@TheFischerLab
 Memphis, TN
stjude.org/fischer
Joined September 2019
  • Tweets42
  • Following109
  • Followers235
3Media
Interested in adding a splash of water to your ligand discovery campaign? Check out our latest article: nature.com/articles/s41592-0…
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A GUI that seamlessly integrates FLEXR electron density based multi-conformer model building into Coot1's modeling and validation tools. journals.iucr.org/j/issues/2…

FLEXR GUI: a graphical user interface for multi-conformer modeling of proteins

This article describes a graphical user interface (GUI) for the multi-conformer modeling program FLEXR, designed as a plugin within Coot 1. At the click of a button, the GUI allows seamless integra...

journals.iucr.org
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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Exemplifies the power of collaboration at @StJudeResearch by CBT Chemistry Centers, @KlcoLab and @TheFischerLab funded by @AlexsLemonade. nature.com/articles/s41467-0…
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The opus magnum of our PhD student Fatemeh, now @KymeraTx, is out in @BloodJournal in collaboration with the @CMullighan lab: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. ashpublications.org/blood/ar…

The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic...

Key Points. SJ6986 is an orally available GSPT1/2-degrading molecular glue that potently suppresses lymphoblastic leukemia cell proliferation in vivo.CRISP

ashpublications.org
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We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medicine! @StJudeResearch bit.ly/BC2M_2023

Bringing Chemistry to Medicine Symposium

The Bringing Chemistry to Medicine Symposium (Oct. 1-2, 2026) features thought leaders at the interface of chemical and biomedical sciences, working in areas spanning therapeutic regulation of...

stjude.org
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Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed a tool to help, which garnered new insights into the chaperone protein HSP90—an essential target in cancer. Read about their work. bit.ly/3LMhQVf
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FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597983230…
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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B doi.org/10.7554/eLife.84632

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

Many small-molecule fragments bind differently to the allosteric protein PTP1B in room-temperature instead of cryogenic crystal structures, which may be relevant for structure-based drug design.

elifesciences.org
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Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks in protein cavities. pubs.acs.org/doi/10.1021/acs…

Accounting for Solvation Correlation Effects on the Thermodynamics of Water Networks in Protein...

Abstract. Macromolecular recognition and ligand binding are at the core of biological function and drug discovery efforts. Water molecules play a significa

pubs.acs.org
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New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotspots on #HSP90, an important target in cancer. bit.ly/3SRxpwt @ACSBioMed
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Thrilled to see @TheFischerLab's latest work on how "Water Networks Repopulate Protein-Ligand Interfaces With Temperature" out in @angew_chem. onlinelibrary.wiley.com/doi/…

Water Networks Repopulate Protein–Ligand Interfaces with Temperature

Cryo-cooled water molecules block protein motions that impact protein–ligand interactions. Paired cryo and room-temperature comparisons of ligand-bound Hsp90α structures show that water networks and...

onlinelibrary.wiley.com
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Excited to see our collaborative work on the “Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia” appear as a Plenary Paper in @BloodJournal with @CMullighan and #stjuderesearch CBT Chemistry Centers. authors.elsevier.com/a/1eDN%…
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What's under your mask? Happy #Movember2021! Support here: movember.com/m/mogul123?mc=1 Join here: movember.com/t/memstache?mc=…

Morcus Fischer's Mo Space

Morcus's Motivation: Raise awareness, money and eyebrows

us.movember.com
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TheFischerLab retweeted
Behnam Nabet@behnamnabet11 Oct 2021
The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs…
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Phenyl-Glutarimides improve PROTAC stability. Another great collaboration with the CBT ChemistryCenters @StJudeResearch and @TheFischerLab (and many others) just appeared in @angew_chem. onlinelibrary.wiley.com/doi/…

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

IMiD-based PROTACs rapidly hydrolyze in commonly utilized cell media, which significantly affects their cell efficacy. We designed novel BET PROTACs based on phenyl glutarimide (PG) and showed that...

onlinelibrary.wiley.com
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Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :)
CBT Friends and Family@AnsariLab29 Sep 2021
Replying to @TheFischerLab
@TheFischerLab has an available #postdocposition in computational #structuralbiology for a very cool project on #ligand discovery bit.ly/FischerPDCSB @blkwomencompbio @StJudeResearch #compbio #LXChemBio
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💥Enhanced sampling strikes again: we used aMD to see a buried apolar cavity open up to solvent, feeding this thermodynamic info to DOCK3.7 we saw some really cool new chemistry that also showed up in the beautiful crystals from Isha Singh 🎉🎉 #compchem #cadd @PNASNews
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Expanding the chemical toolbox for bromodomain PHD finger transcription factor BPTF in a fun whirlwind collaboration with @fewill26 and @TheFischerLab. pubs.acs.org/doi/10.1021/acs…

New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor...

Abstract. The nucleosome remodeling factor (NURF) alters chromatin accessibility through interactions with its largest subunit,the bromodomain PHD finger t

pubs.acs.org
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Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article pubs.rsc.org/en/content/arti…

Temperature artifacts in protein structures bias ligand-binding predictions†

X-ray crystallography is the gold standard to resolve conformational ensembles that are significant for protein function, ligand discovery, and computation

pubs.rsc.org
Chemistry World@ChemistryWorld7 Sep 2021
New research suggests that sampling only at cryogenic temperatures could be making things murky for structural data, leading to irritating cryo-artifacts chemistryworld.com/news/over…

Overreliance on cryocooled protein structures may compromise ...

Scientists behind first of its kind study encourage more researchers to analyse protein structures at room temperature

chemistryworld.com
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🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front cover 😍 Read it here ➡️ Temperature artifacts in protein structures bias ligand-binding predictions 🔗 ow.ly/htjA50G2PSZ 📍 @UCIrvine | @StJudeResearch
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