
GI Med Onc | @ConquerCancerFd #ASCO21 Merit Award. @GWSMHS @GWCancer @UTHimres @McgovernMed alum đŽđąđťđŞ
Miami Beach, FL
Joined April 2021
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Aron Simkins, MD retweeted
If the KKK marched down Fifth Avenue and burned a cross in Washington Square Park, I would vociferously protest. If one of those marchers were elected to Congress, I would call it an abomination and a desecration of our nationâs highest values.
That is why I cannot remain silent when an anti-American bigot like Darializa Avila Chevalier has just received the Democratic congressional nomination.
All Americans should oppose bigotry and intolerance wherever we see them, regardless of our politics or affiliations.
Aron Simkins, MD retweeted
#ASCO26
This one is special.
This is the hottest paper of 2026 and potentially in the history of pancreatic cancer.
Letâs dive in.
RASolute 302: Daraxonrasib vs investigatorâs choice chemotherapy in previously treated metastatic pancreatic cancer
Abstract LBA5 (soon!)
Presentation: May 31, 2026, 3:21-3:33 PM CDT
For decades, pancreatic cancer has been where good ideas go to die.
We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains.
But the central driver of PDAC has always been sitting there in plain sight:
RAS.
More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it.
Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS.
And in RASolute 302, it delivered.
Quick hits:
đ Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigatorâs choice chemotherapy
đ§Ź RAS G12 population
91.8% of patients had RAS G12 mutations
đ OS in RAS G12 population
13.2 vs 6.6 months
HR 0.40
P<0.001
đ OS in overall population
13.2 vs 6.7 months
HR 0.40
P<0.001
đ PFS in RAS G12 population
7.3 vs 3.5 months
HR 0.45
P<0.001
đ PFS in overall population
7.2 vs 3.6 months
HR 0.49
P<0.001
đĽ 12-month OS
Overall population: 53.2% vs 17.3%
â ď¸ Toxicity matters, but this was not just more efficacy for more toxicity
Grade âĽ3 AEs: 61.8% vs 69.6%
TRAEs leading to discontinuation: 1.2% vs 11.2%
This is the kind of survival curve we almost never get to see in pancreatic cancer.
This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial.
The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone.
RAS is here, and it couldnât have come sooner.
nejm.org/doi/full/10.1056/NEâŚ
@TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO
@NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc
Aron Simkins, MD retweeted
Waiting for two abstracts to be presented the whole @AACR #AACR26, this is one of them
Just presented, #Daraxonrasib in #mKRAS #PDAC by @EileenMOReilly
#Monotherapy in the #FirstLine
38 pts
ORR 47%
Time on tto 7.7m
PFS immature
Ongoing Phase III 303 (Dara vs GemNab+/-Dara)
Let's take steps together at PurpleStride! secure.pancan.org/site/TR;jsâŚ
Aron Simkins, MD retweeted
Mamdani Clarifies That His Wife Only Celebrates Terrorism In Her Capacity As A Private Citizen buff.ly/FBGKO2a
Aron Simkins, MD retweeted
You would think the current mayor of NYC @NYCMayor would put out a statement like this one and we wouldnât have to rely on the previous mayor.
The chants heard yesterday in the heart of the Jewish community in Kew Gardens, Queens, in support of Hamas were vile and deliberate acts of intimidation meant to terrorize our Jewish community.
NYC and state elected officials must condemn this immediately and unequivocally. Anything less is a failure of leadership.
Silence leads to action. We must say it loud and clear: HAMAS AND THEIR SUPPORTERS ARE NOT WELCOME HERE.
Aron Simkins, MD retweeted
HERIZON-GEA-01 phs-3: Zanidatamab + CTx +/- Tislelizumab in 1st line Her2+ locally advanced unresectable or mG/GEJ adenocarcinoma
#ASCOGI26
đ ORR: 70 vs 69 vs 65%
đ mPFS: 12.4 vs 12.4 vs 8.1 mo
đ mOS: 26.4 vs 24.4 vs 19.2 mo
đClinical benefit across PD-L1 subgroups
đ§ convincing data, new SOC?!
@myesmo @ASCO
Aron Simkins, MD retweeted
USA: not recognizing Spain in the Americas since 1898.
Spain will not recognize US intervention in Venezuela, PM says reut.rs/4sq5sxq reut.rs/4sq5sxq
Aron Simkins, MD retweeted
The Somali daycare fraud never happened
Zohran isnât a communist
Maduro was the good guy
~~~
These are mainstream Democrat positions right now â you can see that theyâre false just by opening your eyes
Aron Simkins, MD retweeted
Thereâs a good reason the US and dozens of other countries and cities have adopted the IHRA definition of antisemitism. When leaders move to revoke it, like what happened today in New York, it should alarm everyoneâespecially as violence against Jews is dangerously escalating.
Aron Simkins, MD retweeted
Never forget that hostages are being released and the war is endingâand the only reason this didnât happen sooner is because much of the world, including âhumanitarianâ organizations and the UN, sided with Hamas.
Never, ever forget.
Aron Simkins, MD retweeted
High agency is believing you can learn new things and work hard to solve tough problems no matter how complicated.
Low agency is sitting around making fun of people who try.
Aron Simkins, MD retweeted
The Yevsektsiya were Jews. They blamed âZionistsâ and traditional Jews for alienating Soviet society. They believed that if Jews behaved properly and complied with Communism, the regime would treat them well. When they were no longer useful, the Yevsektsiya were disbanded. Their members were executed or sent to labor camps.
The Antizionist League of Iraq were Jews too. They thought Zionists were the problem. They believed that if Jews in Iraq distanced themselves from the idea of a Jewish state, all the hatred would fade away. They were wrong. The League was dissolved, its leaders imprisoned, and Iraqâs Jews were slaughtered in the Farhud and driven out. Nobody asked whether they were Zionists before burning their homes or stabbing them in the streets.
A hundred years ago, Baghdad was more Jewish than New York City is today. Now there are fewer than ten Jews in the entire country. Trying to prove that youâre one of the âgood Jewsâ never works.
The same story played out in Germany. Jews there were the most assimilated in the world â cultured, loyal, and proud Germans. They thought the âbad Jewsâ were the Eastern European immigrants. The Association of German National Jews, who sought to align themselves with the Nazi Party, was outlawed. They were deported and burned along with the rest of European Jewry. Today, there are fewer Jews in all of Europe than there are Israeli Arabs in Israel. So much for Europe lecturing Israel about tolerance.
Once a society starts stigmatizing Jews â or even just a subset of Jews â the writing is on the wall. Assimilation and appeasement do not work. Explaining ourselves kindly and hoping to be accepted as the âgood onesâ does not work.
We are living in a dangerous time for Jews. The United States and perhaps Argentina are the last places where Jews are not broadly stigmatized. But that is changing. In a 2023 Harvard-Harris poll, two-thirds of Americans aged 18 to 24 said âJews as a class are oppressors and should be treated that way.â That is the future of public opinion.
We have no choice but to name antizionism for what it is. And we must do it now.
Because if âanti-Zionismâ were really about Bibi, it wouldnât have existed before Israel was founded. And yet Jews were being slaughtered under that same banner for centuries.
The truth is simple. Antizionism is a hate movement with hundreds of years of Jewish blood on its hands. It is systemic. It is global. It is deadly.
Kind explanations and compliance have never saved us. Only clarity, courage, and truth have.
Aron Simkins, MD retweeted
It is NOT a "both sides" issue.
No assassination attempts on Biden.
No assassination attempts on Kamala.
No assassination attempts on AOC.
No assassination attempts on any other prominent voice on the political left.
No violence from pro-Israeli crowds.
No arrests on the pro-Israeli side.
No calls for death or murder of those who oppose the pro-Israeli side.
Those who oppose gender ideology do not call for the death of those who disagree with them.
Those who oppose movements like BLM did not call for the death of those who took part in the BLM riots.
Social media is not flooded with videos from those on the right celebrating the deaths of those on the left or wishing harm upon them.
It is not a "both sides" issue.
Aron Simkins, MD retweeted
Israel was condemned for violating Ugandaâs sovereignty when it rescued hostages from Entebbe, and for violating Argentinaâs when it captured Nazi war criminal Adolf Eichmann. This is more of the same. Literally nothing changes.
Aron Simkins, MD retweeted
The Left lectured us for the last decade about the dangers of violence from the Right
From the assassination attempts of President Trump
To Brian Thompson, the United Healthcare CEO, being murdered
Now to Charlie Kirk
The danger was actually on the Left
Aron Simkins, MD retweeted
The number of @nytimes articles linking Israel to genocide were 9X higher than the peak for Rwanda, where 800,000 people were slaughtered in 100 days. In an interview with @thefp, U.S. Ambassador to Israel Mike Huckabee describes antisemitism as a virus that evolves to scapegoat Jews for whatever society deems its greatest plague.
The Holocaust is not a shield to deflect criticism of Israel. Itâs a warning of what happens when Jews are falsely accused of crimes they did not commit.
Aron Simkins, MD retweeted
Mahmoud Khalil refuses to condemn Hamas because he IS a terrorist sympathizer not because DHS âpaintedâ him as one. He âbrandedâ himself as antisemite through his own hateful behavior and rhetoric.
It is a privilege to be granted a visa or green card to live and study in the United States of America. The Trump Administration acted well within its statutory and constitutional authority to detain Khalil, as it does with any alien who advocates for violence, glorifies and supports terrorists, harasses Jews, and damages property.

































