Maier Lab @biozentrum @UniBasel -Structure and function of large complexes in metabolism - Twitter account managed by team members and Timm Maier.

Biozentrum, University of Basel, Switzer…
Joined June 2018
The first of a series of new #SerialEM tutorial videos is online - Autocontouring of Grid Squares. Let us know what you think and what topics you would like to see covered in the future! vimeo.com/1009837716
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Congrats to our new SNSF #Ambizione Fellows, Janani Durairaj and Fengjie Wu! @janani_hex will explore variations in viral proteomes & virus evolution. Wu will investigate the dynamics of an important family of cell receptors #GPCR. @UniBasel_en @snsf_ch biozentrum.unibas.ch/news/de…
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Beautiful!
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.1101/…
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How can memories persist in the brain when their properties and supporting biological substrates change over time and experiences? Our latest work newly published in @ScienceMagazine proposes that a balance between memory dynamics and persistence is achieved through the divergent recruitment of multiple memory traces established in parallel upon memory encoding. science.org/doi/10.1126/scie… Welcome to the Multiverse of Memory! A thread. 1/7
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Maier Lab retweeted
Our c-di-GMP sensor story is finally out in @NatureComms: rdcu.be/dHsEh. Including new data demonstrating cdGreen2 as a convenient tool to study DGC and PDE activity in vitro. Great collaboration with @simon_vanvliet and @MaierLab!
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Maier Lab retweeted
Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites! So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomo
In situ cryoET reveals inhibitor-induced perturbations in Pf80S GTPase interactions biorxiv.org/cgi/content/shor… #bioRxiv
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How do only 2 non-visual arrestin isoforms regulate ~800 GPCRs? Our research on CCR5 phosphorylation uncovered a key pXpp phosphomotif crucial for robust arrestin2 recruitment, illuminating intricate details of GPCR desensitization. Now in @MolecularCell doi.org/10.1016/j.molcel.202…
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A team effort with @petrovic_iv and outstanding collaboration with @MaierLab and @arshukla
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This was a spectacular collaboration with @BJ_Greber, and @simakali1. Initially, we thought we would need months of microscope time. @AdrianKoh8 & @cushing_v got all data and first structures within 2 weeks! To make this happen we designed a fast #SBDD workflow with @AdrianKoh8👇
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Interesting to see myself age so much in one click of a slide 😅. Thanks a lot @ribo_rob for dropping by the @biozentrum to share your beautiful mitoribosome research and to tell us about your new company @cryocloud_io. Providing cloud processing for #CryoEM & #TeamTomo!❄️🔬☁️💻
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Maier Lab retweeted
Amy Fraley@aefraley15 Mar 2023
Here we defined the interactions between the novel enzymatic components responsible for the so far unparalleled introduction of a vinyl chloride moiety to a 21-carbon chain during polyketide elongation! Congrats to the team: @MraDll, Max, Roy, Cedric, Groll lab, and @piel_lab!
Online now! Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation dlvr.it/Skq1xR
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Meet biochemist @MariaHondele She has long been fascinated by tiny droplets in the cell, also known as membraneless organelles. In the interview, she talks about her research on this phenomenon and gender equality in science. #WomenInScience 👉 ow.ly/OfEb50MPZcS
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Please RT - we have two tenure-track group leader openings @FMIscience. What we have to offer? -> outstanding students & postdocs, spectacular facilities, a caring faculty, very generous core funding, and a Swiss quality of life. Contact me by email if you require more info.
📢Please RT: We're hiring two tenure-track group leaders, one in Multicellular Systems and one in Genome Regulation/Structural Biology. Apply by March 19 at: bit.ly/MulticellularSystemGL or bit.ly/StructuralBiologyGL #AcademicTwitter
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Apply now for the prestigious and independent #BiozentrumPhDFellowships! Deadline for the winter call is approaching on November 13, 2022. Great science. Unique rotation-based selection of research group and other incentives. bit.ly/2SWAiwF @biozentrum @UniBasel_en
🔥📃Check out our new preprint. Together with @petrovic_iv, we provide insights on a key GPCR phosphomotif and arrestin isoform selectivity based on several #structures, #NMR, #biochemistry, mass spectrometry, and cellular assays. biorxiv.org/content/10.1101/…
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#Antibiotic_resistance is a challenge thus smart solutions are needed! Our collaboration with Kim Lewis lab shows how a computational search had given us a new antibiotic, being highly potent in inhibition of BamA! @NCCR_AntiResist @MajedModaresi @MaierLab nature.com/articles/s41564-0…
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1h 37min 29s representing @biozentrum in my new home
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