@RothbartLab

Professor @VAInstitute. Chromatin biochemistry, cancer epigenetics, functional proteomics.

 Grand Rapids, MI
rothbartlab.vai.org/
Joined November 2018
  • Tweets261
  • Following255
  • Followers619
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Scott Rothbart retweeted
Yael David@Yael_David__17 Jul 2025
Big day for the David lab! 🎉 Our @MolecularCell paper is out today- huge congrats to first authors @IfeAkano & Jake Hebert for leading this beautiful study uncovering SMARCA3 as a novel H3 E3 ligase that shapes heterochromatin regulation in colorectal cancer 🤩
Molecular Cell@MolecularCell17 Jul 2025
Online Now: The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer dlvr.it/TLz0Lw
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Replying to @Yael_David__ @KarunaMDPhD @RichardKoche @SimoneSidoli @themazelab @qinggaochem @YangXiao_TPCB @TPCB_NYC @WeillCornellGS @MSKCancerCenter @WeillCornell
Wonderful to see this out! Congrats again to Ife, Jake, Yael and team!
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Replying to @PVertino
Wonderful news, congratulations!!
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A person’s lifetime risk for #cancer may begin before they are even born, reports a paradigm-shifting study by Van Andel Institute scientists published in @NatureCancer. @PospisilikJ @Bi0lilla vai.org/cancer-risk-developm…
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Replying to @FuksLab @CELL
Congratulations, Francois! Exciting to see this story out.
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Thrilled to share the results @Cancer_Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. cell.com/cancer-cell/fulltex…

Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets

Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five...

cell.com
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Scott Rothbart retweeted
Lluis Morey@lluismorey11 Dec 2024
We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
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Congratulations to Van Andel Institute’s Dr. Peter Jones, VAI and @HopkinsKimmel's Dr. Stephen Baylin, and @HopkinsMedicine's Dr. Andrew Feinberg, who will receive the Harvey Prize for their groundbreaking work in cancer epigenetics! Read more: vai.org/harvey-prize
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This preprint is now published with some key additions guided by an excellent review process @NAR_Open. Also grateful to our collaborators for helping progress this one across the finish line! @suscla1 @qianthefirst @Yael_David__ @zhouwanding and others! academic.oup.com/nar/advance…

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu

academic.oup.com
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Replying to @MolecularCell
Thank you, Chhabi! Hope all is going well.
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Replying to @Yael_David__ @MolecularCell
Thanks, Yael! And same to you for your new exosome story.
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Replying to @KJArmache @MolecularCell
Thanks, KJ!
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Online Now: DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states dlvr.it/TGZ732
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Replying to @MolecularCell
We are excited to share this work that reveals a novel function for UHRF1 in the regulation of H3K9me3 and demonstrates a conservation of mechanism for H3ub-H3K9me3 crosstalk in mammals! Also a new approach for targeting SUV39H1/2 to enhance DNMT inhibitor efficacy.
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Scott Rothbart retweeted
Ayush Raman@aayushraman4 Dec 2024
Congratulations to the authors @RothbartLab, shows the role of UHRF1 in the redistribution of H3K9me3 following DNA hypomethylation, a lingering question in the field and may have implications for the field of aging. cell.com/molecular-cell/full…
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Two new papers from the lab to end the year! Will be posting about them both at the new place in the coming weeks. @rothbartlab.bsky.social Come join us - it’s great! #SciCommBackAgain
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Replying to @helin_kristian @helink
Also made the move. It’s becoming reminiscent of the good ‘old’ days of ScienceTwitter over there. Come join us! @rothbartlab.bsky.social
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Time to move. See you all on Bluesky: @helink.bsky.social Let's work on getting our respective institutions and our colleagues to move as well. There is an exponential increase in members on Bluesky!! theguardian.com/media/2024/n…
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Congratulations!!
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If you are interested in a faculty position in the heart of metabolism, at one of strongest and most supportive institutes focused on metabolism, epigenetics, neurodegeneration and more, VAI is recruiting at all levels! vai.wd1.myworkdayjobs.com/en…
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