Chad Dean

Dear @Nature, I am baffled by the monumental mistake about the "definition" of what lactate is, which is shown right in the 1st sentence of this article. -Lactate is NOT a waste product. Thanks by the work of Dr. George Brooks, It has been known for over 40 years that lactate is NOT a waste product. In fact, lactate is the preferred fuel by most cells and one of the most important signaling molecules in the body. Particularly in cancer, lactate plays a key role in the process of angiogenesis, immune scape, gene expression and metastasis... -"Sugar"?. Are glucose and pyruvate metabolism, some of the most complex metabolic pathways in humans, be that poorly simplified as "sugar"?. 😬 -"without Oxygen"?. Again, Thanks to the work by George Brooks, it has been known for >40 years that Lactate can be produced under FULLY aerobic conditions and it's production is NOT only a result of lack of O2.... It is extremely difficult to publish in Nature due to its super high standards and requirements, such as defining what you are studying very well...However, in this article, the are 3 monumental mistakes showing lack of knowledge of what exactly lactate is right in the very first sentence...Now, many people reading the article could walk away with the idea that lactate is a waste product from sugar and produced when there is lack of O2...😬 C'mon @Nature, you, your Editor and reviewers can do better than this...Thank you