J Brew retweeted
human eggs can release a burst of zinc when they are activated.
researchers call it a “zinc spark.” here’s how they see it:
zinc leaves the egg and binds a fluorescent probe. under the microscope’s illumination, the probe produces the bright signal.
the flash makes a chemical release visible.
in a 2016 study, researchers activated human eggs experimentally and tracked zinc release alongside changes in calcium inside the egg.
this is what i love about measurement: a hidden chemical event becomes something you can follow through time.
J Brew retweeted
More capable models will introduce increased biological risk. The magnitude is fiercely debated, the direction is not.
We need more resilient biodefense.
J Brew retweeted
This👇should have MILLIONS of retweets.
Dr. Jha was President Biden's Covid coordinator.
"Rand Paul is right — NIH helped fund risky work in Wuhan that spliced bat virus fragments together like a game of chance, under weak safety rules." —Dr. Jha
"Like a game of chance."
Read BIOLOGICAL WAR: A SCENARIO to understand how the next *game* could end.
@ashishkjha @RandPaul
This from my friend, Stanford's David Relman, on Covid origins is worth your time.
David helped write federal biosecurity policy and is one of the most thoughtful, even-handed experts in the country.
David says:
Rand Paul is right — NIH helped fund risky work in Wuhan that spliced bat virus fragments together like a game of chance, under weak safety rules.
Tony Fauci is right too — that published work doesn't look like a plausible Covid precursor.
Relman says what's needed now:
— Everyone claiming certainty should back off and show some humility
— A real, transparent, international investigation
— Scientists accept guardrails on risky research; political leaders commit to honest public debate
We're doing none of it.
J Brew retweeted
We are as gods, and we might as well get good at it.
-- @stewartbrand
ordinaryabundance.com
J Brew retweeted
Adding every reciprocal of a square number produces π²/6 exactly.
∑ₙ₌₁^∞ 1/n² = π²/6
Euler settled the Basel problem with this closed form in 1734.
J Brew retweeted
« À tout âge l'étude de la nature émousse le goût des amusements frivoles, prévient le tumulte des passions, et porte à l'âme une nourriture qui lui profite en la remplissant du plus digne objet de ses contemplations. »
Jean-Jacques Rousseau,Lettres élémentaires sur la botanique.
J Brew retweeted
What is Life? Well...
Final version is finally out:
"What Lives? A Meta-Analysis of Diverse Opinions on the Definition of Life"
@karina__kofman @blaiseaguera @reedbndr
link.springer.com/article/10…
For the first time, researchers have simulated nearly every chemical reaction in a living bacterial cell
go.nature.com/46UnkYp
J Brew retweeted
Neuroscience: Does the brain store knowledge in connection strengths? No it doesn't.
Geoffrey Hinton, the LLMs-have-subjective-experiences BSer strikes again. Dear Lord. 🙄
Always take everything coming from Hinton with a grain of salt. The man is a professional sci-fi fruitcake and propagandist working for the fake-AI mafia. He knows nothing about how the brain works. It is not true that the brain stores knowledge in connection strengths. This is what deep neural nets do, not the brain.
Short and long-term memory
In the brain, a connection is either made or not. The synaptic strength (if any) is a measure of how permanent the connection is. It's not a knowledge gradient. Unless rehearsed repeatedly, the connection is lost. Almost all that we learn on-the-fly is quickly forgotten. The brain remembers very little of what it experiences. It doesn't have to because it can use its sensors to learn anything on the fly in short-term memory.
This is why actors, musicians, dancers and athletes have to practice constantly. Eventually, our sensorimotor knowledge is transferred to the cerebellum where it becomes second nature.
Timing is critical
Knowledge in the brain has to do with timing, i.e., whether or not discrete sensory signals are concurrent or sequential. The brain uses timing signals generated by the hippocampus to time everything. Even the signals generated by the retina are precisely timed by the hippocampus. Indeed, the salience (strength) of a visual signal generated by a retinal ganglion cell is time-encoded. Retinal spikes travel via the optic nerve to the thalamus-LGN where they are decoded before being sent to the visual cortex.
Differentiation vs gradient learning
The brain uses a completely different method for pattern learning and recognition. It doesn't compress pattern data in connection weights a la deep learning. It discovers what differentiates one pattern from all others. That is, it learns what is unique about every pattern. There is a little was going on in the cortex. Awakened percepts in the cortical columns compete for possession of parts of the sensory space. Whatever survives from this battle is remembered. This clever differentiation method is orders of magnitude more efficient than deep learning.
The brain is primarily a massive timing mechanism. Nature knows best. I love the brain. 😍🧠
Geoffrey Hinton says AI hallucinations should actually be called confabulations
Neither human brains nor AI models store memories in a filing cabinet; both construct recall on the fly using connection strengths
Because of this, both will confidently generate plausible answers without knowing the ground truth
J Brew retweeted
What if we're all PARTIALLY right... about AI?
Skeptics, e/acc, safetyists, ethicists, china-hawks... the AI debate has become a hot mess. So I tried to act it out.
Watch the results below.
If I butchered your accent, I do not apologize. This was not an easy film to make.
J Brew retweeted
Wolfram's episode seems to be growing thanks to people sharing clips
it was a VERY strange take on worthy successor, but I'm glad it's getting people talking
there are many more big names coming up - its an exciting year for worthy successor dialogue
J Brew retweeted
Heinlein is heavily influenced by Korzybski and he's funny!! I highly suggest reading this book!!
J Brew retweeted
Replying to @elonmusk @aaronburnett
Exploration and understanding go hand in hand 🤝🚀🌌
J Brew retweeted
Absolutely, although the motor movement would be transduced from hydraulic power (Pascal's Law) flooding the femora, tibiae, tarsi with haemolymph (F=PA). Not the contracted myosin/actin filaments transduced by electrochemical resting/action membrane potentials and synapse calcium ion channels of majority other eukaryotes, nor the reverse electromagnetic induction of the electric current manipulating magnetic field in traditional motors.
J Brew retweeted
Replying to @CankayKoryak
I believe each consequence and it's opposite exist in all minds but that minds can strive for free will.
The line separating free will and determinism passes right through every mind, and through all minds. This line shifts. Inside us, it oscillates with the years.
Inspired by Aleksandr Solzhenitsyn
J Brew retweeted
A million seconds ago was October 11th
A billion seconds ago was 1993
A trillion seconds ago was 30,000 B.C.
The US national debt is now rising by $1 Trillion every ~180 days.
J Brew retweeted
Dr Oz is a brilliant mind. He speaks about fraud and systemic failures in healthcare that particularly affect people with terminal illnesses such as Alzheimer’s, cancer, ALS, and Parkinson’s. Hospice care is essential; however, once it becomes heavily commercialised, it risks turning into what are effectively long-term euthanasia centres.



































