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AgelessRx retweeted
🧬 Longevity & Aging Series (S3, E6):
Girish Harinath @agelessrx_ discusses “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.”
🎥 youtube.com/watch?v=7-NvskI8…
#interview #aging #rapamycin #geroscience #longevity #healthspan #series #meded
When asked what top athletes are using to enhance performance and recovery around this year’s Olympics, Andrew Huberman pointed to vasodilators like Tadalafil.
Not for ED, but to support blood flow across the heart, brain, and muscles.
That raises a bigger question:
Have PDE5 inhibitors been too narrowly framed as treatments for ED, while their roles as exercise-mimetics enhancing vascular health, recovery, and brain function remain underexplored?
A Nature study suggests our environment may be accelerating brain aging.
Traffic exhaust and cooking fumes were associated with 7x faster brain aging, likely through oxidative stress + inflammation.
Could air purifiers + antioxidant support have a measurable impact?
nature.com/articles/s41591-0…
Should air quality be measured like a brain-health intervention, not dismissed as vague wellness advice?
Curious where cross-disciplinary thinkers fall here: @DrGlorioso @GaryWMiller3 @RimaHabre_ScD @MichaelOkun
60% of GLP-1 patients in a NYT survey said they’d stay on them even without weight loss.
Why?
Better memory, fertility, joint pain, brain fog, anxiety, and cravings.
The paper suggests inflammation may be part of the story. Could lower doses open new treatment paths?
nytimes.com/interactive/2026…
Curious how those with deep mechanistic understanding think about this: @DanielJDrucker @agingroy @agingdoc1 @Ashwinreads
Can lower-dose GLP-1s capture inflammatory benefits, independent of weight loss?
When researchers removed the gut mitochondria’s ability to sense Metformin, these effects disappeared, including its blood sugar-lowering effect.
@HillaryLinMD @DarshanShah_MD @agingdoc1 @NeilpDo
Does this change how you would prescribe or educate patients on Metformin?
For years, Alzheimer’s research has focused heavily on targeting brain plaque. But this research raises a bigger question: have we been overlooking a more upstream mechanism?
cell.com/cell-reports-medici…
Even more promising, human brains with Alzheimer’s appear to show similar patterns of low NAD+ and molecular dysfunction.
Curious to hear from leaders in the field: @BKennedy_aging @davidasinclair @DrGlorioso @thegarybrecka
Are we underestimating NAD+ biology in Alzheimer’s?
As thousands of people take Rapamycin for longevity, one of the biggest questions is whether the benefits seen in the lab will translate to humans.
This study suggests biomarkers of autophagy, or cellular waste clearance, may help predict who is most likely to benefit earlier on, based on changes happening at the cellular level.
link.springer.com/article/10…
@HillaryLinMD @agingroy @agingdoc1 @mkaeberlein @ggottschalkPhD
As we move closer to precision longevity medicine, which biomarkers are you most excited about?