asst professor at UConn; multiscale simulations of cells; questing for the essence of life and its boundaries

Joined July 2018
Check out my new website design! 🎉 We’ve embedded #Simbrain right in the browser—move nodes, tweak activations, add connections, and more! Try it out at jeffyoshimi.net. Hover over my name and click ? for commands. #AI #NeuralNetworks
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🔥Absolutely thrilled to share a pair of papers out in @CellPress of work done with @garrypnolan. 🔬 T cell mediated restructuring of the tumor microenvironment - doi.org/10.1016/j.celrep.202… 🧬 Extracting spatiotemporal mechanisms from spatial-omics data - doi.org/10.1016/j.cels.2024.…
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One hope of biology is to collect enough data to model "reality" in the computer. This could allow one to ask/answer questions that are nearly impossible to ask in the lab. Here, we show that collecting the raw data on cell positions in multiple stages of a mouse cancer model provides enough raw data on the system's "state" to create computer models with free agent algorithms and discover a critical step in how T cells can successfully act against a tumor. The manuscript was written by Hickey et al. and our colleagues from the Sunwoo and Covert labs at Stanford. Integrating multiplexed imaging and multiscale modeling identifies tumor phenotype conversion as a critical component of therapeutic T-cell efficacy (sciencedirectassets.com)
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Explore the power of #PhenoCycler #multiplexed imaging with today's #FridayRead, centered on two groundbreaking studies published in @CellPressNews Journals. The first study provides in situ mechanistic insights into temporal tumor microenvironment changes, cell interactions critical for response, and spatial correlates of immunotherapy outcomes, informing cellular therapy evaluation and engineering. bit.ly/3UoQ9VV The second study unveils new design criteria and patient selection metrics for T-cell therapies, calls for a rethinking of T-cell therapeutic implementation, and provides a foundation for synergistically integrating multiplexed imaging data with multiscale modeling of the cancer-immune interface. bit.ly/3vQgfsD 👏 Congratulations to Dr. John Hickey from @DukeU and his co-authors on their valuable insights raising the bar for #cancerresearch! @johnhickey22 @GarryPNolan
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Seeking a postdoctoral fellow in Whole-Cell Model-Driven Gene Function Discovery with a PhD in Computational Biology or related field, skilled in simulation, data analysis, and Python. Apply now: basis.ai/roles/postdoc-eran-… On LinkedIn: linkedin.com/jobs/view/38731… Email: [email protected]
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Join the Longo Lab as a PostDoc! Details here: jinjika.jim.titech.ac.jp/job… Please share widely!
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What's your favourite #protist? Magnificent protist image resource from Yana Eglit & @pjkeelinglab just out in @PLOSBiology journals.plos.org/plosbiolog…
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Version 23 of the Human Protein Atlas is released including an updated genome assembly, a new Interaction section with data for human protein-protein interaction networks, and lots of other updates. Read more proteinatlas.org/news/2023-0…
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Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes. elifesciences.org/articles/8…
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Sharing great news – Excited to announce I will join @Duke as an assistant professor in @DukeBME starting January 2024! My lab will leverage computational, biomaterial, and spatial-omics tools to probe/control tissue structure in situ, focusing on advancing cell therapies (1/8).
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📣 Announcing C-CoMP's NEW Faculty Fellow Program! This 2 yr program supports faculty whose research complements C-CoMP’s research: tinyurl.com/4nfc6xsd. Please share with your networks! #LatinXinSTEM #BlackandSTEM #DisabledinSTEM #NativeinSTEM #QueerInSTEM #DiversityinSTEM
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Link to a fully-funded PhD opportunity in my lab at @UTRGV - Linking prebiotic chemistry & Darwinian evolution. We're receiving many applications, but we might be missing the best one: yours. Jump on the train of wet lab & modeling integration! 🧪🖥️👩‍🔬 phdinsiders.com/job/astrobio…
Can you model + also interested in the wet lab? Want to do a PhD on #originoflife? I have a fully-funded project in my lab at @UTRGV consisting of coupling prebiotic chemistry to membrane biophysics to study primitive Darwinian evolution #astrobiology utrgv.edu/graduate/for-futur…
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Fantastic to see my PhD advisor continue pushing his analysis of the game of life ever farther, revealing deep insights about the nature of life and mind.
Randall Beer talked about "the daily life of the glider" inside Conway's Game of Life. Yap, being a sensitive glider, surviving in a random world is not easy... youtube stream: youtube.com/watch?v=kbGXonL6… 1/n
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Eran Agmon retweeted
This is so upsetting. Even after seeing the proof I still had to spend hours drawing this to placate myself.
These shapes are topologically equivalent (!)
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HARMONY 2023 - Registration is Open reproduciblebiomodels.org/ha… HARMONY 2023 will be hosted by @HerbertSauro and the @reprobiomodels, primarily as an in-person meeting, w/individual breakout sessions & optional remote participation. Conference Date 24-27, April 2023 Seattle, WA
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📣🌊Save the Date! C-CoMP is hosting 3 virtual info sessions about our #BridgetoPhD and #Postdoc Fellowships this March. Register to attend an info session here: signupgenius.com/go/10c094aa… #LatinXinSTEM #BlackandSTEM #DisabledinSTEM #NativeinSTEM #QueerInSTEM #DiversityinSTEM
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Any prospective postdocs interested in computational modeling of the ocean microbiome? This might be the opportunity you're looking for. please DM me.
📣🦠We are looking for our next C-CoMP #Postdoc Fellowship cohort! Consider applying if you are interested in working with us to study the chemicals and microbial processes that underlie the surface ocean carbon cycle. Please RT! tinyurl.com/25hty8a9 #DiversityinSTEM
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In September 2022, @AccelerateSci @ml4science and @datascience_uw, convened 30 researchers from across disciplines at a @dagstuhl workshop on ‘Machine learning for science: bridging data-driven and mechanistic modelling’. The result: a beautiful roadmap acceleratescience.github.io/…
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