PhD @likat_rostock, Postdoc @Maes_Group & @RoelfesGroup Now (substitute) professor in organic chemistry @unihh
Hamburg, Germany
Joined May 2017
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For updates of the lab and a small sneak peak of "Longwitz Lab" science, you can now visit the group's website, all about Evolvable Catalysis.
chemie.uni-hamburg.de/instit…
After my first week at @unihh, I am even more excited than before. Lots of interesting chemistry, motivated students, welcoming colleagues and a super-team of supporters, especially in the IT. I can't wait to give my first lectures in "Hörsaal A" next week. 🦥
After more than 4 years abroad, I am going back to Germany to join @unihh as a lecturer of organic chemistry! I will miss Groningen immensely, but now it is time for something new!
A good start to the new year: I was awarded the Postdoc Prize 2024 of the Faculty of Science and Engineering in Groningen! Very happy to receive this award to recognize my achievements in the @RoelfesGroup ! Now, I am looking for a new adventure!
Another boron enzyme from my postdoc, this time with a new protein scaffold. Getting closer and closer to natural enzymes design with our own catalytic dyad! Thanks to all who contributed!
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What would a reaction like this be called? Not really a deracemization, not really a desymmetrization, a double kinetic resolution?
Cool paper using LmrR Boron Enzymes!
Design and Evolution of an Artificial Friedel–Crafts Alkylation Enzyme Featuring an Organoboronic Acid Residue | Journal of the American Chemical Society @TotalSyntheses #FriedelCrafts #Alkylation #Biocatalysis #Organoboronic pubs.acs.org/doi/10.1021/jac…
Lars Longwitz retweeted
Design and Evolution of an Artificial Friedel–Crafts Alkylation Enzyme Featuring an Organoboronic Acid Residue | Journal of the American Chemical Society @TotalSyntheses #FriedelCrafts #Alkylation #Biocatalysis #Organoboronic pubs.acs.org/doi/10.1021/jac…
Hanging out at my poster P4-2 at #biocat2024. Come talk to me about not boring, but boron enzymes.
Presenting my results from the @RoelfesGroup at #nordbioII in Stockholm. A great event so far, lots of interesting biocatalysis.
Lars Longwitz retweeted
This month, an exciting paper has been published in @Nature from @RoelfesGroup, reporting the design of a boronic acid-integrating #enzyme that allows chiral #organocatalytic reactivity not achievable with natural or chemical catalysts. 1/3
Lars Longwitz retweeted
A newly designed enzyme containing boron shows promising catalytic properties currently not found in nature.
It could lead to applications in fields such as medicine or green chemistry.
In @Nature
Led by @RoelfesGroup @univgroningen with @MXESRF
▶️esrf.fr/home/news/general/co…
ALT Close-up view of an active site showing electron density at 1.72 Å resolution of a cyclic boronate-ester intermediate, obtained with X-ray diffraction data collected at the ESRF MASSIF-1 beamline. The observed intermediate supports the unique catalytic role of the boronic acid group in stereoselectively converting alpha-hydroxyketones to oximes. Credits: A. Thunnissen.
Lars Longwitz retweeted
Boron catalysis in a designer enzyme (@Nature): nature.com/articles/s41586-0… (@RoelfesGroup, @LongLarf, @reubenlg).
Lars Longwitz retweeted
Nature research paper: Boron catalysis in a designer enzyme go.nature.com/4bxKuDT
Turning Boron proteins into functional enzymes was the most challenging but rewarding project of my career (so far)! I learned so much during this project and want to thank all collaborators and members of the Roelfes and Mayer group @narf42 for their support!
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Lars Longwitz retweeted
🚨🚨🚨 We are hiring! We are looking for 2⃣ PhD students who want to join us @StratinghInst for awesome research in the field of continuous #enzyme #evolution! Informal questions per DM. Click the link below to apply! #MolecularEvolution
Please RT!
rug.nl/about-ug/work-with-us…
Lars Longwitz retweeted
Publishing sucking the joy out of our profession
teapaw.org/SteveStuWill/status/15…
Lars Longwitz retweeted
Hello phosphine my old friend
I've oxidised you once again
(we finally recorded it, turn the sound on if you dare)
Full length song on youtube: youtube.com/watch?v=C446m6rh…
Xin's paper on epoxide reduction is now online in @ACSCatalysis ! @TheWernerLab @beweries_LIKAT @likat_rostock pubs.acs.org/doi/10.1021/acs…
