Nautilus Biotechnology

We are incredibly proud to announce that our paper demonstrating the large-scale single-molecule analysis of tau proteoforms by Iterative Mapping has been published in Nature Methods! 📰 Press release: globenewswire.com/news-relea… 📘 Paper: nature.com/articles/s41592-0… This paper shows that single-molecule proteomic analysis reveals entirely new facets of biology. Specifically: 🔵 Iterative Mapping enables accessible and scalable proteoform analysis that is not possible on other platforms — Proteoforms are the many distinct molecular forms of proteins that exist in cells. Many can be derived from a single protein and may have vastly different functions depending on their combinations of isoforms, sequence variations, and post-translational modifications. 🔵 Iterative Mapping precisely, sensitively, and accurately quantifies tau proteoforms over a wide dynamic range with high reproducibility (≤5.5% median CV). 🔵 Model systems commonly used in neurodegenerative disease research have distinct tau proteoform profiles. 🔵 In a small cohort, tau proteoform analysis differentiates samples donated by cognitively normal individuals from those donated by people with Alzheimer’s disease and related dementias. 🔵 Preliminary evidence suggests there are ordered pathways underlying the creation of tau proteoforms (they are not created randomly). This implies researchers may be able to prevent the generation of pathological tau proteoforms by disrupting these pathways! Congratulations to everyone at Nautilus and beyond who made this groundbreaking work possible. We’d particularly like to recognize our amazing collaborators including: Researchers from the Regenerative Research Foundation/Neural Stem Cell Institute: Sally Temple, Taylor Bertucci, David Butler, and Steven Lotz Researchers from The Ronald Loeb Center for Alzheimer’s Disease Research Icahn School of Medicine at Mount Sinai: Joel W. Blanchard, Ana Forton-Juarez, Emily Sartori, and Jessica Schwarz Researchers from Genentech: David Arnott, Joanna Lipka, Nikhil Pandya, Lionel Rougé, TJ Wendroff, Don Kirkpatrick, and Alexis Rohou Your expertise, deep understanding of tau and neurodegenerative disease, and innovative spirits made this work a powerful demonstration of the power of Iterative Mapping.