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'Bridging scales' from #smallmolecules to #cells. How can we combat the development of #humandiseases like #cancer? Max Planck Institute of Molecular Physiology

Dortmund, Deutschland
Joined March 2016
Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)Photo by MPI Dortmund (@mpimoph)
Take a look at this recently published paper in LSA: Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking @mpimoph hubs.la/Q04vF1-_0
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Medium ligand-composition and concentration modulates EGFR signaling competency at the plasma membrane, balancing crypt proliferation and villus differentiation, enhancing mouse intestinal organoids self-renewal. @mpimoph hubs.la/Q04vDq760
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We want you! Join the Department of Molecular and Cellular Biology @MoCel_Geneva at the University of Geneva @unige_en @UNIGEnews @sciences_UNIGE and become our new colleague! Assistant (tenure-track) Professor or Associate Professor! Please RT - thanks jobs.unige.ch/www/wd_portal.…
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MPI Dortmund retweeted
One lamella, one tomogram! Excited to share our preprint on streamlining montage cryo-tomogram generation including the use of our software tool MontageMaker! Big thanks to @maikaboiero, @adriana_prajica, @GavinRice20, @Intein, and the team at @mpimoph! biorxiv.org/content/10.1101/…
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Ein starkes Signal für Wissenschaft und Innovation! Vielen Dank an den Freistaat Bayern, @Markus_Soeder und @MarkusBlume für die Unterstützung beim Ausbau der #Spitzenforschung und der Life-Sciences in Bayern.
Bayern ist eine führende Hightech-Region in Europa. Heute war dazu ein weiterer Meilenstein im Kabinett: Wir starten Europas stärksten Life-Science-Campus in Martinsried bei München gemeinsam mit der Max-Planck-Gesellschaft. Das ist zentral für den Pharma- und Medizinstandort Bayern. Es geht um Grundlagen und klinische Forschung für Bio-Intelligenz und Bio-Chemie etwa zur individualisierten Krebstherapie. Wir machen dazu ein umfassendes Update für 2000 Mitarbeiter aus 50 Nationen mit insgesamt 500 Mio. Euro vom Freistaat Bayern. Vier Nobelpreisträger haben wir schon – viele weitere sollen folgen. Auf einem Bio-Campus mit eigenem KI-Rechenzentrum sollen sich insbesondere Start-ups entwickeln. Um das Ankerprojekt in Martinsried wird sich bis 2050 eine Zukunftsachse „Bio-Life-Science“ für ganz Bayern bilden, etwa mit der Uni Würzburg. Hightech ist der Schlüssel der Zukunft. Biomedizin und Lifescience sind ein klarer Schwerpunkt unserer Aktivitäten neben KI, Quantencomputing und Luft- und Raumfahrt. Insgesamt ist Bayern die Nummer 1 in Deutschland mit der Hightech Agenda und bei Start-ups. Der Freistaat hat bei Forschung und Entwicklung einen BIP-Anteil von 3,4 Prozent – nur Schweden ist in ganz Europa noch ein kleines Stück weiter vorn. Mit der Hightech Agenda stellen wir insgesamt sechs Milliarden Euro für Forschung und Wissenschaft bereit. Nie gab es eine größere Offensive für Innovation und Technologie.
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Recently published: Uncovering Novel #lncRNAs Linked to #Melanoma Growth and Migration with #CRISPR-Inhibition Screening, by Stavroula Petroulia et al. doi.org/10.1158/2767-9764.CR… @ewang2323 @artsinyc @mpimoph @nyugrossman #CRISPRi #OpenAccess
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Your PhD journey starts NOW! Join our #webinar on Sept 4 (1-3 PM CEST) to explore #PhD opportunities at Max Planck's #PhDprograms in NRW, Germany! 🇩🇪 Gain insights into groundbreaking research & register here: events.gwdg.de/e/PhDatMaxPla… #MaxPlanck #Research #Germany #Science
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🚀 Exciting news for early-career researchers! The new Max Planck #Postdoc Program offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. Applications are open now! postdocprogram.mpg.de #ScienceCareer #PostdocProgram
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Interactions with multiple inner #kinetochore proteins determine mitotic localization of FACT, say Julia Schweighofer, Bhagyashree Mulay, Andrea Musacchio and colleagues @mpimoph: hubs.la/Q03c4Rjw0 #Mitosis
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We are delighted to announce that the 3rd DivIDE Conference will take place from 22–25 September 2025 with a fantastic lineup of speakers. Registration opens soon - stay tuned and help us spread the word! We are looking forward to meet many of you in Barcelona! ☀️
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‼️Save the date‼️The new Max Planck #Postdoc Program kicks off its first call for applications from April 1, 2025; applications can be submitted until May 13, 2025. mpg.de/en/max-planck-postdoc… #ScienceCareer
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Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jmedchem… #CancerResearch #DrugDiscovery
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I encourage you to apply to join us at @UCBerkeley !
Scientific Director, Cal-Cryo. We're looking for an outstanding microscopist to run our cryo-EM facility (two Krioses and an Arctica). Apply now to join our outstanding community of cutting edge cryo-EM/ET researchers! tinyurl.com/ykasna3p
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I am very happy to share that our paper on the "Multistate kinetics of the syringe-like injection mechanism of Tc toxins" is finally online. lnkd.in/ezh4ji26 A HUGE thank you to Stefan Raunser @Intein & @mpimoph for giving me the opportunity to work on this project 1/3
Very excited to share our preprint on the multi-state kinetics of the syringe-like injection mechanism of Tc toxins. Great collaboration between the Raunser @Intein @mpimoph, Seidel @HHU_de, @enricabordignon @sciences_UNIGE and Dong @harvardmed labs. biorxiv.org/content/10.1101/… 1/3
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Last week, we proudly celebrated the Cliff S. Hamilton Award, honoring the exceptional achievements of Prof. Herbert Waldmann & outstanding graduate student Momodou Camara. Thank you to everyone who joined us in recognizing these remarkable contributions to the field!
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Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s41589-0…
For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)
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MPI Dortmund retweeted
Thrilled to share our reviewed preprint in @eLife on the activation mechanism of Mical1! Heartfelt thanks to Petra Janning, Ingrid Vetter, and @GoodyRoger for their invaluable support and contributions! @mpimoph elifesciences.org/reviewed-p…
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🏆 We are proud to announce that Aylin Binici (Waldmann lab), Jennifer Harris @knifeyjen (@LabWestermann) and Georg Geobel (Wu lab) have successfully defended their PhD thesis and are now Doctorate degree holders! Well deserved! All the best for your next projects! #PhDdone
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