Energetically compromised #pwME and patient advocate (when able) • Research scientist by trade • Interested in how we live • Open-minded but generally sceptical
United Kingdom
Joined July 2011
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get ready for the most nauseating performance of disagreement with trump by JD vance from today until the presidential primary
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Democrats will win big tonight then give their own voters the middle finger by appointing Hakeem Jeffries as Speaker and Chuck Schumer as Leader, and nothing will fundamentally change. This is how the duopoly works, which is why we need to topple the system.
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Olympians demand better ME funding after sprinter Beth Dobbin speaks out thetimes.com/uk/healthcare/a…
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Gas, not renewables, is the biggest driver of UK electricity bills. Pricier gas explains nearly 90% of the rise in household bills since 2020.
Gas plants still set the power price most of the time. Cutting gas is the surest way to cut bills.
janrosenow.substack.com/p/re…
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Only in America do people see a story about a dude who’s being exploited by his employer and think “let me make that corporation exponentially richer”
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A staggering snapshot of modern scientific publishing: Scientific Reports scaling toward ~48,000 articles in 2025 alone. Let that sink in:
• ~130 published manuscripts every 24 hours
• Millions generated in article processing charges (APCs)
• An unprecedented volume spike that even indexing pipelines like PubMed are struggling to keep pace with At this scale, the traditional concept of peer review is stretched beyond credibility. No editorial board on earth can maintain genuine scientific oversight across 50,000 heterogeneous papers a year.
🎯☕📊📑#ScientificPublishing #ResearchCulture #MegaJournals #HigherEducation #PeerReview #OpenAccess #ScholarlyPublishing
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It really is *mad* that the global financial crisis (and the Cameron / Osborne response to the aftermath) is just utterly absent from any discussions about why we are where we are. We've never recovered
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.@MorePerfectUS spoke to Trump voters in rural Florida. They are begging for help. They voted for Trump but they are now open to voting for a Democrat who can guarantee universal health insurance.
This 28-year-old man has testicular cancer and needs chemotherapy immediately to survive. His doctor gave him three months to live unless he can get treatment immediately. The treatment costs $50k+. He has no health insurance. He's hoping for Medicaid to come through but in Florida most adults without kids don't qualify.
"Everybody having health insurance will be absolutely amazing"
He says he's now open to voting for politicians who are fighting for universal health insurance.
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This is another problem with trials that have no mechanism, where all you can measure is symptoms.
Does titration matter? Or is this just cope? It's probably just cope, but we can't know for sure.
If it wasn't titration, there's an endless list of variables someone could cite to explain why the trial failed: they didn't test the right dose, the right subgroup, the right timing. Etc. etc.
If there were an actual mechanism, they could check whether the drug was hitting its target. But since there's no mechanism, they can't.
So the trial gives us an answer: LDN, the way it's usually prescribed, doesn't beat placebo. What it can't give us is closure.
I've already seen people pre-empt the inevitable failure of the tirzepatide trial in a similar way, saying that they're testing too high of a dose. So when it fails, people already have a built in excuse to ignore the results.
This is not scientific thinking. This is religious thinking. No observation can disprove the things people want to believe. But since almost no one in this space is doing real science, it's what youd expect.
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Elon Musk has spent more money on American elections in the last two years than George Soros has in his entire life.
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Hugely consequential election results in Brazil and Serbia last night. With the mid-terms also looking disastrous for Trump the global Fascist wave might be ebbing. And with youth uprisings exploding across Europe room is opening for a left response to 2027's accelerating crises.
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What do all those calling for ‘benefit cuts’ think happens to benefit payments? They get spent- every penny! On food, on energy etc etc As our economy seems to depend on how much shopping we do, depriving people of spending power is daft isn’t it? Quite apart from condemning people to harshly impoverished standards of living.
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Vivek Ramaswamy turned the desperation of Alzheimer’s patients and their families into a financial opportunity, buying a drug that had already failed four clinical trials for $5 MILLION, taking it public at a multibillion-dollar valuation, and personally cashing out nearly $40 MILLION while his biotech empire raised billions from investors.
Then the drug failed again, and its stock collapsed 70%. Families were hoping for a medical breakthrough. Investors lost fortunes. Ramaswamy walked away with millions.
This wasn’t the miracle investors were sold. It was exploitation dressed up as innovation.
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The UK being a serviced based economy makes it more vulnerable to AI than most.
The government needs to urgently wake up and immediately formulate a strategy to manage the incoming impact.
It’s unbelievable to me this hardly features in political discourse.
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You see why they urgently need to slash welfare.
Barclays cutting 5,000 jobs as bank increases its use of AI bbc.in/4zNvcXC
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Remarkable things are happening on Science4ME.
As part of the process developed by @weandmecfs with Science4ME, researchers who have advanced to the second round of the WE&ME Projects Call are voluntarily presenting their proposals for discussion with forum members.
They’re testing their ideas against the knowledge, experience and questions of scientifically minded patients.
If you’re scientifically minded yourself, have expertise in research, methodology or a relevant field, or bring an informed patient perspective, consider joining. Your experience and questions could help strengthen ME/CFS research.
The forum is sometimes criticised as “negative” or “pedantic”. That’s hilarious, because people who question assumptions and scrutinise details are exactly those you should want to test your ideas with if your goal is scientific progress. It’s not a panacea, but it should certainly be part of the process.