@JamesLab9

Leo James' lab at MRC LMB in Cambridge, UK. Host-pathogen interactions, immunity to viruses, TRIM proteins and HIV. Account run by lab members.

 Cambridge, UK
Joined June 2022
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  • Followers951
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Postdoc position in dendritic cell and cross-presentation biology - four days left to apply: mrc.tal.net/vx/mobile-0/appc… Join our team to work on these coolest cells ever! 🥰
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Join the RNA Virus Replication Lab @TheCrick, Europe's largest biomedical institute under 1 roof! 🔴 TWO postdocs (4-6yrs) 🔴 ONE PhD student (4yrs, fully funded, all🌍) We’re looking for bright, motivated people, with the chance to develop & shape projects independently... 1/n
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Researchers at @UKDRI and @MRC_LMB have developed two novel therapies that target tau aggregates in the brain and have shown promise in treating dementia in mice @w_mcewan @JamesLab9 biotechniques.com/proteomics…
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Scientists have developed potential therapies that selectively remove aggregated tau proteins and improve symptoms of neurodegeneration in mice, showing a promising approach for Alzheimer’s disease. More: orlo.uk/N50dm @UKDRI @MRC_LMB

New therapy that destroys tau tangles shows promise for Alzheimer’s

ukri.org
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Replying to @lara_manganaro @DiazGrifferoLab @LubanLab @MickMenager
@donna_mallery is on her way and she will present this new study from our lab: xitter.cf/JamesLab9/status/18359…
Leo James' Lab@JamesLab917 Sep 2024
New study from the lab! Charged rings in the mature HIV capsid protein are required for formation of conical capsids: nature.com/articles/s41467-0…
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Thanks to all authors of that study: @AlexKleinpeter @donna_mallery Nadine Renner, @AnnaAlbecka and Ole Klarhof. Great collaboration between our lab @MRC_LMB and Eric Freed's lab @NIH
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In forced evolution experiments we identified K25A compensating mutations that restore hexamer/pentamer ratio and rescue the shape of the capsid
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Mutations in charged ring residues R18 and K25 lead to formation of circular or tubular capsids in vitro. These mutant viruses are also not infectious in cell culture.
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Right number of capsid protein hexamers and pentamers is required for formation of conical shaped capsids
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New study from the lab! Charged rings in the mature HIV capsid protein are required for formation of conical capsids: nature.com/articles/s41467-0…
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We are looking for a PhD student to continue our exciting work on antiviral immune receptor Trim21! Contact us for any questions and apply here:
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The UK DRI's @w_mcewan & @JamesLab9 (@MRC_LMB) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21. The treatment improved symptoms of neurodegeneration in mice👉buff.ly/47ogpFG
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Thanks Anna!
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New research from @JamesLab9 & colleagues presents 'RING-Bait', which employs an aggregating protein sequence combined with an E3 ubiquitin ligase to specifically degrade tau aggregates while sparing soluble tau (in vitro & in vivo) - impressive new tech! cell.com/cell/fulltext/S0092…
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Amazing new study from the lab on targeted tau degradation technology:
Guido Papa@guidovir_13 Sep 2024
Super excited to share our latest paper on a novel targeted protein degradation technology, now out in @CellCellPress. We introduce RING-Bait technology, an innovative approach to selectively target and degrade intracellular protein aggregates (1/7) cell.com/cell/fulltext/S0092…

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

RING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and selectively degrade pathogenic tau assemblies without generating a specific binder, thereby...

cell.com
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Our recent contribution to work from Gabriella Santoro's lab with @AnnaAlbecka SARS-CoV-2 experiments. Check it out! @SS_Silvia88 @guipap_ @MRC_LMB link.springer.com/article/10…

Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral...

Cellular and Molecular Life Sciences - Organisms respond to proteotoxic-stress by activating the heat-shock response, a cellular defense mechanism regulated by a family of heat-shock factors...

link.springer.com
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Great to be in Leeds for #BUNYA2024 conference! The lab is new to #bunyaviruses so we are sure to learn a lot!
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Congratulations to @MatteoAll and @LabSchafer! And well done to us!
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Replying to @UIowaMicrobio @IowaMed @AlexKleinpeter
Congratulations Alex!
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If you are at #ubfriends2024 don't miss Jakub Luptak's talk about the role of E2 enzymes in TRIM21 driven ubiquitination. Friday at 11.45. New, exciting data from the lab for ubiquitin enthusiasts 😉
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