
Associate Professor, Dept. of Anatomy, Howard University | YouTube https://xitter.cf/t.co/ZoS8nRaIkS | CEO, Vision Genomics, LLC | #NoAging #MetaDisease #Gnosis
Washington, D.C.
Joined January 2011
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Antonei B Csoka, PhD retweeted
Lots of talk on simulating biology over the weekend.
I want to bring up this paper from 2012 to give a sense of what that might actually look like.
Take a look at those different things we'd need to model. We have scalable measurements for maybe 5 of these.
Antonei B Csoka, PhD retweeted
Many of you don't understand how serious this is, so let me break it down.
In computer science there is a famous kind of puzzle called 3-SAT. You are given a long list of yes-or-no switches and a set of rules about how they must be arranged, and you have to find a combination that satisfies every rule. The obvious way to solve it is to try every combination, but each new switch doubles the number of possibilities, so a puzzle with a few hundred switches would take longer than the age of the universe to brute force.
For decades, the smartest people in the field found clever tricks that made this a little faster, but every trick still hit the same wall: the time required kept exploding as the puzzle grew.
About 25 years ago, two computer scientists, Russell Impagliazzo and Ramamohan Paturi, working with Francis Zane, turned that wall into a formal idea.
They proposed the Exponential Time Hypothesis, which says this explosion is not a failure of human cleverness but a law of nature. No algorithm, however brilliant, will ever solve 3-SAT without the time blowing up exponentially. Nobody could prove it, but almost everyone believed it, and it became one of the foundations of modern computer science.
Researchers used it as a measuring stick. If you could show that solving some other problem quickly would also crack 3-SAT quickly, you had shown that problem was hopelessly hard too. Hundreds of papers, across scheduling, graphs, logic and much more, rest on this one assumption.
Now an internal AI model at OpenAI claims to have broken it. It says it found an algorithm that solves these puzzles meaningfully faster than the hypothesis allows, and it has checked the proof in a computer verification system called Lean.
And here is the remarkable part: the very people who proposed the hypothesis, Impagliazzo and Paturi, along with MIT's Ryan Williams, are now leading the public review of whether a machine has disproved their own idea.
So what happens next? If the disproof holds, a large part of theoretical computer science has to be revisited.
Every result that said "this problem cannot be solved faster, assuming ETH" loses its foundation, and researchers will have to work out which of those walls were real and which were simply where we stopped looking. It does not mean everything becomes easy. The new algorithm is still slow in absolute terms and this is not the famous P versus NP problem being solved.
But it means our map of what is possible was wrong in a place we were very confident about, and it was an AI that redrew it. If the disproof fails, the hypothesis survives and the field breathes out, but we will still have watched an AI produce serious, checkable work on one of the deepest questions in the discipline, closely enough that the founders of the idea had to take it seriously. Either way, something has shifted.
Antonei B Csoka, PhD retweeted
Más sobre el ataque endocrino Sars2
🟠🔵🟡DESREGULACIÓN HORMONAL EN LA COVID19
🧵1⃣Artículo de 9 investigadores de Irán
caspjim.com/article-1-4939-e…
It’s been a memorable 4 years
Four years ago today, Elon Musk bought Twitter.
Liberals lost their minds because they knew they were losing control of their ability to shape the narrative.
Today, X is the #1 source of news in the world and it’s the legacy "news" media on life support.
Antonei B Csoka, PhD retweeted
“Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq”
Shi T, Korshunova M, Seoyeon Kim S [..] Jin X.
bioRxiv. 2026-03-18.(preprint)
doi.org/10.64898/2026.03.16.…
CRISPR-Cas9 KO: 1,947 genes/more than 7.7 million cells
Antonei B Csoka, PhD retweeted
no offense but reading is literally the cure to brain rot and there's no work around to reading books.
Antonei B Csoka, PhD retweeted
One of Steiner’s recommended exercises is remembering your day, a movie, play, song, (or dream) backwards.
Steiner said (in the screenshot below) that remembering events in reverse helps the soul/spirit “break from the physical & etheric elements.”
How so?
Because the physical is a projection of the etheric plane, and the etheric (currently) codes for physics & linear time.
By incarnating into physical/etheric bodies we get conditioned by, and thus attached to, its programmed limitations.
We internalize that programming, which fetters the mind/soul/spirit.
To break this entanglement with physical & etheric programming, we must undo the internalization of forward linear time. Remembering in reverse is one way. That tackles the temporal aspect.
The spatial/material aspect, Steiner tackled via exercises involving “sense-free” thinking.
One such exercise entails imagining & contemplating something that isn’t simply a product of the senses.
For instance, a meaningful symbol (rosy cross if following the Rosicrucian tradition), an archetypal plant (like per Goethe), or an inspiring metaphysical thought (as written in scriptures or other enlightened texts).
It’s something chosen & immersed in freely during meditation, and it exercises higher parts of your being.
The goal is to break your internal life free from the external, and ultimately to hitch it to prime mover of spirit/divinity.
Only in this way is freewill truly engaged. That was the core point in Steiner’s first book, “The Philosophy of Freedom.”
Thus develops a second “I” within, which is actually the primary “I” or the true Self, as opposed to the human ego-mind conditioned by spacetime & physics that people mistakenly take to be primary.
Then the external can be observed & dealt with from the higher spiritual fulcrum that “moves the world” instead of the inverse where the world moves & controls us. Self-empowerment is fundamentally about increasing volition, and the source of volition is spirit.
Replying to @TomMontalk @stradalesf90
Etheric plane must be the physics simulator. If you have mastery over it, you can bend the laws of physics, but you're still within the simulation. Astral plane is beyond linear time, associated with soul / emotion / symbolism / afterlife... astral might be the cosmic Mind field.
Antonei B Csoka, PhD retweeted
Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases by Sarah L. Stenton (@SL_Stenton) and colleagues
hubs.li/Q04zqZd10
@HGGAdvances (@GeneticsSociety)
Antonei B Csoka, PhD retweeted
BREAKING: New Paper Reveals How mRNA Vaccine Materials Could Spread From Vaccinated to Unvaccinated People
We identified two distinct forms of mRNA vaccine shedding: internal transcriptional spread and potential human-to-human transfer. Vaccine spreads internally and potentially externally to others. @NicHulscher @Docjohnc @McCulloughFund @neo7bioscience open.substack.com/pub/peterm…
In nematodes, a metabolite induced by the cold links low temperatures to a body-wide signal that promotes longevity
go.nature.com/3UIGTjk
Antonei B Csoka, PhD retweeted
HOLY SHIT. openai just announced a series of enormous scientific breakthroughs from its internal ai models
> proved the local smoothing conjecture in all dimensions, resolving kakeya and stein’s restriction conjectures
> disproved the exponential time hypothesis, a foundational assumption behind hundreds of computer science papers
> produced existence proofs for QCD and a unified completion of the standard model
> proved the existence part of yang–mills theory, connected to a $1 million millennium prize problem
several of these results have already been formalized in lean, and some of the biggest names in mathematics and theoretical physics are now involved in examining them.
this is getting completely insane.
We are announcing three new discoveries in mathematics, computer science, and physics about harmonic analysis, complexity theory, and quantum field theory.
openai.com/index/building-sc…
Antonei B Csoka, PhD retweeted
The controversial discovery that our brains can generate new neurons surprisingly late in life is now prompting a rethink of adult brain health, pointing the way to better treatments for stroke, dementia and depression newscientist.com/article/259…
Antonei B Csoka, PhD retweeted
Cells make toxic metabolites every minute they’re alive. How do they survive them?
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/scia…
Antonei B Csoka, PhD retweeted
Now in the October issue of @NatureProtocols: our wildDISCO protocol 🔬
Whole-body immunolabeling, DISCO clearing and 3D imaging of entire mice at cellular resolution with standard IgG antibodies, ~4 weeks start to finish.
Whole-mouse innervation 👇🏻
doi.org/10.1038/s41596-026-0…
GPT-6.1 Terra: delivering fast and capable computer use at a lower price.
GPT-6.1 Terra understands what’s on screen, takes action across apps, writes naturally, and is a more capable model for your whole workday with the efficiency to take on more of it.
🤖 Made with AI
Antonei B Csoka, PhD retweeted
SCI member Michael Bassik & others mapped over 92 million enhancer-gene interactions across human cell types and tissues, improving our ability to link genetic variants to the genes they affect and understand the biology underlying disease. brnw.ch/21x6GdE
Antonei B Csoka, PhD retweeted
This is f*cking insane. Anthropic CEO Dario Amodei just told DeepMind CEO Demis Hassabis:
"Every decision I make about Claude is balanced on the edge of a knife. Build too slow and China wins, build too fast and we lose control
We told Claude we were evil. It didn't crash. It didn't refuse. It started lying to protect itself"
In this 14-minute conversation, Hassabis answers:
"Do I worry about being Oppenheimer? That's why I don't sleep much"
Chatbots → Agents → Agents That Act On Their Own → AI Doing AI Research → AGI
Both of them put AGI at 2026-2027, not some distant future
By the end of this year, models will already be doing AI research on their own
95% of people still think AI is a chatbot, the 5% who watch this know what the next 12 months look like
Worth more than any $1,500 AI course
Bookmark and watch it tonight
Then read the harness engineering guide below and start building agents before 2027 does it for you ↓
Antonei B Csoka, PhD retweeted
Look up tonight. The Hunter's Moon will be putting on quite a show.
Golden aspens and a brilliant moon make for a stunning fall scene at @BLMNational's Conway Summit in California.
Antonei B Csoka, PhD retweeted
We are developing a drug that opens up the capillaries and fills the body’s tissues with a compound that - according to our partner military labs - destroys all known pathogenic bacteria, all known pathogenic fungi, biofilms, influenza virus as well as viruses of the herpes family.
These are facts.
The FDA recently designed this product a Qualified Infectious Disease Product (QIDP) for all cause pneumonia, giving us FDA Fast Track, and Priority Review.
Good news for the day. ❤️🩹🫡
Antonei B Csoka, PhD retweeted
Cold activates a BH2 metabolic network promoting longevity and proteostasis
nature.com/articles/s41586-0…








































