#DHPSP brings together individuals and organizations interested in #DigitalHealth, #PersonalizedMedicine, and #PatientSafety. Administered by @_atanas_

Joined May 2020
Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine digitalpatientsafety.com/imp… #DigitalHealth #PatientSafety #PersonalizedMedicine #HospitalsTalkToLovedOnes
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Reprogramming NOX4-associated ferro-aging w/an iron-chelating senescent-cell-targeted therapy for intervertebral disc degeneration ▶️ Intervertebral disc degeneration (IVDD) has been a major contributor to chronic low back pain. ▶️ It was identified a NOX4-associated ferro-aging program in IVDD linking iron overload, oxidative stress, lipid peroxidation, & cellular senescence in degenerative nucleus pulposus cells (NPCs). ✅️ SenoFAN (a ferro-aging-cell-adapted therapeutic platform that combines iron chelation, nanozyme-mediated ROS regulation, Amen-mediated NOX4-dependent suppression of NADPH oxidase activity, & NKG2D-engineered membrane preferential accumulation) attenuates IVDD through preferential accumulation in ferro-aging-associated NPCs & multimodal remodeling of the ferro-aging microenvironment. sciencedirect.com/science/ar… @DHPSP @Mangan150 @nuclearball @DrRPalmquist @chidambara09 @DrGrimaldesJ
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Scientists turn blood-cell precursors from an 80-year-old donor into neural stem cells with epigenetic age below 20; 100-day process reveals cellular rejuvenation could aid aging and Alzheimer's research timesofindia.indiatimes.com/…
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Microglia / Lipid Droplets / Lipid Accumulation/ Neuroinflammation Recent studies have shown that lipid metabolic reprogramming regulates microglial polarization and inflammatory function in a spatiotemporally specific manner. The acute phase is characterized primarily by adaptive lipid droplet formation and enhanced fatty acid oxidation, whereas the chronic phase shifts toward pathological lipid droplet accumulation, increased lipid synthesis, and impaired lipophagy. In addition, glial cells in different brain regions vary in their lipid-processing capacity and susceptibility to pathology. Previous reviews have largely focused on individual lipid-related phenomena and have not systematically summarized the spatiotemporal patterns of lipid metabolic reprogramming or potential intervention strategies. Microglial lipid metabolic reprogramming in neuroinflammation ovid.com/jnls/nrronline/full…
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Unraveling the mechanisms of motor neuron degeneration is a critical step toward advancing ALS research and developing targeted treatments. #Healthcare
Behind the Science: In the devastating condition known as amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, the motor neurons degenerate and die. Stanford Medicine’s Aaron Gitler and team are searching for answers. med.stanford.edu/news/insigh…
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Every breath leaves a unique signature in your brain. Speed matters less than shape. Brain recordings from 16 patients showed the rise, fall, and pause of each breath lined up with brain waves tied to mood, focus, and memory. Key findings: • Nose breathing locked the waves in better than mouth breathing • Contour of the breath mattered more than speed • Shallow, rushed mouth breaths can keep the pattern messy (Clark C., brain recordings, 16 patients) Your brain reads the shape of the next breath as it happens. Change the shape and the state can follow. Try this for 60–90 seconds before a stressful task: Exhale 2–3 seconds longer than you inhale, through your nose, with a soft pause. When stress climbs, what’s the first thing your breathing does? Source: Clark C. Every Breath Leaves a Unique Signature in Your Brain. ‌#Neuroscience
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Change doesn’t start with everyone agreeing. It starts with one person willing to promote it.
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The FOXO-aging axis: Epigenetic insights and chromatin mechanisms “… Chromatin context-specific FOXO targeting may improve anti-aging therapy...” sciencedirect.com/science/ar…
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The ACID trial brings valuable clinical evidence to the detection of neoplastic Barrett’s oesophagus, with potential to strengthen endoscopic assessment and support more precise identification of high-risk lesions. #Health
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The hazards and risks are real. 😥 I support these findings. Specially for babies, children, pregnants, and already sick people. Everyone is under risks but there are those more vulnerable. Recognizing the priority: to decreasing and phase out of expossomas and unhealthy bad system. The situations are studied and detected. But better, quicker and efficient solutions are ready and everywhere to be used. Specially technologically. We need a healthy and smart, fair world. However, we could quicker solve these problems, controlling weather and cleaning atmosphere with high technology, while we could change environmental, social and economic habits smoothly. Without conflicts. The money, time and resources to infinitive, unstoppable wars and destruction and genocides 😢could be used to help us to solve problems.
Yesterday @WHO, @WMO, @UNICEF and @UNFPA launched the first-ever set of priority indicators to track how 🥵 extreme #heat affects pregnant women, newborns and children. The evidence is mounting. Heat exposure is linked to a 26% increase in the odds of preterm birth. Babies under one year old lived through 389% more #heatwave days in 2024 than in the 1986–2005 baseline period. About 1.5 billion children worldwide are exposed to heatwaves that are becoming more frequent, longer or more intense. The framework asks countries to monitor preterm births, stillbirths, low birthweight, hypertension in pregnancy, child deaths and #health-facility visits during heat episodes, as well as school attendance. Linking routine health data with #temperature data can help countries pick up early signals and adjust heat-health action plans and #climate adaptation for those least able to escape the heat. who.int/news/item/21-10-2026…
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Brain training apps ALONE do almost nothing for memory. - The trial that actually moved the needle stacked four things at once for two years. In the FINGER trial, at-risk older adults who combined: • Exercise • A brain-focused diet • Cognitive training • Vascular-risk control Improved overall cognition versus advice alone. High adherence to the MIND diet (leafy greens, berries, nuts, whole grains, beans) tracked with slower decline equal to about 7.5 years of age. Exercise raises BDNF and blood flow. The MIND diet feeds the same circuits. Training and practices like dance or tai chi keep the network in use. Unchecked stress shrinks the gains. The cycle we want to avoid: Less movement → poorer sleep and blood flow → foggier thinking → less training and worse food choices. This week, lock one block: 3 brisk cardio sessions + a daily handful of greens and berries. Which lever are you already doing, and which one is still missing? Ref: Ngandu et al., Lancet, 2015; Morris et al., Alzheimers Dement, 2015. #BrainHealth
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Night Owl Eating Habits May Increase Obesity Risk Sleep patterns and meal timing may play a role in preventing obesity and metabolic disease. technologynetworks.com/appli…
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Association between iron deficiency anemia (IDA) & accelerated biological aging: evidence from U.S. & Chinese cohorts Highlights: ▶️ IDA is associated with accelerated biological aging in U.S. and Chinese cohorts. ▶️ Sensitivity analyses confirmed the robustness of the association. ▶️ Addressing IDA may promote healthy aging across diverse populations. sciencedirect.com/science/ar… @Mangan150 @DHPSP @nuclearball @FarmerJeff252 IDA was associated with a 9.11-year higher PhenoAge residual in NHANES ✅️ These findings demonstrated a convergent, cross-national link between IDA and accelerated aging.
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One 20-minute walk nearly DOUBLED gut sound amplitude within 1–2 minutes of stopping. A 2025 Scientific Reports study in healthy adults recorded bowel sounds after an easy walk and found: • Sound amplitude nearly doubled • Digestive sounds filled more of the recording • Peristaltic events rose from ~42 to ~56 per minute( 2025 Scientific Reports) Peristalsis jumped from 42 to 56 events per minute after a single easy walk. The boost fades in minutes, which is why all-day sitting keeps the gut quiet and bloating sticks around. What does this mean for you? Rise up out of your chair (Yes, you can do it) and walk 20 minutes today. When do you notice digestion stall the most - desk days, travel, or evenings? #GutHealth
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A new study in Neurology Open Access suggests that years spent with clinical #obesity in early adulthood may leave a mark on the #brain by midlife. Researchers followed 190 participants from 1985, with MRI scans at an average age of 56.5. Instead of BMI alone, they used the new Lancet Commission definition, which separates obesity with organ and #metabolic dysfunction from preclinical obesity. 70% had been clinically obese at some point, rising from under a third in their twenties to over two-thirds by their mid-forties. Those with clinical obesity had more than twice the median volume of 🧠 white matter hyperintensities, a marker of small vessel damage linked to cognitive decline. The proposed mechanisms include hypertension, diabetes, dyslipidaemia, chronic #inflammation and insulin resistance. doi.org/10.1212/WN9.00000000…
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Replying to @readswithravi
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Hepatitis B control after treatment ends? FDA-approved Hibsago offers that possibility for certain adults without cirrhosis. A 24-week trial result, with serious risks requiring monitoring. fda.gov/news-events/press-an…
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📌 Social Media and References: #INPST #DHPSP #CRBIOTECH and #ExplorDHT 🔗linkedin.com/pulse/social-me…
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