humans @EngEongOoi @Anto_Berto @bertoletti_lab @dukenus @mysgh nature.com/articles/s41564-0…

Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing...

Nature Microbiology - The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and...

nature.com
MicrobeTV@profvrr2 Feb 2025
TWiV notes the HHS communication pause, describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, & more! 📺 bit.ly/3WJVF7l
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#DukeNUS Prof Ooi Eng Eong (@EngEongOoi) and a @mysgh team found T cells can fully block viral infections, challenging the idea that this was mainly the role of neutralising antibodies. Read more: duke-nus.edu.sg/newshub/medi… #Immunology #Research #Vaccines

T cells’ capability to fully prevent acute viral infections opens new avenues for vaccine develop...

T cells can independently prevent acute viral infections to an extent previously thought only possible with neutralising antibodies.Findings challenge the longstanding reliance on neutralising...

duke-nus.edu.sg
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Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans | Nature Microbiology ⁦@shirinklmddn⁩ ⁦@Anto_Berto⁩ @bertoletti_lab⁩ ⁦@kuanrongchan⁩ nature.com/articles/s41564-0…

Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing...

Nature Microbiology - The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and...

nature.com
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#France #Dengue Locally acquired dengue cases have risen to 85 as of 11/5/24. This is the most cases reported in a single year.
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Re-posting this 4 years later, as it remains as relevant as ever We need leaders that believe in scientific evidence So much is at stake, next week in the USA and right now all over the world @PLOSBiology journals.plos.org/plosbiolog…

We need leaders that believe in scientific evidence

In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time.

journals.plos.org
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Excited to share the first paper from the PhD of @mikaelagbell . Mikaela meticulously re-created the Australian insect-specific alphavirus, Yada Yada virus – one of only 5 insect-specific alphaviruses discovered to date. nature.com/articles/s44298-0…

Synthetic recovery of Yada Yada virus expands insect-specific alphavirus knowledge and facilitates...

npj Viruses - Synthetic recovery of Yada Yada virus expands insect-specific alphavirus knowledge and facilitates production of chimeric viruses

nature.com
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WHO launches global strategic plan to fight rising dengue and other Aedes-borne arboviral diseases who.int/news/item/03-10-2024…

WHO launches global strategic plan to fight rising dengue and other Aedes-borne arboviral diseases

Today, the World Health Organization (WHO) launched the Global Strategic Preparedness, Readiness and Response Plan (SPRP) to tackle dengue and other Aedes-borne arboviruses.

who.int
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Viral and cellular determinants of polarized trafficking of viral envelope proteins from insect-specific and insect-vectored viruses in insect midgut and salivary gland cells | Journal of Virology journals.asm.org/doi/10.1128…

Viral and cellular determinants of polarized trafficking of viral envelope proteins from insect-s...

Viruses that use insects as hosts must navigate specific routes through different insect tissues to complete their life cycles. The routes may differ substantially depending on the life cycle of the...

journals.asm.org
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New in @ScienceTM : A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes A thread: 1/5 science.org/doi/10.1126/scit…

A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in...

Evolution of dengue virus type 2 in Tonga may be explained by a single mutation in a viral gene encoding premembrane protein.

science.org
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Visiting Institut Pasteur in Ho Chi Minh City. Such a beautiful campus. – at Ho Chi Minh, Vietnam
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Research focus: the Paediatric Dengue Cohort Study pubmed.ncbi.nlm.nih.gov/3900…

Research focus: the Paediatric Dengue Cohort Study - PubMed

Research focus: the Paediatric Dengue Cohort Study

pubmed.ncbi.nlm.nih.gov
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Sous vide cow juice to be *exact* – at North-East Region, Singapore
This Post is from an account that no longer exists. Learn more
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Increased Risk of Dengue Virus Infections in the United States emergency.cdc.gov/han/2024/h…
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Another country announcing a national health emergency for a #dengue outbreak. This time Honduras: thelancet.com/journals/lanin…

Infectious disease surveillance update

On May 31, 2024, government authorities in Honduras declared a national health emergency due to the increase in hospitalisations for dengue virus disease and an increase in cases across all departm...

thelancet.com
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