Tomislav Čaval (@TomislavCaval) profile picture

Tomislav Čaval

@TomislavCaval

Postdoc at @Stanford w/ @CarolynBertozzi. Native MS Glycoproteomics. Table tennis enthusiast.

Joined November 2009
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Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)Photo by Tomislav Čaval (@TomislavCaval)
Wait a minute pt.2 they submitted their work 6 months before yours.
Image from Tomislav Čaval (@TomislavCaval)
Kathy Y. Wei, Ph.D. (@KathyYWei1) profile pictureKathy Y. Wei, Ph.D.@KathyYWei1Oct 24
Wait a minute - we already did that 😛 pubs.acs.org/asbcd6/article-…
An Artificial Intelligence Model for Translating Natural Language into Functional De Novo Proteins

An Artificial Intelligence Model for Translating Natural Language into Functional De Novo Proteins

Abstract. Traditional protein design is fundamentally constrained by known sequences and folds. To break free from these limitations, we introduce a new al

pubs.acs.org
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Happy to share BSRA interview. Hoping to do the #Glycotime justice. Full of untapped potentials. bioanalysis-zone.com/videos/…
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This is borderline criminal #glycotime . How did this get through?
Signal Transduction and Targeted Therapy (STTT) (@sigtrans_sttt) profile pictureSignal Transduction and Targeted Therapy (STTT)
@sigtrans_sttt6 Aug 2024
He, M., Zhou, X. & Wang, X. Glycosylation: mechanisms, biological functions and clinical implications. Sig Transduct Target Ther 9, 194 (2024). doi.org/10.1038/s41392-024-0… #glycosylation
Image from Signal Transduction and Targeted Therapy (STTT) (@sigtrans_sttt)
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Hmm…
Image from Tomislav Čaval (@TomislavCaval)
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When you use byonic Protein FDR cut off and report glycopeptides you end up with 50 000+ glycopeptides across a 100 samples, with <100 glycopeptides detected in 25 or more samples. Looks like 70+% glycopeptide FDR
bioRxiv Cancer Bio (@biorxiv_cancer) profile picturebioRxiv Cancer Bio@biorxiv_cancer1 Nov 2024
The Whole Proteome, Phosphoproteome, and Glycoproteome Landscape of Pan-Cancer Cell Lines Profiled by Mass Spectrometry and Reverse ... biorxiv.org/cgi/content/shor… #biorxiv_cancer
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🏆🌟We’re thrilled to announce that this year’s Bioanalysis Rising Star Award winner is Tomislav Caval!🌟🏆 Find out more about Tomislav’s research into unraveling O-glycosylation patterns with mucinases and mass spectrometry >>> hubs.ly/Q02V6XGz0 @WatersCorp
Image from Bioanalysis Zone (@BioanalysisZone)
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Looking forward to talking all things O-glyco!
Bioanalysis Zone (@BioanalysisZone) profile pictureBioanalysis Zone
@BioanalysisZone18 Oct 2024
Meet our Bioanalysis Zone Rising Star Award winner, Tomislav Caval! In this webinar, Caval will present his experience with leveraging mass spectrometry and mucinase enzymes to unravel O-glycosylation patterns >>> hubs.ly/Q02SYVSk0
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Tomislav Čaval retweeted
Hans Wandall (@HansWandall) profile picture
Hans Wandall@HansWandall14 Oct 2024
Copenhagen Center for Glycocalyx is looking for talented Postdocs to work in cell biology, glycobiology, genetic engineering, and mass spectrometry. Do not hesitate to reach out! Find details at: lnkd.in/eyhWJQgv and lnkd.in/eKjmiCuCare
Image from Hans Wandall (@HansWandall)
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#Glycotime I am hiring a Co-op (June -December). If you are interested in developing MS based O-glycoproteomics workflows, Native and CDMS please apply below! careers.regeneron.com/en/job… via @regeneron
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Last few days to vote for Bioanalysis rising star award. I would appreciate any support for my nomination: bioanalysis-zone.com/videos/…
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@chrashwood @labs_mann could I bother you to help with visibility of the above? Unfortunately my tweets get silenced due to seldom X usage.
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Amazing to meet up everyone after so long. Superbly organised by @hecklab. Grateful for the opportunity to represent #glycotime on stage.
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And another #glycotime work I played a part in is now out. See our review on the potential of glycoproteomics in cancer biomarker discovery jhoonline.biomedcentral.com/…
Decoding the glycoproteome: a new frontier for biomarker discovery in cancer

Decoding the glycoproteome: a new frontier for biomarker discovery in cancer

Journal of Hematology & Oncology - Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating...

link.springer.com
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Happy to share our #glycotime story is out! We tackled proteins carrying the elusive PolyLacNAc, also found out not all anion-exchange based enrichment methods are made equal. Special shout out to Gege and Flavio for seeing this through the finish line! pubs.acs.org/doi/10.1021/acs…
Mass Spectrometry Analysis of Glycopeptides Enriched by Anion Exchange-Mediated Methods Reveals...

Mass Spectrometry Analysis of Glycopeptides Enriched by Anion Exchange-Mediated Methods Reveals...

Abstract. Glycosylation is a key modulator of the functional state of proteins. Recent developments in large-scale analysis of intact glycopeptides have en

pubs.acs.org
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Happy to see #glycotime story I played a small part in both on the cover and a most read article in @LSAjournal
Image from Tomislav Čaval (@TomislavCaval)
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Check out the March issue of Life Science Alliance: we're on the cover! A claw machine is used to artistically illustrate the selectivity of an anti-PD-1 antibody for fucosylated variants (red pyramids) of PD-1. Congrats to the team on this achievement! ow.ly/PZY850QK11C
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

Monoclonal antibodies targeting the immune checkpoint PD-1 have provided significant clinical benefit across a number of solid tumors, with differences in efficacy and toxicity profiles possibly...

life-science-alliance.org
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Variable #PD1 #Glycosylation Modulates Activity of #ImmuneCheckpointInhibitors. New data from @InterVennBioSci life-science-alliance.org/co…
Image from LifeScienceAlliance (@LSAjournal)
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Great showcase of things hiding in plain sight unraveled by native MS!
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Tomislav Čaval retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggoner1 Nov 2023
Anti-Siglec-7 monoclonal or Siglec-7 bispecific NK cell engager demonstrate potent targeted Ovarian cancer therapeutic activity in vitro and in vivo @ScienceAdvances science.org/doi/full/10.1126…
Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity...

Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity...

Anti-Siglec-7 MAb or Siglec-7 bispecific NK cell engager demonstrate potent targeted OC therapeutic activity in vitro and in vivo.

science.org
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Expect nothing less from superstars!
Johannes Florian Hevler (@JHevler) profile pictureJohannes Florian Hevler@JHevler13 Oct 2023
@Hecklab and I worked on a cross-linking mass-spec centric review on probing mitochondrial complexes in situ. We hope this is useful for everyone interested in the structural organization of the mitochondrial proteome.
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