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Sisi Chen

@sisichen

Scientist @ Caltech. Ph.D. Director of @SPEC_Caltech. Computational biology, big data, immunology, and stem cells. | Writer | Artist | She/her

 Los Angeles
Joined March 2009
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Photo by Sisi Chen (@sisichen)Photo by Sisi Chen (@sisichen)Photo by Sisi Chen (@sisichen)
maximally informative. Her method is very resource efficient, allowing her to compute >1M cells on a fairly typical AWS instance. nature.com/articles/s43588-0…
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We are hiring!! Looking to hire a research technician to execute a focused project on exploring human cell surface proteins on the human immune system using single-cell RNA-seq. phf.tbe.taleo.net/phf03/ats/…
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Waterbear riding a Volvox! 📸 Penny Fenton
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New preprint from our lab on whole animal multiplexed #scRNAseq (WHAM-seq) by Tara Chari, Brady Weissbourd & @JaseGehring et al. collaborating w/ David Anderson, Evelyn Houliston @Clytia_Vlfr, and @richcopley. A 🧵 about our proof of principle in🎐... 1/ biorxiv.org/content/10.1101/…
Whole Animal Multiplexed Single-Cell RNA-Seq Reveals Plasticity of Clytia Medusa Cell Types

Whole Animal Multiplexed Single-Cell RNA-Seq Reveals Plasticity of Clytia Medusa Cell Types

We present an organism-wide, transcriptomic cell atlas of the hydrozoan medusa Clytia hemisphaerica, and determine how its component cell types respond to starvation. Utilizing multiplexed scRNA-seq,...

biorxiv.org
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Synthetic biology for therapy will require control of population density. Can you design a quorum sensing system that enables cells to sense, respond to, and control their own population density? We designed one with a paradoxical control circuit. /1 biorxiv.org/content/10.1101/…
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Nature Communications retracts much-criticized paper on mentorship retractionwatch.com/2020/12/…
Image from Retraction Watch (@RetractionWatch)
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We identified and characterized tumor-directed circulating T cells in peripheral blood, using single-cell RNA-seq and TCR. Surprise!!(?)- there are *many* such cells, and the large majority doesn't express PD1. HUGE THANKS to my amazing colleagues! biorxiv.org/content/10.1101/…
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA sequencing and T cell receptor (TCR) sequencing to...

biorxiv.org
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*Updated Biden leads* in Georgia: 1,560 in Arizona: 43,779 in Pennsylvania: 12,390 in Nevada: 20,542 Below is the % of the outstanding votes Trump would have to get to overtake Biden. Then what he's actually getting GA: 66.6%/31.1% AZ: 58.4%/52.3% PA: 53%/19.6% NV: 58.9%/38.4%
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I just looked up my ballot online and saw it was rejected because of something re my signature. I called and was able to fix it with a series of identity confirming protocols. If you live in a state where you can check on your ballot online please do! I never would have known.
Image from Andrea Gibson (@andreagibson)
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No, Trump has not already won the election, and it is deeply irresponsible for him to say he has.
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Happy to share our review (first pub from our lab!) on how optogenetics can be used to understand and engineer multicellular systems, led by @tumboThomas and @LeeeRoth sciencedirect.com/science/ar….
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.@KamalaHarris is every woman in the workplace.

Kamala Harris is every woman in the workplace.

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Sisi Chen retweeted
Sisi Chen (@sisichen) profile picture
Sisi Chen@sisichen21 Jun 2020
It’s like Trump never made it past the “object permanence” stage of childhood development.
Aaron Rupar (@atrupar) profile pictureAaron Rupar
@atrupar21 Jun 2020
Replying to @atrupar
"Here's the bad part: When you do testing to that extent, you're gonna find more people, you're gonna find more cases. So I said to my people, 'slow the testing down please!'" -- Trump
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"For every atom belonging to me as good belongs to you. Remember?" Poet Marie Howe's ode to Stephen Hawking, our cosmic belonging, and the meaning of home, in a stunning animated short film: brainpickings.org/2020/04/23…
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Great "SARS-CoV-2 #COVID19 by the numbers" piece in @eLife today from @flamholz @MiloLabWIS @yinonbaron and Rob Phillips. They will be updating it frequently as new data come in and new things to track come up. Full peer-reviewed figure and analyses here cdn.elifesciences.org/articl…
Image from Michael 英泉 Eisen (@mbeisen)
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