Consultant Urologist @ImperialNHS • Prostate Cancer & BPH • HoLEP • Focal Therapy • Prostate cancer screening research • Building clinician-led AI
London, UK
Joined July 2009
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➡️In 1980s prostate MRI described by Steyn & Smith
➡️In 1990s mpMRI protocols were developed
➡️In 2000s a prebiopsy MRI was postulated by @LondonProstate1
➡️In 2010s mpMRI was proven to be highly accurate pre-biopsy
➡️In 2020s IP1-PROSTAGRAM evaluated fast MRI for screening
David Eldred-Evans retweeted
The #RADAR Study is now open!🚨
High risk men aged 40-49 will have a #Prostagram scan, a Stockholm3 test, and a PSA test to find the best way to screen for #ProstateCancer. Check if you can sign up here: imperial.eu.qualtrics.com/jf…
@NIHRresearch @ImperialSandC @ImperialNHS
David Eldred-Evans retweeted
🚀 Save the date for the Imperial Prostate Masterclass 2027! #ipmasterclass27
Join leading experts from around the world for cutting-edge lectures and hands-on training sessions! 🌍🔬
📅 Friday 16 April - Saturday 17 April 2027
🎟️ Register your interest: imperialprostatemasterclass.…
David Eldred-Evans retweeted
Reasonable precis of some of my work
You omitted another relevant bit though
The TRANSFORM screening RCT (that I am Chief Investigator for) in which focal therapy is mandated in the screening arms (n=150-300K) (£60M from @ProstateUK & UK National Institute for Health Research
Fantastic news! Please correct me if I’m wrong or missing anything as I wish to have a good understanding of the RCTs in this space
IP4-CHRONOS-A
Focal HIFU/cryo vs surgery/RT
Closed after pilot failed its feasibility criterion
IP17-APOLLO
Focal therapy ± 3 months neoadjuvant apalutamide
Does not establish focal therapy vs radical therapy
CHRONOS-B
Focal therapy alone vs focal + short neoadjuvant hormonal manipulation
Closed pilot. Feasible, but again not FT vs standard definitive treatment
IP2-ATLANTA
In de novo mHSPC: SOC vs ablative prostate treatment vs radical local therapy, with MDT strategies
Fascinating, but this is cytoreduction in metastatic disease, not a test of focal therapy as definitive localized therapy
PART
Partial ablation vs radical treatment
The most important UK RCT, but Ahmed is not the chief investigator
For partial ablation, the current protocol can allow a repeat focal ablation before declaring failure.
So, is there an RCT he is running that compares FT to definitive treatment?
Very interested to learn more if so or be corrected if I’m off the mark.
Thanks in advance and for all of the hard work!
David Eldred-Evans retweeted
Congratulations to @NikhilMayor who has been awarded a prestigious and highly competitive @NIHRresearch Doctoral Fellowship!
The £500k award provides an opportunity to optimise screening pathways using MRI - including a #ProstateCancer screening study called #RADAR, coming soon!
David Eldred-Evans retweeted
✅ Focal therapy for prostate cancer is effective over the long term
🏆A win for all those eligible patients who want a treatment for their significant prostate cancer with fewer side effects
🇬🇧 Amazing ‘Team UK’ endeavour for the last two decades to get us to this point!
🚨 NEW IN @EUplatinum! 🚨
The largest analysis of focal therapy by Imperial Prostate and UK colleagues, reporting 1⃣0⃣-year outcomes after focal HIFU and cryotherapy in 3⃣4⃣7⃣7⃣ men 🔥🧊
Led by @AJWLight @LondonProstate1 @TaimurShah
Read for free: europeanurology.com/article/…
David Eldred-Evans retweeted
Professor Ahmed completes his tenure as Chair of the UK Prostate Cancer Clinical Research Strategy Group (formerly NCRI Prostate CSG)
Supported by @ProstateUK @ProstateUKProfs @AMRC
Reflecting on a decade of the group’s work and passing the baton to the next Chair
📢 Just before @NCRI_partners wound down we created videos highlighting the #NCRIProstateGroup Strategic Priorities as we prepared to pass the torch to a new chair & new working group leaders. Hear about #WorkingGroupOne tomorrow! 👀
📄 Read the strategy: ncri.org.uk/groups/prostate-…
David Eldred-Evans retweeted
What a weekend! ⚽️
Also… huge honour to lead my first Focal One Robotic HIFU list!
@ImperialNHS @IP_London
Indebted to:
@LondonProstate1 @TaimurShah
@FocalOneHIFU @joshuarobotics
Dr Pierre Charles Henry (HIFU Proctor)
Dr Markovic (Anaesthetist)
Anmol & Alfin
Onwards & upwards. Delighted to add this fantastic focal therapy option to the armamentarium. Excellent user interface & image integration.
#HIFU #FocalTherapy #July4th #QuaterFinals – at Hammersmith, London
David Eldred-Evans retweeted
New paper out in @EurUrolOncol by @AJWLight
In this exploratory analysis of the #PROMIS and #PICTURE trials, performing MRI-targeted biopsy alone, without systematic biopsy, was found to be sufficient for planning focal therapy
Read for free! authors.elsevier.com/sd/arti…
Concomitant MRI-detected and MRI-undetected Prostate Cancer with Implications for Biopsy Strategies and Focal Therapy Planning: An Analysis of the PROMIS and PICTURE Trials by Alexander Light ... Taimur T. Shah et al
buff.ly/io6hfAR
With thanks to all the authors for publising your work in EUO!
@AJWLight @LondonProstate1 @TaimurShah
@uroweb
@mroupret
@GPloussard
@jteoh_hk
@Ric_Campi
@CaPsurvivorship
@LauraMarandino
@RenuEapen
@Ecastromarcos
@OncoAlert
@Sciencedirect
David Eldred-Evans retweeted
Similar to radical treatments in this risk profile of patients. Focal Therapy is not an alternative to active surveillance. We are treating majority of men who would be offered and advised to have radical therapy.
No screening without focal.
David Eldred-Evans retweeted
Focal therapy for prostate cancer
The term is too often used, but Alex’s and Taimur’s work, alongside our many collaborators, is truly ‘game changing’
@AJWLight @TaimShah
@FocalSociety @UkFocal
David Eldred-Evans retweeted
Interesting and fascinating data on PSA testing in different ethinic groups. Certainly not what we expected to see!
Well done Nikhil!
@NikhilMayor
@NikhilMayor kicks off the #ProstateCancer session at #BAUS2026 presenting variation in PSA testing amongst >350k men in London.
⭐️ Testing 24-30% higher amongst Black men
⭐️ Highest testing rates at the extreme of deprivation
Data from >12 million men coming later this year!
David Eldred-Evans retweeted
@NikhilMayor kicks off the #ProstateCancer session at #BAUS2026 presenting variation in PSA testing amongst >350k men in London.
⭐️ Testing 24-30% higher amongst Black men
⭐️ Highest testing rates at the extreme of deprivation
Data from >12 million men coming later this year!
David Eldred-Evans retweeted
📣The £42M TRANSFORM study will get a £20M boost so that all eligible Black men are invited to join stage 2
📶Policies on healthcare for any group to be based on evidence
🇬🇧Govt also funding wider access to focal prostate therapy to ⬇️ harms of surgery & radiotherapy
We're expanding research, widening treatment options and tackling inequalities in prostate cancer care.
✅ All eligible Black men will be invited to join a landmark screening trial.
✅ A targeted NHS screening programme will also be rolled out.
More: gov.uk/government/news/major…
David Eldred-Evans retweeted
📣The £42M TRANSFORM study will get a £20M boost so that all eligible Black men are invited to join stage 2
📶Policies on healthcare for any group to be based on evidence
🇬🇧Govt also funding wider access to focal prostate therapy to ⬇️ harms of surgery & radiotherapy
TRANSFORM study extends prostate cancer screening to Black men in the UK
S&C's @LondonProstate1 welcomes the news that all eligible Black men in the UK will be offered prostate cancer screening as part of the landmark TRANSFORM study ⬇️
imperial.ac.uk/news/articles…
David Eldred-Evans retweeted
This is the correct decision and we should now double down on our resolve to do the science to find better screening tools and better treatments for men with prostate cancer.
👏Great news from DHSC supporting PCa research & better evidence for Black men
🔬 PCa screening policy must be built on robust evidence.
📈Expanding TRANSFORM will help generate evidence for earlier, fairer and safer screening
gov.uk/government/news/major…
@zubirahmed @DavidLammy
Last operating list with my ex-@IP_London colleague Mr Ed Bass before he joins GSK as a Medical Director
Ed has been a brilliant colleague & friend.He’ll be hugely missed, but I can’t think of anyone better suited to help shape GSKs next generation of prostate cancer treatments
Brilliant academic, hugely skilled HoLEP surgeon and one of the cleverest people I know. I’m genuinely sad to see him leave the NHS, but @GSK is lucky to have him. Looking forward to seeing what he does next for in prostate cancer research.
David Eldred-Evans retweeted
#IBUS26 Excellent talk on current policy for prostate cancer in the UK. Fit for purpose? The always insightful @SimonBott6 with an audience assist from TRANSFORM’s @LondonProstate1
Don’t miss our live AI infographic. Catch all the action from IBUS 2026 at Royal Armories Leeds!
