@ShechnerLab

The Shechner lab in UW Pharmacology. We study Noncoding RNAs and cellular architecture. He/His/Him. All comments are my own. @ShechnerLab.bsky.social

 Seattle, WA
shechnerlab.org
Joined September 2018
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  • Followers2.8K
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A friendly reminder that the application deadline for the UW Pharmacology PhD program is coming up on December 1st. Apply today! pharmacology.uw.edu/graduate…

Admissions - UW Pharmacology

pharmacology.uw.edu
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Exciting new work from the @touchyourbrain, Soden, and Zweifel labs, deciphering the regulation of dopamine patterns by ion channels. Congrats to all authors on the awesome work!! science.org/doi/full/10.1126…

Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape...

Ion channels in midbrain dopamine neurons are critical for patterning action potential firing, dopamine release, and learning.

science.org
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Calling all chemical biologists: Mark your calendars Sept 7-12, 2024 for the @EMBO Chemical biology conference at @embl in Heidelberg. Should be the must-attend chembio conference of the year! embl.org/about/info/course-a…

Chemical biology 2024

embl.org
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Our new work with @sokrypton @UWproteindesign core labs, DiMaio lab. We introduce AfCycDesign, where we adapt the #AlphaFold network for cyclic peptide structure prediction and design. biorxiv.org/content/10.1101/…

Cyclic peptide structure prediction and design using AlphaFold

Deep learning networks offer considerable opportunities for accurate structure prediction and design of biomolecules. While cyclic peptides have gained significant traction as a therapeutic modality,...

biorxiv.org
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Check out our first preprint of the 1.55 Å cryo-EM structure of the bacterial translating ribosome!! An awesome collaboration between our group at @UVA with the @SimoneMattei19 group at the Imaging Centre at @EMBLHeidelberg and the Atkins group at @UCC biorxiv.org/content/10.1101/…
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SheqLab retweeted
Junyue
@junyue_cao1 Feb 2023
Excited to share our latest preprint from Cao Lab - PerturbSci-Kinetics, led by brilliant @xu_zxu! The technique captures single-cell transcriptome, nascent RNA, and sgRNA identity in pooled CRISPR screens, for identifying key regulators of RNA kinetics. tinyurl.com/2nyuz49a
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I am excited to present this work led by Frederick Rehfeld (not on Twitter). We performed genome-wide CRISPR screens to identify host factors required for programmed ribosomal frameshifting by SARS-CoV-2. 1/4 cell.com/cell-reports/fullte…

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed...

Programmed ribosomal frameshifting is essential for SARS-CoV-2 replication. Through genome-wide CRISPR screening, Rehfeld et al. find a requirement for ribosome recycling factors in efficient...

cell.com
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Fantastic new review from @StellaLab11, in @NeuroCellPress, describing our current understanding of THC's and CBD's mechanisms of action and therapeutic potential. A great resource for those new to the field. Congrats! authors.elsevier.com/a/1gPf2…
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Correlation Vs. Causation
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SheqLab retweeted
jobRxiv
@jobRxiv17 Aug 2020
#ScienceJobs: Postdoctoral position in Proteomics with @lab_ong University of Washington; Pharmacology, Seattle, USA jobrxiv.org/job/university-o… #proteomics
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Joe Biden.
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Best thing I’ve heard, Nancy Pelosi states: “...we must listen to science, science, science. To those who say I’m praying for an answer, I say science is the answer to your prayers”. Amazing.
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Remarkable RNA engineering: by randomizing and evolving an amino-acid sensing domain of #Tbox #riboswitch, the Suga Lab creates a new ribozyme that aminoacylates specific tRNAs, just like their protein brethren & sistren. Congrats Hiro, Satoshi, &Naohiro! nature.com/articles/s41589-0…
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If you're looking for something to read while stuck at home, the accepted version of our chemical transcription roadblocking paper is now online @jbiolchem! jbc.org/content/early/2020/0…
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I support the current bailout - its needed For reference though, here is how the annual NIH budget (in red), meant to fund ALL of biomedical research, compares to the current $1T bailout proposal (in blue) Not only can we afford to invest more in science, we can't afford not to
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The World Health Organization has announced that dogs cannot contract Covid-19. Dogs previously held in quarantine can now be released. To be clear, WHO let the dogs out.
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Automated continuous evolution of proteins in vivo biorxiv.org/cgi/content/shor… #bioRxiv
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Checkout our paper on how lncRNA regulate SWI/SNF function at promoters-enhancers nature.com/articles/s41467-0… Great work by @ElenaGrossi8 !

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Nature Communications - SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the...

nature.com
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A structural view Of histone mRNA 3' processing #ChromatinHaiku science.sciencemag.org/conte…
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Extremely excited to announce sci-Plex, described in a new paper out today science.sciencemag.org/conte…! Joint work with @JShendure lab, led by a crack team: @SRsrivatsan, @joselmcfaline, and @vram142. With sci-Plex, we can profile expression in single cells from thousands of samples.
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