Entrepreneur, investor, biohacker and Techie, Jazz pianist, campaigner against injustice.
Birmingham
Joined January 2010
- Tweets11.1K
- Following1.2K
- Followers10.8K
- Likes186
I wonder sometimes about @monzo they do things that are really odd and give no explanation.
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researchsquare.com/article/r… Which genes' splicing changes with age? A genome-wide analysis of 2.8 million junction tests in GTEx v8
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preprints.org/manuscript/202…
Different tissues in the body age in different ways.
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Regional and person-associated variation in age-related intronic RNA across human tissues doi.org/10.5281/zenodo.23947…
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John Hemming retweeted
"The longevity industry exists to exploit humanity, not to save it." - Seamus O'Mahony writes @TheLancet
Or, as he puts it, "the longevity industry is a goldrush without gold."
Talk about throwing out the baby with the bathwater!
Of course, the field is drowning in hype and commercial interests pushing unproven interventions. But that doesn't detract from the fact that slowing human aging - even if slightly - would have enormous health and medical benefits.
Manipulating human aging may prove harder than many in the field currently promise. But aging is no doubt malleable, so let's not lose sight of the field's long-term transformative potential.
The challenge is to tell hype from science, not to dismiss the science because of the hype.
Longevity is a political concern
thelancet.com/journals/lance…
John Hemming retweeted
9 in 10 drugs fail in trials. Most fail because the target was wrong.
At Gero we built and now open sourced a tool to score any target list against the only ground truth there is: clinical trial outcomes. Paper out in Bioinformatics (see the refs below, the code is open).
A few things we found:
– The famous “genetic support = 2.6x more likely to reach approval” reproduces, with open data, no Citeline needed.
– More clinical data makes the benchmark worse. Pool every open registry and 2.6x collapses to 1.5x. Curated beats aggregated.
We use this on our own models. Use it on yours. pip install ct-validation
More info on my substack peterfedichev.substack.com/p….
– this is a bit more reliable way to get updates like this.
As usual, please follow, like and repost - more interesting stuff to come.
Amedea Pharma Presents 2026 Medical Innovation Olympics Winners -- Finalists Earn San Francisco Presentations Duri... prn.to/4yXIMaF
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Protracted Fate Acquisition and Epigenetic De‐Aging During Induced Neural Stem Cell Conversion of Human Blood Cells - Berg - 2026 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/… "we found that this process is largely protracted, continuing for several weeks"
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Alternative Isoforms as Molecular Modulators of Cellular Senescence in Cancer mdpi.com/4131400 #mdpicancers via @Cancers_MDPI - An interesting look at the relationship between splicing, senescence and cancer.
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This is an interesting paper which is further evidence for ageing and development being in part linked to splicing isoform fate decisions. (including NMD)
Our paper is out in @NatureAging. We looked for factors that make old cells' gene expression young without erasing their identity. SRSF1 came out as a promising rejuvenation target that reduced aging hallmarks in human cells and extended median lifespan of aged mice by 14%.
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ALT Watercolor-style graphic of two overlapping cells split by a curved diagonal. On the left, a muted gray cell with a dark nucleus and faint white circuit traces. On the right, the same form in luminous blue, its circuitry lit up. Short dashes standing for RNA transcripts scatter loosely in gray on the left and fan outward in blue and pale green arcs on the right. Art by Helen H. Wang.
John Hemming retweeted
Our paper is out in @NatureAging. We looked for factors that make old cells' gene expression young without erasing their identity. SRSF1 came out as a promising rejuvenation target that reduced aging hallmarks in human cells and extended median lifespan of aged mice by 14%.
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ALT Watercolor-style graphic of two overlapping cells split by a curved diagonal. On the left, a muted gray cell with a dark nucleus and faint white circuit traces. On the right, the same form in luminous blue, its circuitry lit up. Short dashes standing for RNA transcripts scatter loosely in gray on the left and fan outward in blue and pale green arcs on the right. Art by Helen H. Wang.
The Book "Protocols", by Andrew @hubermanlab is a good investment of reading time. Not a job to be delegated to an LLM. It is also a good price. (at the moment).
John Hemming retweeted
🎉 The BSRA has a new Chair!
Bradley Elliott (@Brads_science) has been appointed to lead the Society. Former chair @dweinkove will remain as a Trustee focusing on policy and partnerships.
Congratulations Bradley, and thank you David! 👏
bsra.org.uk/bradley-elliott-…
John Hemming retweeted
Cailin McGurk (Morgan Stanley) moderating "Therapeutic Assets & Licensing (Late Stage)" at #ARDD2026 -- Mark Cobbold (AstraZeneca) and Phil McGurk (Takeda) on dealmaking for longevity assets. The BD infrastructure is finally catching up to the science. agingpharma.org/program2026
John Hemming retweeted
Insilico has nominated ISM1354, an AI-designed GIPR antagonist, as a preclinical candidate for obesity. Reported animal data include 75-104% oral bioavailability and 18x plasma exposure vs a benchmark. Human efficacy remains untested. drugtargetreview.com/news/in…
