@elyn_rowe

PhD Student & Vanier Scholar at the University of British Columbia | Check out @AMiNDR_podcast

 Vancouver, British Columbia
Joined September 2012
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long travel days this holiday season? check out my most recent @AMiNDR_podcast episode to catch up on the latest research on vascular contributions to Alzheimer disease! open.spotify.com/episode/35C…

309 - Vascular Changes in Alzheimer's Disease: August 2022

AMiNDR: A Month in Neurodegenerative Disease Research · Episode

open.spotify.com
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My thoughts on the phase 3 results of Alzheimer's drug lecanemab from Biogen and Eisai, presented at #CTAD #CTAD22 and published this evening in the @NEJM. Major takeaway – this is NOT the breakthrough we have been waiting for. Key points:
Neuroitic plaque (stained green) surrounded by dystrophic neurites (faint red) and microglia (brighter red). SchragLAB

ALT Neuroitic plaque (stained green) surrounded by dystrophic neurites (faint red) and microglia (brighter red). SchragLAB

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The first four years of my PhD @PhDVoice @PhDspeaks #PhD xitter.cf/DetJessRamirez/status/… – at Melbourne, Victoria
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Were two separate, major lines of Alzheimer’s research tainted by image fabrication, with far-reaching implications for the field? I take a deep look for @ScienceMagazine science.org/content/article/… 🧵 1/11

Potential fabrication in research images threatens key theory of Alzheimer’s disease

A neuroscience sleuth challenges data showing one toxic form of amyloid protein is a cause of brain condition

science.org
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New work from our lab shows how pericyte loss during brain aging contributes to blood flow disruption and capillary rarefaction. A repair strategy to mitigate these effects exists (pericyte remodeling), but needs help in the aged brain. biorxiv.org/content/10.1101/…
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Considering the extent of pericyte loss seen in Alzheimer's disease and related dementias, we need to find ways to protect these cells early in disease progression.
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One of the last papers from my PhD is published today. Really proud of this one😎 nature.com/articles/s43587-0… Thanks to: @TharickAPascoal @firoza_lussier @CecileTss @BezginGleb @StijnServaes @andrealessa @NicholasAshton @TommyKakari @KunachP @yitingtinawang @pedrorosaneto

Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

Nature Aging - The authors used PET imaging to stage individuals according to the Braak neuropathological system for Alzheimer’s disease. PET stage was associated with biomarker and cognitive...

nature.com
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what level of procrastination is taking all of the skill quizzes on linked in???
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my mental health is not loving the constant oscillation between “this is such a great idea - i’m a genius” and “this is complete garbage and will never work” while writing a research proposal lol
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new episode just dropped! here's the latest on how #vascular health feeds into #Alzheimer disease: amindr.com/episodes/274-vasc… #BBB #pericyte #CAA

AMiNDR: A Month in Neurodegenerative Disease Research

Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their...

amindr.com
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🚨🚨🚨 I am thrilled to announce my recent first author paper from @LasagnaLab is out now in @CommsBio describing a distinct profile of astrocytes activated by endothelial cells and associated with CAA! Thank you @alzassociation @NIH for the support. nature.com/articles/s42003-0…

Activated endothelial cells induce a distinct type of astrocytic reactivity

Communications Biology - Injured endothelial cells are shown to induce an A1 phenotype in astrocytes, characterized by a genetic signature associated with extracellular matrix remodeling factors...

nature.com
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first episode on #vascular contributions to #AD covering papers from 2022 is out! was thrilled to see some familiar names among the authors this month @OBracko @bethsbrainbites 🥳 amindr.com/episodes/271-vasc… #BBB #pericytes @AMiNDR_podcast

AMiNDR: A Month in Neurodegenerative Disease Research

With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this...

amindr.com
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When I started my PhD, every other student in the lab was frustrated and burnt out, and I naively believed that my time would be different, that these were individual problems and I would somehow be a 'better,' more successful student. Oh how wrong I was...
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What a great way to start the day, with a meeting with our sorting team!! We sort 600+ abstracts every month into categories within the field of #alzheimer's research. These categories make our episodes, accessible wherever you listen to #podcasts! #scicomm
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new @AMiNDR_podcast episode on vascular contributions to Alzheimer disease just dropped! check it out here for your monthly overview of the literature: amindr.com/episodes/263-vasc…

AMiNDR: A Month in Neurodegenerative Disease Research

Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on...

amindr.com
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This table has to be the most damning and depressing reflection of both the amyloid hypothesis and the current front-runners for Alzheimer’s disease modification that I can think of. By any objective mood measurement scale, my rating drops by 30% when I look at this.
Alberto J Espay@AlbertoEspay10 Feb 2022
Replying to @barttels2 @ProfRobHoward @pash22 @SharonLeeMoon @LonSchneiderMD @biogen @BosBizRowan @geoperry @MadhavThambiset @MariaGlymour @reshmagar @SamGandy @Philalz @drgdanielgeorge @CMSGov @ZacharyBrennan @EWidera @SECGov @FTC @GreenwallFdn @akesselheim @alzassociation @PharmaceuticBen @Ipsitv @ABC @MedicareGov @NicholasFlorko @Alzheon @AmberTongPW @GOP @jsross119
The anti-amyloid pipeline has been vibrant for 2 decades. Amyloid lowering was achieved in ~75% of 40 trials. Yet in ~40%, outcomes favored placebo over treatment. We have been unable to falsify the amyloid hypothesis because of hope, belief, and, yes, greed.
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My journey thus far… High school: What is Alzheimer’s? Undergrad: What is there than we can do to help find the cure for Alzheimer’s? PhD 2020: What is there we can do to find Alzheimer’s? PhD 2021: What is Alzheimer’s? PhD 2022: What?
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It is out in the @officialEANM journal! What's the biological interpretation of FDG-PET brain hypometabolism? In this work led by @andreia_rocha_ we mimicked dementia-like cortical FDG hypometabolism by only reducing glutamate transport in astrocytes.bit.ly/3rrfrW2 1/+
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A large multinational meta-analysis says that a third of cognitively normal people over 70 walk around with amyloid plaques in their brains. ow.ly/lMey50HNaye
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PhD students tend to choose a lab based on the topic, but a creative and supportive environment is more important. If everyone in the lab is miserable, you will probably be miserable there too; and if they are happy and thriving, you'll also likely feel good about yourself there.
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