@_ConnorStead

Bioinformatician | Proteomics

 United Kingdom
bit.ly/Google_scholar-connorstead
Joined September 2012
  • Tweets48
  • Following910
  • Followers379
Dynamic time course of muscle proteome adaptation to programmed resistance training in rats journals.physiology.org/doi/…

Dynamic time course of muscle proteome adaptation to programmed resistance training in rats |...

Resistance training promotes muscle protein accretion and myofiber hypertrophy, driven by dynamic processes of protein synthesis and degradation. Muscle adaptations to ongoing resistance training...

journals.physiology.org
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We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue. The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles: biorxiv.org/content/10.1101/… 🧵
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Very pleased to see our chapter on Muscle Proteome Dynamics published in The Skeletal Muscle: Plasticity, Degeneration and Epigenetics - A collection of brilliant chapters from leading researchers on muscle biology. link.springer.com/chapter/10…

Muscle Proteome Dynamics

Skeletal muscle demonstrates remarkable malleability and can alter in metabolic and contractile properties in response to changes in environmental stimuli, in particular contractile work. The muscle...

link.springer.com
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Science is not a zero sum game. The more we collaborate, the more we combine data, the greater the likelihood that together we'll discover new things.
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Adaptive time course of the skeletal muscle proteome during programmed resistance training in rats biorxiv.org/content/10.1101/… #biorxiv_physio

Adaptive time course of the skeletal muscle proteome during programmed resistance training in rats

Resistance training (RT) promotes muscle protein accretion and myofiber hypertrophy, driven by dynamic processes of protein synthesis and degradation. While molecular studies have focused on acute...

biorxiv.org
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Exercise-Specific Adaptations in Human Skeletal Muscle: Molecular Mechanisms of Making Muscles Fit and Mighty sciencedirect.com/science/ar…
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Thank you @kenkhallenbeck for nicely summarizing our @molcellprot article in @ASBMB. Sibling study reveals mechanism for genetic disease asbmb.org/asbmb-today/scienc… @LJMUSportSci @LJMU @LJMUImpact @ChildrensNatl @FSHDSociety @MDUK_News @FSHDUKgroup @FSHDEurope @FSHD_Leiden #FSHD

Sibling study reveals mechanism for genetic disease

Using proteomics experiments, researchers found that old proteins pile up in the mitochondria of people with a form of adult-onset muscular dystrophy.

asbmb.org
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- People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training - Cool new article by @ExercProteomics, @mackinprof & Co. analyticalsciencejournals.on…

People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise...

This pilot experiment examines if a loss in muscle proteostasis occurs in people with obesity and whether endurance exercise positively influences either the abundance profile or turnover rate of...

analyticalsciencejournals.onlinelibrary.wiley.com
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People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training pubmed.ncbi.nlm.nih.gov/3796… Obesity and insulin resistance are associated with compromised muscle proteostasis, which may be partially restored by endurance exercise.

People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise...

This pilot experiment examines if a loss in muscle proteostasis occurs in people with obesity and whether endurance exercise positively influences either the abundance profile or turnover rate of...

pubmed.ncbi.nlm.nih.gov
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Amazing day yesterday at the Healthy Muscle Ageing Conference #hmac2023 Well done @ExercProteomics @jlAreta @pugh_jamie @KelsieOJohnson Amazing speakers @mackinprof @LeighBreen @csbd7 @OllyWitard @CazStaunton @mette_contact So much great info and inspiration for future research – at Liverpool, England
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Connor Stead retweeted
Paige Cole@paigecole4415 Sep 2023
Results for the Poster competition 🏆 🥇Stuart Hesketh 🥈Marie Korzepa 🥉 Hanan Sharkh Huge congratulations to everyone who presented a poster today 🥳 @ARThealthyaging @LJMU @LJMUSportSci @ProrizonTech @BBSRC @BiochemSoc @physoc
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News on our recent work on #FSHD here musculardystrophyuk.org/news… Well done @YNishimura87 @_ConnorStead and a big thank you to @MDUK_News @LJMUSportSci and our collaborators Yi-Wen Chen and Adam Bittel @ChildrensNatl
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Connor Stead retweeted
Colleen Deane@csbd726 Jul 2023
Interested in muscle ageing? Join us at the Healthy Muscle Aging Conference in Liverpool on September 15th Registration is open now and you can be in with a chance to win FREE REGISTRATION Full details: tinyurl.com/3hz6t2ap #HMAC2023
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Healthy Muscle Ageing Conference @LJMU ljmu.ac.uk/conferences/Healt… The first Healthy Muscle Ageing Conference (HMAC), here at Liverpool John Moores University (LJMU).
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IN PRESS THP: - RT ⬆️ strength, hypertrophy & physical function VS no exercise - Load, volume, frequency, exercise order impact strength gains - Volume and contraction type impact hypertrophy Nice work team! @mackinprof @MACleod_JC sciencedirect.com/science/ar…
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SAVE THE DATE - Healthy Muscle Ageing Conference 15 September 2023 - more details coming soon From one of our pump-priming projects led by @ExercProteomics #TranslationalStudies
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Connor Stead retweeted
José L Areta@jlAreta6 Apr 2023
Our latest study on the effects of training following a low carbohydrate high-fat diet on skeletal muscle epigenetic regulation is now out in @AJPEndoMetab. (w/@DrAdamSharples @pete_gorski @dcturner93, @JamesyMorton) journals.physiology.org/doi/… Results are not what we expected!🧵 1

Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise | American Journal...

We aimed to investigate the human skeletal muscle (SkM) DNA methylome after exercise in low-carbohydrate (CHO) energy-balance (with high-fat) conditions compared with exercise in low-CHO energy-def...

journals.physiology.org
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Connor Stead retweeted
bioRxiv@biorxivpreprint20 Mar 2023
Muscle of obese insulin-resistant humans exhibits losses in proteostasis and attenuated proteome dynamics that are improved by exercise training. biorxiv.org/cgi/content/shor… #bioRxiv
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We are recruiting participants to study how protein supplements with/without Urolithin A impact muscle health during single-leg immobilization. Please share and contact me (see image) if interested!
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Connor Stead retweeted
Jen@JennyBarrett1128 Feb 2023
Today was the launch of our Liverpool Muscle Healthy Aging study! @ExercProteomics @richjfoster @pugh_jamie @KelsieOJohnson @Richie_Kirwan
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