Ernst Wolvetang retweeted
University of Queensland researchers have found a way to reverse a cellular process triggered by COVID-19 that contributes to premature ageing of the brain 🧠
Read more: brnw.ch/21wEE6B
@AIBNatUQ @JulioAguado_PhD @Wolvejong
Ernst Wolvetang retweeted
Very good summary of these provocative findings that may help treat #LongCovid in the future
nature.com/articles/s43587-0… @NatureAging
Ernst Wolvetang retweeted
A study in @NatureAging shows that SARS-CoV-2 induces senescence in human brain organoids and in the brains of infected mice and humans and demonstrates the therapeutic potential of senolytic therapy in protection against COVID-19-induced brain aging. go.nature.com/3QEcsVu
ALT This is figure 5, which shows senolytics clear virus-induced senescence in specific neuronal subtypes.
Ernst Wolvetang retweeted
Online now! Aguado et al., show SARS-CoV-2 induces senescence in human brain organoids and in the brains of COVID-19 infected mice and human; demonstrating the potential of senolytic therapy in protection against COVID-19-induced brain aging. doi.org/10.1038/s43587-023-0…
Ernst Wolvetang retweeted
‼️We found that #senolytic therapy alleviates human brain #aging and mitigates #SARSCoV2 neurological adverse effects.
Grateful to all our collaborators and to share this with you all! 🧠🔬
#covid #Senescence #Organoids
Find out more here @NatureAging 👇
nature.com/articles/s43587-0…
Ernst Wolvetang retweeted
‼️Have a look at our latest research on the role of #senolytic therapies in mitigating #senescence-driven human brain #aging and the neuropathological sequelae caused by SARS-CoV-2 infection.
biorxiv.org/content/10.1101/…
@UQ_News @harvardmed @UniFreiburg @AIBNatUQ
Ernst Wolvetang retweeted
How do you study the #brain at the cell level, when you can't get inside it? You build your own brain in a dish of course! Listen to AIBN's Prof Ernst Wolvetang @Wolvejong discus how he uses this cutting-edge research to understand how brains are made ow.ly/y1Py50HV3tp
Ernst Wolvetang retweeted
How do you study the #brain when you can't get inside to see it in action? You build one in a dish! @AIBNatUQ's Professor Ernst Wolvetang describes how he's using cutting-edge research to understand how brains are made. @Wolvejong
bit.ly/34WcTXc
#AGreyMatter #Podcast
Ernst Wolvetang retweeted
In 2nd instalment of this week's #MeetTheTeam, this video provides a great insight to the amazing work undertaken by Prof @Wolvejong & his team at @AIBNatUQ & shows how this genius can help @ourmoonsmission to #CureSPG56 💉🧬🌙 #MoonShot #JoinOurMission
youtube.com/watch?v=nmV-C3f2…
An important mission that needs your support! Join and retweet!
Prior to official launch on #GivingTuesday, we kickstarted #OurMoonsMission with #TallulahsArmy, leading the charge, starting over 150 mini Facebook fundraisers.
With their help, Genetic Cures for Kids has already raised over $120k to fund vital @AIBNatUQ & @GRIDD_GU research 🙏
Ernst Wolvetang retweeted
Using #BrainOrganoids 🧠 , researchers find that increased cGAS and STING activity is an important contributor to chronic inflammation and premature senescence in the central nervous system of ataxia-telangiectasia.
bit.ly/38LWDXp
Crispr a/i in hIPSC derived brain organoids shows anti-senescence effect of Klotho. Nice one Mo! So proud of this team.
@AIBNatUQ researchers studying ageing in tiny ‘live’ models of the human brain called #organoids have found that increasing levels of the ‘anti-ageing’ protein klotho reduced the deterioration in brain cells associated with #age and #dementia.
aibn.uq.edu.au/article/2021/…
Ernst Wolvetang retweeted
#AIBN's @JulioAguado_PhD from #WolvetangLab shows innate immunity drives #senescence in astrocytes of brain organoids from Ataxia Telangiectasia (A-T) patients. @Wolvejong @AIBNatUQ @UQ_News @AgingCell #UQResearch
doi.org/10.1111/acel.13468
Discovering that a childhood ataxia can also be a progeroid syndrome was unexpected. So proud of this team !
Happy to share one of my postdoc stories just out in
@AgingCell
We show that #senescent astrocytes upregulate the #SASP in a cGAS-STING-dependant manner and promote accelerated #aging in brain #organoids of #ataxia-telangiectasia.
doi.org/10.1111/acel.13468…
@AIBNatUQ
Discovering that a childhood ataxia brain progeroid condition disguised as a childhood ataxia (and vice versa) .
Happy to share one of my postdoc stories just out in
@AgingCell
We show that #senescent astrocytes upregulate the #SASP in a cGAS-STING-dependant manner and promote accelerated #aging in brain #organoids of #ataxia-telangiectasia.
doi.org/10.1111/acel.13468…
@AIBNatUQ
Ernst Wolvetang retweeted
Exciting PhD position available in the Wolvetang lab at @AIBNatUQ to further develop and apply novel CRISPR genome manipulation technologies. DM @Wolvejong or email [email protected].
Ernst Wolvetang retweeted
A country “determined to commit economic suicide but unable even to agree on how to kill itself”, led by “a ship of fools” unwilling to “compromise with one another and with reality”.
Deluded by our “popular, lowbrow, chauvinistic, rightwing press”.
bit.ly/2CYaAC4
We are proud to help finishing Massimo’s mission and use our stem cell models to both understand these leukodystrophies AND identify and test novel treatments. – at Brisbane, Queensland
We are thrilled to share the announcement of $3 million of Federal Government funding for Massimo’s Mission. A touching tribute to honour Massimo’s legacy and support pioneering research to finish the mission he started. bit.ly/2Gkrejh #finishthemission #missionmassimo
Judith Campisi explaining cell non-autonomous (paracrine) effects of senescent cells at ABAC3 ageing conference at UQ.
