Making high-utility medicines @proxbio. Past: @Alnylam, @scrippsresearch, @InzenTx, @ycombinator W20 Fortitudine vincimus. Tradbio delenda est.

Joined April 2019
General Proximity (@proxbio) is coming out of stealth. General Proximity is developing a new class of medicines that we believe has the potential to decrease global disease burden, transform human health, and extend lifespan more than any other current therapeutic modality. 🧵
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happy tuesday
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excited to welcome David to @proxbio to co-lead our Functional Genomics team! unreal stuff coming from this team... :)
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🚨 [Token][ization] Paper Alert 🚨 Tokenization is a wildly understudied area of language modeling despite it having effects across all of NLP. Over the past ~8 months, 32 (!) tokenizer researchers put together the most comprehensive survey of the field. Check it out!
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🏮Announcing the Lantern Summit in Shanghai🏮 In 2025, more new medicines launched first in China than anywhere else on Earth. That has never happened before. Drug development has two simultaneous accelerators: •⁠ ⁠AI is collapsing design (weeks instead of years). •⁠ ⁠China is collapsing development (physical iteration speed). Here is why that matters, and what Western biotech is missing: 🧵
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We're hiring. Think: Sr partner at a venture incubator, but the outputs are Focused Research Organizations Form the thesis, find the founders, build the boards, launch the org AI resilience: bioresilience, cyber-physical systems, epistemic infrastructure, compute governance
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training yourself to feel things like this on a gut (heh) level instead of just believing them intellectually is one of the greatest skills you can learn it makes action natural and frees up willpower for more important things
The most useful thing I've learned about food mastery is that eating bad things is never, ever worth it. You never feel good after. Only regret. Once you fully internalize this, you can simulate the experience and then muster the power to overcome the primal desire.
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This is one of the most famous paintings in America, and most people have no idea what they are actually looking at... The painting is Christina's World, made by Andrew Wyeth in 1948, and the woman was real: her name was Anna Christina Olson, Wyeth's neighbour in Cushing, Maine. Since childhood a degenerative condition had slowly taken the strength from her legs, until walking was no longer possible. She refused a wheelchair, and for her entire adult life she chose to drag herself across the ground with her arms instead, going wherever she wanted to go under her own power. Wyeth saw her one afternoon from an upstairs window, alone in that vast field, crawling slowly toward the house on the hill. He said the painting was an attempt to do justice to her extraordinary conquest of a life which most people would consider hopeless. Her world, he said, was limited physically but by no means spiritually. That is what turns this painting from a portrait of frailty into one of the most triumphant images ever made... Look at it long enough and it stops being about what her body took from her, and becomes about what she would not stop doing anyway. The field is enormous and she is small and the house is far away, and still she goes, because the alternative, to be carried, to give up, to let the distance win, was something she simply would not accept. There is one more thing: Christina loved this painting. Pink was her favorite color, and Wyeth had placed her exactly where she most wanted to be, out in the open, in her own field, under her own sky. Late in her life, when she could no longer even crawl out to that field, she said something that holds the whole meaning of art inside it: "Andy put me where he knew I wanted to be. Now that I can’t be there anymore, all I do is think of that picture, and I’m there."
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Apply here for our Computational Research Scientist position and work with us @AnthropicAI on making fundamental biological discoveries: – at Manhattan, NY
Another job posting for a computational role in our research group focused on making fundamental discoveries in biology: job-boards.greenhouse.io/ant…
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Not sure who needs this but stop wasting your time trying to convince VCs who fundamentally don't understand your biz. You're not going to win every room. And you don't need to. The more technically ambitious the company, fewer investors will have the framework to underwrite it. That's literally where alpha comes from. Consensus is what shows up after everyone else has already made money. Find the few investors who have conviction before it's obvious. Quit trying to drag everyone else across the finish line. Move the f*ck on.
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Across 5000+ founder meetings, the rarest success trait we saw was pathological determination (<1% of founders). These individuals have a borderline-delusional ability to run through any wall and don’t have an off-switch. It’s not easy to screen for and most investors don’t ask the right questions to uncover it. We have 12 proxy signals that we use to measure determination, such as a desperate desire to prove someone/something wrong, multiple previous failed businesses, early-life adversity and irrational optimism when most others would quit. Our findings showed that founders with a high determination index were much more likely to build bigger companies, even if it took them longer. Determination wasn’t correlated with confidence or charisma; the most determined founders were more introverted and did not light up rooms. Most investors incorrectly ignore the power of persistence.
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😀
25 young, smart, and gifted 10x entrepreneurs who have the potential, together with Elon and Palmer, to lay the foundation for the next 250 years of the USA: Aaron Slodov @aphysicist Armand Cognetta @armandcognetta Augustus Doricko @ADoricko Ben Nowack @bennbuilds Casey Handmer @CJHandmer Chris Power @2112Power Delian Asparouhov @zebulgar & Will Bruey @WillBruey Edward Mehr @EdwardMehr Ethan Loosbrock @ELoosbrock Fil Aronshtein @FilArons Guillaume Verdon @GillVerd Ian Brooke @ianbrooke Isaiah Taylor @isaiah_p_taylor Jai Malik @jaimalik James Coutre @JimCoutre Jim Belosic @jimbelosic Matt Gialich @MattGialich Matt Loszak @MattLoszak & Yasir Arafat @yasir_fission Sam D'Amico @sdamico Sam Zeloof @szeloof Scott Nolan @ScottNolan Tyler Bernstein @tybernstein Zach Dell @ZachBDell & Justin Lopas @JLopas Zack Eakin Zane Hengsperger @zanehengsperger
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Just telling people they slept poorly led to impaired cognitive function. Telling them they slept fine preserved it.
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completely agree. biotech has been harder to disrupt than tech for various structural reasons, and that's allowed many bloated, bureaucratic, slow, and overly conservative companies to survive the market is coming for them though, and patients will benefit from this
Replying to @brian_armstrong
I'd also say most biotechs are not as well run (from what I can tell). And they could learn a lot from the software industry. i.e. techbio > biotech And the 1-2 orders of magnitude complexity will get tackled with AI, not human brains. i.e. bio-naive > bio-insight driven
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sufficiently advanced small molecules are indistinguishable from magic
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996 is a mimetic infohazard if you don't use it for something you love so much burnout from people grinding just for the sake of grinding do things that matter
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induced proximity is the future of medicine and we've barely scratched the surface of what's possible with it... there is simply no other modality that combines the versatility of small molecules with the power of much more complex next-gen therapeutics
One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore
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🚀🚀🚀
Welcome to Team GP Andreas Maderna!
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