Assistant professor at Dalhousie University. We study physiology, cell biology, and biochemistry of the retina. Opinions are my own.
Halifax, NS
Joined April 2022
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Melina A. Agosto retweeted
New results explain mGluR6 dysfunction in congenital stationary night blindness @DalhousieU @AgostoLab life-science-alliance.org/co…
Melina A. Agosto retweeted
Warm conformation of the calcium-activated nonselective cation channel TRPM4 driven by a temperature-dependent calcium-binding site. nature.com/articles/s41586-0…
Melina A. Agosto retweeted
Researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/6WK
Melina A. Agosto retweeted
🚀 Exciting opportunity! Our lab at Rutgers University is now hiring a postdoctoral researcher. Join us to explore the mysteries of the somatosensory system using cutting-edge molecular genetics. Apply now! 🧬🔬 abrairalab.org/join-our-team…
Melina A. Agosto retweeted
Our lab's super-resolution #microscopy analysis of #rhodopsin in the complicated/hard-to-reach #photoreceptor inner segment compartment is now published in @PLOSBiology !! 🔬👁️
Special thanks to all co-authors, including @AgostoLab
Retinal #photoreceptor cells are maintained through a complex #ProteinTrafficking network. @RobichauxLab use quant super-res microscopy to reveal trafficking of the visual pigment #rhodopsin in the inner segment region of rod photoreceptors #PLOSBiology plos.io/3RPJPVW
Melina A. Agosto retweeted
ICYMI, we recently unveiled the first cellular map of a mammalian brain in @nature. 🧠✨
Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals amazing diversity & regional specificity.
More: alleninstitute.org/scientist…
#studyBRAIN
Melina A. Agosto retweeted
For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron. #12DaysOfeLife elifesciences.org/articles/8…
Melina A. Agosto retweeted
#eNeuro | Ultrastructural Characteristics and Synaptic Connectivity of Photoreceptors in the Simplex Retina of Little Skate (Leucoraja erinacea) eneuro.org/content/10/10/ENE…
Melina A. Agosto retweeted
Thrilled to share the latest work from my time at #BCM in Ted Wensel’s lab and with @AgostoLab, ‘Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography’ giving us a closer look at the CC, including y-links! biorxiv.org/content/10.1101/…
Melina A. Agosto retweeted
In @Nature today (open access), we report the structural and mechanistic basis of how bacteria harvest energy from air. We reveal a novel enzyme, Huc, consumes atmospheric levels of hydrogen gas and transfers the derived electrons for aerobic respiration. nature.com/articles/s41586-0…
Melina A. Agosto retweeted
Dense network mapping in the human cortex has revealed a large interneuron-to-interneuron network that is almost absent in the mouse. This novel neuronal network may constitute a key evolutionary invention in the human cortex. scim.ag/14B #ScienceResearch
Melina A. Agosto retweeted
New in JBC press: "The S-layer Deinoxanthin-Binding Complex (SDBC) is active in quenching oxidative conditions and bridges the cell envelope layers in Deinococcus radiodurans."
Learn more:
jbc.org/article/S0021-9258(2…
ALT Figure 1. Structure of the SDBC collar and DR_0644 model.
Melina A. Agosto retweeted
Not your typical GPCR: Using single-particle #cryoEM, researchers in a new Science study found structures of an unusual receptor assembly between an orphan G protein–coupled receptor complexed with a signaling regulator. science.org/doi/10.1126/scie… #ScienceResearch
Melina A. Agosto retweeted
The first two CubeSats from the Canadian CubeSat Project are set to launch to the Space Station today!
Congratulations to the teams from Dalhousie University (@loris_nano) and University of Victoria (ORCASat)!
Watch the launch here starting at 2pm ET: nasa.gov/nasatv
ALT From left to right: LORIS CubeSat from Dalhousie University, ORCASAT from the University of Victoria, and the University of Victoria's engineering CubeSat model.
Melina A. Agosto retweeted
Our paper is out today @NatureNeuro. We find a new player controlling mu-opioid receptor trafficking via effects on cholesterol: Ptchd1. Mice lacking Ptchd1 do not develop opioid tolerance and their neurons don't desensitize.
nature.com/articles/s41593-0…
Melina A. Agosto retweeted
#OTD 15 years ago, Hubble snapped this shot of Uranus.
This rare view shows the planet’s faint rings edge-on, seen as two spikes above and below the planet.
Uranus’s rings can only be seen edge-on every 42 years, since its orbit takes 84 years: go.nasa.gov/3w32UtH
ALT Uranus is seen in blue hues with its pale rings appearing as two spikes above and below the planet.
Melina A. Agosto retweeted
DeepMind and EMBL-EBI have released the predicted structures of over 200 million proteins covering almost every organism that has had its genome sequenced.
These are now openly available to the scientific community via the AlphaFold Database.
embl.org/news/technology-and…
Melina A. Agosto retweeted
This study investigated how cell shape and the motility of individual cells influence how macrophages scan for signs of infection. elifesciences.org/articles/7…
Melina A. Agosto retweeted
Growing microtubule plus-ends (EB3, orange) and endoplasmic reticulum (KDEL, blue) in a cultured cell. 6 min movie acquired at ~ 1 fps. #TubuleTuesday