Medicinal Chemist | Postdoctoral Researcher - School of Chemistry, the University of Sydney | @PayneResearch
Joined February 2020
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It's all things adamantane in our (@Lambert_Usyd) latest synthetic cannabinoid work, out now in @ACSChemNeurosci!
We synthesised and evaluated a library of adamantane-derived SCRAs, including fluorinated and deuterated analogues 🧪
🧵
pubs.acs.org/doi/10.1021/acs…
Eric Sparkes retweeted
🎤 presentation by @AxelleTimmerman @ #TIAFT2024:
"Synthesis and functional evaluation of synthetic cannabinoid receptor agonists related to ADB-HEXINACA"
👉 Fri Sep 6, Session 12
👉 Publ. in May @ACSChemNeurosci: pubs.acs.org/doi/10.1021/acs…
👉 🤝 w. @Lambert_Usyd @eric_sparkes
5/11
Support from @Lambert_Usyd, @SydneyChemistry, @Sydney_Science, Sydney Pharmacy School, @syd_health + ANSTO
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Eric Sparkes retweeted
Nice collaborative work (1st paper of @AxelleTimmerman 👏) w. @eric_sparkes & other fantastic @Lambert_Usyd colleagues now out in @ACSChemNeurosci:
Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA
pubs.acs.org/doi/10.1021/acs…
🧵 👇
Latest work from @Lambert_Usyd is online in @ACSChemNeurosci!
In another great collaboration with @christophestove et al., we looked at the recently detected synthetic cannabinoid ADB-HEXINACA and related analogues as emerging NPS🧪🔍
pubs.acs.org/doi/10.1021/acs…
More SCRA work from @Lambert_Usyd out now in @rsc_medchem!
We looked at a series of proteinogenic amino acid-derived SCRAs related to MPP-5F-PICA, MMB-5F-PICA, and MDMB-5F-PICA, investigating the role of chirality in CB1 and CB2 receptor activation.
pubs.rsc.org/en/content/arti…
Amazing team includes @JackMarkhamPhD, Rochelle Boyd, @TheCannabisGuyy, Humayra Zaman, Rebecca Gordon, Katelyn Walker, Chianna Dane (@KassiouGroup), @RichardKevinPhD, @MariJSantiago, Dai Hibbs, @samuel_b_phd, @AdamAmetovski, and @EA_Cairns
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Thanks to @Lambert_Usyd, @SydneyChemistry, @Sydney_Science, @BrainMind_Usyd, @MQMedicalSchool, and Sydney Pharmacy School for making this work possible.
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Amazing team includes @AxelleTimmerman @JackMarkhamPhD Rochelle Boyd, Rebecca Gordon, Katelyn Walker, @RichardKevinPhD, Dai Hibbs, @samuel_b_phd, @EA_Cairns, @christophestove, and @AdamAmetovski ✨✨
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Thanks to @Lambert_Usyd @SydneyChemistry @Sydney_Science @ugent and Sydney Pharmacy School for the ongoing support.
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Assessment of βarrestin 2 recruitment was performed by @AxelleTimmerman and @christophestove, with many compounds acting as potent and efficacious agonists at both receptors. Remarkably, many compounds displayed efficacies far above that of CP55,940 at CB1.
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In silico evaluation was used to rationalise some structure-activity relationships observed with Induced fit docking performed by @JackMarkhamPhD and Dai Hibbs
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Latest work from @Lambert_Usyd is online in @ACSChemNeurosci!
In another great collaboration with @christophestove et al., we looked at the recently detected synthetic cannabinoid ADB-HEXINACA and related analogues as emerging NPS🧪🔍
pubs.acs.org/doi/10.1021/acs…
Membrane potential assay work was performed by Rochelle Boyd and @EA_Cairns, and revealed most compounds were potent and efficacious agonists of CB1 and CB2.
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