The excellent outcome of #INPST-based collaborative work
#NaturalProducts #DrugDiscovery
By: @_INPST @_atanas_ @univienna @LBG_research @FrancescaGiamp5 @Bio_Lab_UNIVPM @DHPSP @maciejbanach @ilkay_E_ORHAN @BgSciencesBAS @docmmiller @UNI_FIRENZE @NatRevDrugDisc @MedUni_Wien
Natural products in drug discovery: advances and opportunities - a new review published today from @_INPST go.nature.com/2YmK1kb @_atanas_ Readcube version rdcu.be/cem6r
International Natural Product Sciences Taskforce retweeted
“Late-life semaglutide treatment slows ageing and extends lifespan in female mice.” Published September 02, 2026, Nature
nature.com/articles/s41586-0…
International Natural Product Sciences Taskforce retweeted
Cholinergic Balance / Gut Metabolites/ Butyrate / AhR/ Epithelial Regulation / IBD / Inflammation
LPS induced inflammatory cytokine expression and barrier disruption, whereas SCFAs and indole derivatives significantly reduced inflammation, restored tight-junction organization, and decreased permeability. These metabolites enhanced CHAT and muscarinic receptor expression while suppressing ACHE upregulation, indicating restoration of cholinergic balance. Both groups reactivated AhR signaling, and AhR inhibition disrupted cholinergic regulation, supporting an AhR-dependent mechanism. Butyrate and indole-3-butyric acid exhibited the strongest protective effects. These findings identify a novel AhR–cholinergic axis in intestinal epithelial regulation and highlight microbial metabolites as promising therapeutic candidates for IBD.
Crosstalk through cholinergic and aryl hydrocarbon receptor pathways in the anti-inflammatory actions of microbial metabolites
link.springer.com/article/10…
International Natural Product Sciences Taskforce retweeted
Association between iron deficiency anemia (IDA) & accelerated biological aging: evidence from U.S. & Chinese cohorts
Highlights:
▶️ IDA is associated with accelerated biological aging in U.S. and Chinese cohorts.
▶️ Sensitivity analyses confirmed the robustness of the association.
▶️ Addressing IDA may promote healthy aging across diverse populations.
sciencedirect.com/science/ar… @Mangan150
@DHPSP @nuclearball @FarmerJeff252
IDA was associated with a 9.11-year higher PhenoAge residual in NHANES
✅️ These findings demonstrated a convergent, cross-national link between IDA and accelerated aging.
International Natural Product Sciences Taskforce retweeted
WHO Special Envoy José Luis Castro: Chronic Lung Diseases 🫁 Affect Around Half a Billion People, Yet Continue to Be Overlooked
Chronic lung diseases, such as chronic obstructive pulmonary disease #COPD and asthma, affect half a billion people worldwide, and COPD is the third leading cause of death. Nevertheless, these conditions receive less attention in national health policies than cardiovascular diseases and cancer, @JLCastroGarcia of the @WHO told the Polish Press Agency (PAP).
Since 1 September 2024, Castro has served as the WHO Director-General’s Special Envoy for Chronic Respiratory Diseases (CRDs).
On 25 September this year, José Luis Castro visited Poland to participate in a conference held at the Polish Parliament (Sejm) entitled “The Lungs of Poles: Challenges and Priorities for Public Health,” organized as part of the observance of #WorldLungDay.
“People generally associate #lung diseases with infectious causes, such as tuberculosis. These diseases do indeed affect millions of people worldwide. But there are also chronic lung diseases, such as asthma and COPD, which affect half a billion people and cause four million deaths annually. Despite this, public awareness of these conditions remains significantly lower,” Castro told PAP.
The expert recalled that chronic obstructive #pulmonary disease (COPD) is considered the third leading cause of death worldwide. Yet it is rarely the subject of media coverage. According to the International #Respiratory Coalition, citing data from the Global Burden of Disease 2023 study, more than 38 million people in the European region live with COPD.
“When I took up my position at WHO in 2024, I reviewed articles and media reports about chronic lung diseases (...) and found one article published in The New York Times that mentioned COPD as the cause of death of Sinéad O’Connor [the Irish singer-songwriter],” Castro recalled. He emphasized that the disease had received coverage only because it affected a celebrity.
In his view, one of the problems surrounding COPD is that it continues to be mistakenly perceived as a disease affecting only older people and smokers, contributing to the stigmatization of patients.
“COPD does not affect only older people or smokers. It also affects people who have never smoked, and the factors that predispose someone to develop the disease may arise very early in life. Air pollution, exposure to harmful substances in the workplace, and factors affecting lung development all contribute to the disease,” the specialist explained.
He emphasized that everyone living with COPD deserves a timely diagnosis, effective #treatment, and care free from stigma.
Full piece at naukawpolsce.pl/aktualnosci/…
International Natural Product Sciences Taskforce retweeted
How the insula and anterior cingulate interact to produce "sickness behavior".
The anterior insular cortex (AIC) and the anterior cingulate cortex (ACC) function as a coupled input-output hub—often central to the salience network—that translates peripheral immune signals into the subjective feelings and behavioral adaptations of sickness behavior. [1] (pmc.ncbi.nlm.nih.gov/article…), [2] (pmc.ncbi.nlm.nih.gov/article…), [3] (pmc.ncbi.nlm.nih.gov/article…)
1. Interoceptive Sensing and Input (Anterior Insula)
• Immune-to-Brain Communication: Peripheral inflammatory mediators (such as cytokines like IL-1β, TNF-α, and IL-6 released during infection or endotoxin challenges like LPS) signal the brain via vagal afferents and circumventricular organs, projecting to the brainstem (nucleus of the solitary tract and parabrachial nucleus) and up to the thalamus. [1] (pmc.ncbi.nlm.nih.gov/article…), [2] (pmc.ncbi.nlm.nih.gov/article…), [3] (pmc.ncbi.nlm.nih.gov/article…)
• Primary Interoceptive Mapping: The posterior and mid-insula initially map these raw physiological and visceral changes (e.g., muscle aches, thermal shifts, gastrointestinal distress). [1] (pmc.ncbi.nlm.nih.gov/article…), [2] (sciencedirect.com/topics/imm…), [3] (pmc.ncbi.nlm.nih.gov/article…)
• Re-representation and Sensation: The anterior insula re-represents these signals to create conscious feeling states, generating the subjective experience of malaise, fatigue, nausea, and body pain. Research using models like endotoxin administration shows marked increases in functional connectivity between the left anterior insula and the mid/anterior cingulate cortex that directly correlate with self-reported global sickness and back pain. [1] (pubmed.ncbi.nlm.nih.gov/2673…), [2] (sciencedirect.com/science/ar…), [3] (pmc.ncbi.nlm.nih.gov/article…)
2. Coordination and Behavioral Output (Anterior Cingulate Cortex)
• Action and Motivational Orchestration: Once the anterior insula registers the internal distress signal, it communicates directly with the anterior cingulate cortex (including the pregenual and midcingulate subregions). [1] (pmc.ncbi.nlm.nih.gov/article…), [2] (pmc.ncbi.nlm.nih.gov/article…), [3] (pmc.ncbi.nlm.nih.gov/article…)
• Autonomic and Motor Adjustments: The ACC projects heavily to subcortical and autonomic nuclei (such as the hypothalamus, periaqueductal gray, and amygdala) to orchestrate the physiological response—driving fever, neuroendocrine changes (HPA-axis activation), and sympathetic/parasympathetic shifts. [1] (link.springer.com/article/10…), [2] (pmc.ncbi.nlm.nih.gov/article…)
• Behavioral Conservation: The ACC-insula circuit shifts motivational priorities away from energy-consuming external goals (socializing, foraging, physical work) toward conservation, rest, and social withdrawal, which help the body reallocate metabolic resources to fight the pathogen. [1] (pmc.ncbi.nlm.nih.gov/article…), [2] (pmc.ncbi.nlm.nih.gov/article…)
For a broader breakdown of how deep brain regions map these internal states, see recent research highlights like Stanford Maps Insula's Sensory and Emotional Regions. [1] (chosun.com/english/industry-…)
What if your thoughts became your next interface? 🧠
Brain-computer interfaces (BCIs) are moving beyond the lab.
In 2026, a patient used a BCI at home for 3,800+ hours, producing nearly 2 million words [1]. Neuralink reported 21 trial participants worldwide [2].
And researchers demonstrated brain-controlled hearing that identified a listener's chosen voice with up to 90.3% accuracy [3]. 🚀
The opportunity extends beyond healthcare: AI, accessibility and human-machine interaction could become major competitive frontiers.
But scaling demands more than innovation. Leaders must address affordability, neural-data privacy and clinical safety.
🤔 Who should control the next human interface: patients, technology companies or regulators?
Sources:
[1] [nature.com/articles/s41591-0…](nature.com/articles/s41591-0…)
[2] [neuralinktrials.com/updates](neuralinktrials.com/updates?…)
[3] [nature.com/articles/s41593-0…](nature.com/articles/s41593-0…)
#BCI #Neurotechnology #Neuralink #HealthTech
International Natural Product Sciences Taskforce retweeted
Brighter days linked to better sleep, study finds
manchester.ac.uk/about/news/…
Take a deep dive:
Light exposure and sleep architecture in real-world settings
nature.com/articles/s44323-0…
International Natural Product Sciences Taskforce retweeted
What are these two laughing about? Find out October 27th. #PeopleWorthCaringAbout #CelebratingLifeStories #WeArePalmGarden
International Natural Product Sciences Taskforce retweeted
Change doesn’t start with everyone agreeing.
It starts with one person willing to promote it.
International Natural Product Sciences Taskforce retweeted
The ACID trial brings valuable clinical evidence to the detection of neoplastic Barrett’s oesophagus, with potential to strengthen endoscopic assessment and support more precise identification of high-risk lesions. #Health
#BMJResearch: Acetic acid chromoendoscopy for detection of neoplastic Barrett’s oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial)
bmj.com/content/395/bmj-2026…
International Natural Product Sciences Taskforce retweeted
4 MINUTES a day cut the risk factors that send older adults into nursing homes.
A 12-week randomized trial of 97 adults (average age 74) tested a simple home routine. Compared with the control group, the exercise group gained:
• 4.2 more chair stands in 30 seconds
• 3.6 extra seconds of one-leg balance
• 2.3 seconds faster on the sit-to-stand test(PLOS One, 2026)
The whole thing took four minutes:
30 seconds each of wall push-ups, chair stands, resistance-band rows, and stair steps, with 30 seconds of rest between moves. Participants stuck with it on 81% of days.
These small improvements in getting up, balancing, and standing build the functional strength that keeps people getting out of chairs, walking out the door, and living on their own terms longer.
Try the 4-minute version tomorrow. No gym required.
Which of the four moves feels like the easiest one to start with?
#StrengthTraining
International Natural Product Sciences Taskforce retweeted
Well said, Fabrice. Leadership means bringing reliable care beyond major centers.
@myESMO @FAndreMD @curijoey @DrChoueiri @OncoAlert @OpenMedicineHQ #ESMO26
International Natural Product Sciences Taskforce retweeted
Replying to @readswithravi
International Natural Product Sciences Taskforce retweeted
Hepatitis B control after treatment ends? FDA-approved Hibsago offers that possibility for certain adults without cirrhosis. A 24-week trial result, with serious risks requiring monitoring.
fda.gov/news-events/press-an…
International Natural Product Sciences Taskforce retweeted
“Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study.” Published October 05, 2026, Nature Metabolism
nature.com/articles/s42255-0…
International Natural Product Sciences Taskforce retweeted
A new @WHO report reveals that noncommunicable #NCDs diseases like cancer, heart disease, and diabetes, along with their risk factors, disproportionately impact the poorest and most disadvantaged populations within countries.
This first comprehensive global assessment highlights that people with lower education and income often face higher risks from #tobacco, alcohol, and #airpollution, and frequently receive worse care, such as lower cancer screening rates and less access to hypertension treatment in rural areas.
To close these unjust gaps, countries must prioritize equity-oriented policies, strengthen primary #health systems, and invest in collecting better disaggregated data to ensure that life-saving interventions actually reach the populations most in need.
who.int/data/inequality-moni…
International Natural Product Sciences Taskforce retweeted
FT mice exhibited restored circadian rhythmicity of hepatic SIRT1 and PPARα protein expression compared to the disrupted patterns in FA mice,
pmc.ncbi.nlm.nih.gov/article…
International Natural Product Sciences Taskforce retweeted
Circulating vitamin D metabolites are distinctly associated with all-cause and cardiovascular mortality: a prospective study
✅️ Higher 25(OH)D3 levels were associated w/lower risks of all-cause & CVD mortality, whereas 25(OH)D2 showed no significant associations w/mortality.
Highlights:
▶️ Serum 25(OH)D₃ was associated with lower risk of all-cause & CVD mortality.
▶️ A nonlinear association was observed between 3‑epi-25(OH)D3 & mortality.
▶️ Serum 25(OH)D₂ was not significantly associated w/mortality.
▶️ Alkaline phosphatase & albumin may mediate 25(OH)D₃-mortality associations.
sciencedirect.com/science/ar…
@Mangan150 @ScienceCommuni2 @_atanas_ @DrRPalmquist @nuclearball @drfherediaz @guani_vic @chidambara09 @FarmerJeff252
International Natural Product Sciences Taskforce retweeted
Endogenous GLP-1 peptides may help protect the gut from immune-mediated damage by reducing inflammation and supporting mucosal repair. These findings reinforce their potential role in maintaining intestinal health and barrier integrity. #healthcare
GLP-1 peptides protect the gut from immune injury.
Essential role of endogenous GLP-1 family peptides to reduce inflammation and restore mucosal integrity in the experimental model @DanielJDrucker @CellRepMed
cell.com/cell-reports-medici…
International Natural Product Sciences Taskforce retweeted
Meal timing as medicine: clinical evidence for intermittent fasting in Huntington's disease
"to our knowledge, the first clinical evidence that time-restricted eating is feasible in people with HD and may influence disease-relevant clinical and biological measure"
nature.com/articles/s42255-0…




























