Astrid Linde Basse (@AstridBasse) profile picture

Astrid Linde Basse

@AstridBasse
 Copenhagen
Joined March 2023
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Every cell in our body contains its own clock that helps us keep biological rhythms. Our work on tissue-specific regulation of metabolic rhythmicity and the core clock by NAMPT is out today in @PNASNews pnas.org/doi/10.1073/pnas.22…
NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner | PNAS

NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner | PNAS

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracell...

pnas.org
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7/ This project has been an on-going team effort at @Metabolcenter for the last 7 years. Thanks to collaborators @JuleenRZierath, @Romain_Barres, and @M3_Faergeman….
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8/ …and current and former colleagues in the @treebak and @Z_GerhartHines Labs, in particular @karen_rgaard, and @IuliiaKaravaeva
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5/ Our work highlight, that by investigating how specific clocks are programmed in different cells, we will better understand how our billions of clocks are set and how circadian misalignments across our tissues leads to numerous diseases, from diabetes to neurodegeneration.
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6/ Moreover, this line of research may uncover targets to precisely correct circadian biology in particular cell types, which might ultimately represent more attractive and safer approaches than directly manipulating our core clockwork.
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