Richard Kevin (@RichardKevinPhD) header
Richard Kevin (@RichardKevinPhD) profile picture

Richard Kevin

@RichardKevinPhD

Scientist; analytical chem and psychopharmacology. Clinical pharmacology and toxicology, St Vincent's Sydney. Opinions = own

 Sydney, Australia
Joined January 2019
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  • Following256
  • Followers322
19Media
Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)Photo by Richard Kevin (@RichardKevinPhD)
Today is my last day at the @Lambert_Usyd and @Sydney_Uni. Very sad to be leaving my many amazing colleagues but excited to take up a Senior Scientist position at @SVHSydney with @osbornidayius and co in their Clinical Pharmacology and Toxicology department!
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I'll be expanding out beyond the wonderful world of cannabinoids and will be working on all manner of things in the therapeutic drug monitoring space. Lots of hplc, mass spec, and clinical trials to come!
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Huge thanks to my wonderful Lambert colleagues @EA_Cairns @AdamAmetovski @eric_sparkes @DuckyMcCartney @MA_BEDOYAPEREZ @JonathonCArnold @iainsmcgregor & many others for their support over the years <3
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Our new study out today: frontiersin.org/articles/10.… In an attempt to characterise what might be contributing to the reported toxicity of some potent synthetic cannabinoids (SCRAs), we did a giant screen to look for off-target effects. The answer …
Frontiers | Off-target pharmacological profiling of synthetic cannabinoid receptor agonists...

Frontiers | Off-target pharmacological profiling of synthetic cannabinoid receptor agonists...

Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and type...

frontiersin.org
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The SCRAs tested hit quite a few GPCRs! But none of these off-target effects were at relevant concentrations or at targets that could explain the toxicity. Instead, AMB-FUBINACA produced CB1-dependent signaling disruption – pointing to on-target rather than off-target toxicity
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So where does this leave us? Many more targets to look at (ion channels?) but for now - and perhaps expectedly - CB1 reigns supreme. Huge thanks to co-authors @EA_Cairns, @StinkyWinky, @BowenLabTweets, @JonathonCArnold, @iainsmcgregor, and @samuel_b_phd
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Richard Kevin retweeted
Eric Sparkes (@eric_sparkes) profile picture
Eric Sparkes@eric_sparkes28 Sep 2022
Our latest paper from @Lambert_Usyd on 4-fluoro and 4-cyanobutyl substituted synthetic cannabinoids is online today! tl;dr: most compounds assayed were moderate to high potency and efficacy CB1 agonists, and should be monitored as emerging NPS 🧪🔍 frontiersin.org/articles/10.…
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📣Free cannabis testing for ACT home-growers 🌿@Lambert_Usyd has launched its flagship CAN-ACT study of home-grown #cannabis in the ACT for medicinal and non-medicinal purposes. ➡️Read more: bit.ly/3dgIwyY #leadershipinaction #cannabismedicinal
Image from Sydney Science (@Sydney_Science)
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Replying to @DuckyMcCartney
@DuckyMcCartney “There is limited evidence to support the assertion that THC produces next-day impairment in driving” #ICADTS #T2022 Very substantial work conducted that was summarised very clearly and concisely @Lambert_Usyd – at Rotterdam, The Netherlands
Image from ICADTSInternational (@IcadtsInternat)
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Checking my email every morning #AcademicTwitter
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🚨 Our new paper on #CBD and driving is out! Doses of up to 1500mg of oral CBD does not impair simulated driving or cognitive performance in humans. 🙌 @DuckyMcCartney, @AnastasiaSuraev, Peter Doohan, @irwin_cg, @RichardKevinPhD, Prof Grunstein, @HoyosCamilla, @iainsmcgregor
Sydney Uni Media (@SydneyUni_Media) profile pictureSydney Uni Media@SydneyUni_Media30 May 2022
Driving under no influence: CBD (cannabidiol) users can safely dose up and drive, a new @Lambert_Usyd study finds. Learn more 👇 bit.ly/3z8F56e #cannabis #CBD @DuckyMcCartney
Taking CBD oil and driving 'safe': study

Taking CBD oil and driving 'safe': study

A world-first study led by Sydney University researchers has found driving under the influence of approved cannabis oil does not impair cognitive abilities

7news.com.au
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Putative SCs MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors pubs.acs.org/doi/10.1021/acs… Cool work reporting more (non)-SCRA as modulators of T-type Ca channels ... plenty of potential in a number of different disease states 1/4
Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T‑Type...

Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T‑Type...

Abstract. Synthetic cannabinoid receptor agonists (SCRAs) are a large and growing class of new psychoactive substances (NPSs). Two recently identified comp

pubs.acs.org
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#THC in blood & saliva are poor indicators of #cannabis-induced impairment... ...found our latest study analysing all available studies. Led by @DuckyMcCartney, w/ @thomasarkell6 @irwin_cg @RichardKevinPhD @iainsmcgregor @BrainMind_Usyd @UsydPsych sydney.edu.au/news-opinion/n…
THC in blood and saliva are poor measures of cannabis impairment

THC in blood and saliva are poor measures of cannabis impairment

Are roadside drug tests for THC in cannabis reliable indicators of driving impairment? New research from the University of Sydney Lambert Initiative suggests not.

sydney.edu.au
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Interested in #NPS? and #harmreduction ? Come and do a PhD with me! (and @AmyKPeacock and @monicabarratt and Rachel Sutherland). You don't even move to Tassie (but you *could*). Ignore the closing date. Please RT! utas.edu.au/our-research/res…
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Image from Richard Kevin (@RichardKevinPhD)
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#icrs2021 day 2. Late breaking research submission - Multiple overnight virtual conference attendance significantly increases snacking amongst academics. We’re (@Lambert_Usyd) on Twitter again, for all your questions 👩‍🔬🧑‍🔬👨‍🔬
Image from Elizabeth Cairns (@EA_Cairns)
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Don't miss out on the Lambert Initiative cannabinoid research showcase at #ICRS2021! Oral presentations: @JonathonCArnold @TheCannabisGuyy @RichardKevinPhD Posters: @samuel_b_phd @EA_Cairns @DuckyMcCartney @JackMarkhamPhD Ayshe Sahinovic & @eric_sparkes new.icrs.co/ICRS2021/ICRS202…
Image from Lambert Initiative (@Lambert_Usyd)
Image from Lambert Initiative (@Lambert_Usyd)
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How to anger chemists:
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📢#Cannabidiol (#CBD) in #cannabis does not impair #driving while #THC produces mild driving impairment that lasts up to 4 hours, shows our landmark study published in @JAMANetwork. @Sydney_Uni X @MaastrichtU #CannabisNews jamanetwork.com/journals/jam…
Cannabidiol and Δ9-Tetrahydrocannabinol Effects on Driving Performance

Cannabidiol and Δ9-Tetrahydrocannabinol Effects on Driving Performance

This crossover randomized clinical trial evaluated driving test performance of healthy young adult volunteers after vaporized consumption of cannabis (Δ9-tetrahydrocannabinol [THC] and cannabidiol...

jamanetwork.com
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