@structureltp

Scientist. Personal account.

 Madrid, Spain
Joined September 2022
  • Tweets1.3K
  • Following154
  • Followers299
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🧬 How do bacteria open a molecular ring to start DNA replication? Excited to share our new work in NAR @OxUniPress, where we reveal how the ancestral helicase loader DciA opens the bacterial replicative helicase DnaB. @CIB_CSIC academic.oup.com/nar/article… 🧵👇
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Replying to @EAriasPalomo @OxUniPress @CIB_CSIC
Very cool, congratulations!
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Replying to @ChrisVMDHealth
Grifters will be grifters, PhD or not.
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Replying to @realDaveFeldman @DrMarthaGulati
Why did you publish an article without your primary endpoint? Or rather, change the primary endpoint in the paper from what was defined previoulsy?
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Lucas Tafur retweeted
Marcus Goncalves
@MarcusDGonOct 19
Glutamine + chemo in pancreatic cancer: Phase 1 GlutaPanc, n=16, 81% cachectic at baseline. 30g/day oral glutamine + full-dose gem/nab-paclitaxel, no glutamine DLTs. ORR 44%. nature.com/articles/s43018-0…

l-Glutamine in combination with first-line gemcitabine and nab-paclitaxel in advanced pancreatic...

Nature Cancer - In this open-label, single-arm, phase 1 GlutaPanc trial, Gong and colleagues report the safety and feasibility of l-glutamine in participants with advanced pancreatic ductal...

nature.com
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🚨 New paper from the Bustamante Lab in @NatureComms! Our study reveals how the central coupler of ClpXP helps coordinate its subunits to convert chemical energy into mechanical force Check it out! 👇 doi.org/10.1038/s41467-026-7…

The central coupler of ClpXP controls intersubunit communication and couples intrasubunit chemical...

Nature Communications - What is the mechanism by which ClpXP utilizes ATP to unfold proteins? Using single-molecule, biochemical and structural methods, the authors find that the central coupler...

nature.com
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Replying to @IsraelF96135088 @SternbergLab
Cool stuf, congrats!
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Today, our work in partnership once again with @SternbergLab presenting the structures of several DRT10 bacterial defense systems and comprehensive analysis of their mechanisms of action is published… very happy! Great work guys! nature.com/articles/s41586-0…

Antiviral immunity via telomerase-like reverse transcription in bacteria

Nature - Antiviral immunity via telomerase-like reverse transcription in bacteria

nature.com
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Replying to @Gonzalez_JT @HenryJMartyn @JamesyMorton
10 to 90 is a big jump. Why not test an intermediate dose? (Honest question!)
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Lucas Tafur retweeted
Efeyan Lab@EfeyanLabOct 5
Interested in cancer metabolism? We have a 4y FPI-funded PhD student position available in my lab to study the metabolic interplay of cancer cells and their microenvironment.
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Replying to @G__Napolitano @Nature
Congrats, Gennaro, very cool!!
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Happy to see our paper, led by outstanding postdoc Alessandra Esposito, out in @Nature today. We uncovered a TBK1/ULK1 signaling pathway that acts as a lysosome quality control mechanism, regulating the FLCN-TFEB axis in response to lysosomal stress Link: rdcu.be/icEViqq6F68a
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No es que no estén validados (que no lo están), es que su fundamento científico es entre endeble y nulo, más cerca de nulo, a día de hoy.
Rocio Gonzalez@rocioglezsolSep 29
👏🏻👏🏻 “No tiene ningún sentido hacerse test de microbiota, no están validados” @rosacampo agenciasinc.es/Entrevistas/N…

“No tiene ningún sentido hacerse test de microbiota, no están validados”

La investigadora desgrana las posibilidades terapéuticas de las comunidades microbianas que habitan nuestro organismo o por qué todavía no podemos utilizarlas para personalizar la atención médica....

agenciasinc.es
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Why do muscle fibres shrink with age? Not because myofibrils get smaller — because there are fewer of them. We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse. Tweetorial below Open Access here: physoc.onlinelibrary.wiley.c…
The Hornberger Lab@HornbergerLabFeb 18
1/ Why do muscles atrophy with aging and disuse? Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils? In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/shor… Full breakdown of the findings in this thread 👇
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Replying to @KetoCarnivore @KETONOIRai
Do you have a primary citation for that claim? I.e. experimental evidence of any kind.
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Finally a more intuitive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_… (Character idea from @HannesStaerk & Alex Waldherr)
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Replying to @pdhsu
Why did you work out fasted?
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Replying to @Brady_H
Doesn’t look like Peruvian, just the Pollo a la brasa 🥴
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Replying to @ChrisMasterjohn
Point 2 sounds like seed oils
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Replying to @Brady_H
*Resting is the key word. What about the energy cost of moving and doing things with higher muscle mass? Resting EE is only informative if you’re in coma or immobilized.
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