@InnisLab

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 Bordeaux, France
innislab.org
Joined February 2019
  • Tweets375
  • Following341
  • Followers617
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Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/shor…
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Ribosome meeting 2024 (Dec 2 - 4) at The institute of Medical Science, The University of Tokyo, organized by Prof Inada. @inada_lab . inada-lab.ims.u-tokyo.ac.jp/…
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Toutes nos félicitations ! 👏👏👏
Académie des sciences@AcadSciences4 Jun 2024
🔴 EN DIRECT | Cérémonie de réception des nouveaux membres 🌿« STRUCTURE DES RIBOSOMES » Marat YUSUPOV, Directeur de recherche au @CNRS, Institut de génétique et de biologie moléculaire et cellulaire, section de #BiologieMoléculaireCellulaireGénomique 👉 youtube.com/live/ChRvAxZ8WVY
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Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs. Congrats to Anna Loveland and collab. w/@ajplanetearth! nature.com/articles/s41586-0…
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Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in @NatureComms Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. rdcu.be/dHxGL nature.com/articles/s41467-0…
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Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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Innis Lab retweeted
nature
@Nature19 Mar 2024
Researchers have used generative artificial intelligence to help them make completely new antibodies for the first time go.nature.com/3Vio70e

‘A landmark moment’: scientists use AI to design antibodies from scratch

Nature - Modified protein-design tool could make it easier to tackle challenging drug targets — but AI antibodies are still a long way from reaching the clinic.

nature.com
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Our structure of SecM-stalled ribosomes out in ⁦@natcomms⁩. rdcu.be/dBJTZ. Great work by ⁦⁦@felixgersteuer⁩ ⁦@MartinoMorici⁩ and collaborators, with data collected at the ⁦@CssbHamburg⁩ by ⁦@haaris_safdari⁩
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The final version of the most recent paper on the ribosome regulatory TnaC peptide and L-Trp saga is finally out. @gentle_heather @shuramankin Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues - jbc.org/article/S0021-9258%2…
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Jue Wang
@jueseph5 Mar 2024
I wrote a review (with @_JosephWatson @sid_thesci_kid ) on protein design using structure prediction models--i.e. hallucination, inpainting, diffusion. This approach to protein design started as a convenience but has turned out to be surprisingly powerful. cshperspectives.cshlp.org/co…
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Our work on modeling and designing biomolecular assemblies is now in @ScienceMagazine. science.org/doi/10.1126/scie… RFAA Code: github.com/baker-laboratory/… RFdiffusionAA Code: github.com/baker-laboratory/…

Generalized biomolecular modeling and design with RoseTTAFold All-Atom

Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which combines a residu...

science.org
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We are #hiring! In collaboration with #Xavier_Guillory, we seek a talented and motivated postdoctoral researcher in #cryoEM to study membrane #kinase receptors involved in human health and diseases. Please share widely. nature.com/naturecareers/job…

Postdoctoral Position in Structural Biology (M/W) - Bordeaux (Ville), Gironde (FR)

Postdoc position in structural biology to unravel the molecular mechanisms of a receptor kinase associated with human health and diseases.

nature.com
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We reveal the mechanism of bacterial ribosome recycling by HflXr (and HflX). HflXr employs a novel strategy to split the ribosome into subunits that differs from that mediated by EF-G and RRF academic.oup.com/nar/advance…

Mechanistic insights into the alternative ribosome recycling by HflXr

Abstract. During stress conditions such as heat shock and antibiotic exposure, ribosomes stall on messenger RNAs, leading to inhibition of protein synthesi

academic.oup.com
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We are thrilled to share our last #research story @NatureSMB describing how the CNK-HYP scaffolding complex activates RAF kinase by enhancing the KSR:MEK interaction. Great collaborations with the Sicheri lab @SinaiHealth and Therrien lab @IRIC_umontreal rdcu.be/dzjYS
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Cresomycin—a novel synthetic molecule—demonstrates remarkably robust efficacy against multiple, evolutionary divergent forms of antimicrobial resistance, researchers report in Science. Read more: scim.ag/5VZ
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Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: nature.com/articles/s41586-0…
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Innis Lab retweeted
nature
@Nature9 Feb 2024
Nature research paper: Structural basis of ribosomal 30S subunit degradation by RNase R go.nature.com/48badzL
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WilsonLab@WilsonLab27 Feb 2024
Hot of the press...a ribosome story with a twist! We show how the 3' to 5' exonuclease RNase R twists the head of the small 30S subunit by 160° to mediate degradation...rdcu.be/dx4V2
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I am thrilled to share our new paper published in @NatureSMB (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. #Ribosome #mRNA #Science nature.com/articles/s41594-0…
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Innis Lab retweeted
MDMLab@MDMlab_Paris27 Jan 2024
👋DefenseFinder news ! Thinking of how we can better help the community, we provide a new website that includes a wiki on defense systems, a structure database and precomputed DefenseFinder results on >22k genomes. defensefinder.mdmlab.fr Preprint: biorxiv.org/content/10.1101/…
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