Most of Medicine Makes Sense in the Light of Aging, Individualised Aging Diagnostics and Therapeutics For All
Cambridge, UK
Joined December 2015
- Tweets206
- Following186
- Followers309
- Likes50
agecurve retweeted
have a new tagline: Most of Medicine Makes Sense in the Light of Aging cc @agecurve
agecurve retweeted
the local #Cambridge @agecurve Team has now 4 people, just the amount needed to cover the necessary bases and deliver the next milestones! #geroscience #longevity #aging #genomics #singlecell #celltrees #somaticevolution #scRNAseq #deeplearning #AI
agecurve retweeted
Issac started this week at @agecurve as Senior Computational Biologist and Translational Geroscientist Extraordinaire :)
Thrilled to announce my May start at @agecurve! The challenge: integrating RWD with expanding atlases, crafting unified manifolds across multiomic landscapes. 👉 Unlocking insights into somatic state evolution and aging. #ComputationalBiology #DigitalTwins #SingleCell 🌐 1/3
agecurve retweeted
📣 We're delighted to welcome AgeCurve as an Affiliated Company.
Find more on @agecurve here: agecurve.co.uk 👀
Happy to announce that AgeCurve has joined the affiliate companies network of @TheMilnerInst representing some of the most innovative biomedical companies in the #Cambridge ecosystem milner.cam.ac.uk/affiliate-c…
we are really looking forward to @IssacEGoh joining us in the #Cambridge office
Thrilled to announce my May start at @agecurve! The challenge: integrating RWD with expanding atlases, crafting unified manifolds across multiomic landscapes. 👉 Unlocking insights into somatic state evolution and aging. #ComputationalBiology #DigitalTwins #SingleCell 🌐 1/3
agecurve retweeted
happy to announce that @IssacEGoh is joining @agecurve as a senior computational biologist full time from May, Issac, currently at @HaniffaLab and a visiting scientist at @sangerinstitute, is a multitalented individual who aced the technical interview and he'll be joining us at #Cambridge @ideaSpaceCity office, please see thread below on this beautiful #SingleCell @humancellatlas @ScienceMagazine study dissecting the role of human yolk sac in haematopoiesis where Isaac was joint first author teapaw.org/HaniffaLab/statu…
New in @Science! 🎊
Our #Developmental @humancellatlas study (bit.ly/yolk_sac) uses #SingleCell profiling to map the human yolk sac, pivotal for embryonic survival & first prenatal blood and immune cells. Data-portal: bit.ly/YSportal 👈
[1/12] 🎥 by @megumi4952
agecurve retweeted
shook hands with 2 extremely qualified and trusted people this week as they will start working for @agecurve in 2024, the future of the most affordable, scalable and bimodal Cell Tree methodology looks bright, Cell Tree Age is only the start biorxiv.org/content/10.1101/…
agecurve retweeted
happy to announce that AgeCurve has secured a quarter of a million GBP seed investment without any Nobel Prize laureate/Big-Name PI added to our Board as our science speaks for itself ;) we have a smarter and cheaper way to measure scalable single cell somatic mutation burden across the life sciences market space via Cell Tree Rings, look out for job openings agecurve.co.uk/
agecurve retweeted
Cell Tree Rings manuscript v2.0 is on @biorxivpreprint
major updates, fixing issues & 3 new positive results:
1. External Validation of our Cell Tree Age Model on public scRNA-seq data from @humancellatlas/@czi
2. Exploratory associations between predicted Cell Tree Ages & clinical biomarkers, for some markers cell tree age is a better predictor than chronological age
3. additional phylogenetic evidence: Cell Tree Age Model with Maximum Likelihood tree inference too biorxiv.org/content/10.1101/…
Let me introduce Cell Tree Rings (CTR): the shape of somatic evolution as a human aging timer, we at AgeCurve believe CTR can serve as a core component for combined aging clocks to mitigate current uncertainty in assessment of geroprotective trials 1/17 biorxiv.org/content/10.1101/…
agecurve retweeted
AgeCurve Ltd uses Cell tree rings and somatic mutation-calculate biological age @LongevityTech @TinkingGumbel @agecurve @attilacsordas
Those running geroprotective trials, academic researchers, clinical trials could use Cell tree rings #BiologicalAge
liveforever.club/article/age…
agecurve retweeted
Using somatic evolution as a human #aging timer
As a core component of combined aging clocks, #CellTreeRings could mitigate current uncertainty in assessment of geroprotective trials.
@agecurve @petrsramekbench
longevity.technology/news/us…
agecurve retweeted
fascinating history behind #plasmapheresis
1913 concept
1950-51 prototyping 4 plasma donation
1959 first immune disorder app
1963-68 current setup using 1878 creamer separation tech
2020 “neutral” age blood exchange - TPE 4 #aging ncbi.nlm.nih.gov/pmc/article…
en.wikipedia.org/wiki/Plasma…
agecurve retweeted
this is what the most important head of @emblebi so far had to say on #aging research, keep it up: 'If you really want to know about human ageing, you need access to human data.' here's the @NatureAging study referred nature.com/articles/s43587-0…
Access to human genetic and medical data is revolutionising our understanding of age-related diseases. Researchers from EMBL-EBI and @ucl have used data from @uk_biobank to define how a patient’s condition relates to their age.
ebi.ac.uk/about/news/announc…
agecurve retweeted
Human aging is unequally distributed. While some become frail in their 60s, others run marathons into their 90s. But when do disparities in biological aging begin to matter?
doi.org/10.1038/s43587-021-0……
Preprint:medrxiv.org/cgi/content/shor……
@NeurogenDuke @NatureAging @DukePsychNeuro
We measured the pace of biological aging by quantifying the decline of 19 biomarkers across 2 decades from age 26 to 45 in the Dunedin birth cohort. Building on previous work, we find enormous variation in the rate of biological aging in midlife. doi.org/10.1073/pnas.1506264…
agecurve retweeted
Great to hear from David Weinkove @dweinkove, Karl Morten @Ox_wrh and Attila Csordas @agecurve in the @UK_SPINE Geroscience lunchtime Webinar looking at #drugdevelopment acceleration. #UKSPINE2021 @UK_SPINE
ALT Behind the scenes of #UKSPINE2021 lunchtime webinar
agecurve retweeted
N&V: Bérénice Benayoun @BBParis1984 highlights a recent Resource published in @NatureAging from the @maxin_artomov lab that provides detailed multi-omics information about how human monocytes change during aging. Read it here: nature.com/articles/s43587-0…
agecurve retweeted
#Proteostasis as a therapeutic target in age-related #neurodegeneration...
A new study identifies #proteostasis decline as a hallmark of human cellular #aging #proteinopathies.
#longevity #cellular
@TechnionLive @attilacsordas
longevity.technology/proteos…
agecurve retweeted
#Collagen #crosslinking is a major pathology during #aging, however, it is difficult to assess. @AnneHaefke shows how to use the "Tail Tendon Break Time for the Assessment of #Aging and Longitudinal #Healthspan in #Mice". @bioprotocolbyte #ewaldlab @eth bio-protocol.org/e3833